Please use this identifier to cite or link to this item: http://repositorio.ufpa.br:8080/jspui/handle/2011/10874
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dc.creatorALMEIDA, Izabela Negrão Frota de-
dc.creatorALMEIDA, Luciana Negrão Frota de-
dc.creatorSOBRINHO, Edmundo Frota de Almeida-
dc.creatorGOMES, Bruno Duarte-
dc.creatorSOUZA, Givago da Silva-
dc.creatorROSA, Alexandre Antonio Marques-
dc.creatorSILVEIRA, Luiz Carlos Lima-
dc.date.accessioned2019-04-05T19:05:03Z-
dc.date.available2019-04-05T19:05:03Z-
dc.date.issued2015-06-02-
dc.identifier.citationALMEIDA, Izabela Negrão Frota de et al. Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age-related macular degeneration before, during, and after treatment with ranibizumab. Arquivos Brasileiros Oftalmologia, São Paulo, v. 78, n. 2, p. 105-109, abr 2015. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/10874. Acesso em:.pt_BR
dc.identifier.issn0004-2749pt_BR
dc.identifier.urihttp://repositorio.ufpa.br/jspui/handle/2011/10874-
dc.description.abstractTo evaluate retinal morphology and function of patients with advanced neovascular age-related macular degeneration (AMD) before, during, and after treatment with ranibizumab. Methods: Twenty-one eyes diagnosed with advanced AMD were studied with optical coherence tomography (OCT) and multifocal electroretinography (mfERG). Three intravitreal injections of ranibizumab were administered at 1-month intervals. Evaluations were performed before the first injection (D0) and at 30 (D30), 60 (D60), and 90 days (D90) after the first injection and compared to an age-matched control group (n=21 eyes). Results: The thickness of macular retinal layers increased before treatment due to the presence of intraretinal fluid. A thick retinal pigment epithelium-choriocapillaris complex (RPE-CC) suggested the presence of choroidal neovascular membrane. Intraretinal edema decreased after treatment (P<0.01), but persisting RPE-CC thickness resulted in a subretinal scar. Three different annular retinal areas were studied with mfERG (from center to periphery: rings R1, R2, and R3). The amplitude of the first negative component (N1) decreased in R1, R2, and R3 at D30, D60, and D90 when compared with that in controls (P<0.05); the N1 implicit time was delayed in R3 at D30 (P<0.05). The amplitude of the first positive component (P1) was reduced in R1 and R2 at D30, D60, and D90 when compared with that in controls (P<0.01); the P1 implicit time was delayed in R1 at D0 and D60 (P<0.05), in R2 at D0, D30, and D90 (P<0.01), and in R3 at D30 and D60 (P<0.05). Conclusion: Ranibizumab reduces intraretinal edema, even in advanced cases. Central macular activity appeared to increase after the initiation of treatment, improving over time.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal do Parápt_BR
dc.relation.ispartofArquivos Brasileiros de Oftalmologiapt_BR
dc.rightsAcesso Abertopt_BR
dc.source.urihttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492015000200010&lng=pt&nrm=isopt_BR
dc.subjectMacular degeneration/drug therapypt_BR
dc.subjectAntibodiespt_BR
dc.subjectTomography optical coherencept_BR
dc.subjectElectroretinographypt_BR
dc.subjectIntravitreal injectionspt_BR
dc.titleOptical coherence tomography and multifocal electroretinography of patients with advanced neovascular age related macular degeneration before, during, and after treatment with ranibizumabpt_BR
dc.title.alternativeTomografia de coerência óptica e eletrorretinografia multifocal de pacientes com degeneração macular relacionada à idade, neovascular avançada, antes, durante e após o tratamento com ranibizumabept_BR
dc.typeArtigo de Periódicopt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.initialsUFPApt_BR
dc.creator.Latteshttp://lattes.cnpq.br/1740867152012675pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/2667980094488362pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/4949910049652505pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/4932238030330851pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/5705421011644718pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/4972772795172243pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/9383834641490219pt_BR
dc.identifier.doihttp://dx.doi.org/10.5935/0004-2749.20150027pt_BR
dc.description.affiliationGOMES, Bruno Duarte. Universidade Federal do Pará, Instituto de Ciências Biológicas (ICB)pt_BR
Appears in Collections:Artigos Científicos - ICB

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