Please use this identifier to cite or link to this item: http://repositorio.ufpa.br:8080/jspui/handle/2011/2422
metadata.dc.type: Artigo de Periódico
Issue Date: Jun-2010
metadata.dc.creator: VIEIRA, José Luiz Fernandes
RIVERA, Juan Gonzalo Bardález
MARTINS, Ana de Nazaré Silva
SILVA, Jorge Pereira da
SALGADO, Claudio Guedes
Title: Methemoglobinemia and dapsone levels in patients with leprosy
Citation: VIEIRA, Jose Luiz Fernandes et al. Methemoglobinemia and dapsone levels in patients with leprosy. Brazilian Journal of Infectious Diseases, Salvador, v. 14, n. 3, p.319-321, maio/jun. 2010. Disponível em: <http://www.scielo.br/pdf/bjid/v14n3/v14n3a22.pdf>. Acesso em: 14 dez. 2011. http://dx.doi.org/10.1590/S1413-86702010000300022.
Abstract: The objective of this work was to determine the methemoglobinemia and correlate with dapsone levels in multibacillary leprosy patients under leprosy multi-drug therapy. Thirty patients with laboratory and clinical diagnosis of multibacillary leprosy were enrolled. Dapsone was analyzed by high performance liquid chromatography and methemoglobinemia by spectrophotometry. The mean dapsone concentrations in male was 1.42 g/mL and in female was 2.42 g/mL. The mean methemoglobin levels in male was 3.09 µg/mL; 191%, and in female was 2.84 ± 1.67%. No correlations were seen between dapsone levels and methemoglobin in male and female patients. Our results demonstrated that the dosage of dapsone in leprosy treatment does not promote a significant methemoglobinemia.
Keywords: Metemoglobina
Dapsona
Hanseníase
Doenças infecciosas
ISSN: 1413-8670
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - FARM/ICS

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