Please use this identifier to cite or link to this item: http://repositorio.ufpa.br/jspui/handle/2011/2518
metadata.dc.type: Artigo de Periódico
Issue Date: Oct-2010
metadata.dc.creator: SILVA, Edinete Melo da
ACOSTA, Angelina Xavier
SANTOS, Eduardo José Melo dos
MARTINS NETTO, Eduardo
LEMAIRE, Denise Carneiro
OLIVEIRA, Adriano Silva
BARBOSA, Ana Caroline de Matos
BENDICHO, Maria Teresita
CASTRO FILHO, Bernardo Galvão
ALVES, Carlos Roberto Brites
Title: HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil
Citation: SILVA, Edinete Melo da et al. HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil. Brazilian Journal of Infectious Diseases, Salvador, v. 14, n. 5, p. 468-475, out. 2010. Disponível em: <http://www.scielo.br/pdf/bjid/v14n5/v14n5a08.pdf>. Acesso em: 05 mar. 2012. <http://dx.doi.org/10.1590/S1413-86702010000500008>.
Abstract: Host genetic factors play an important role in mediating resistance to HIV-1 infection and may modify the course of infection. HLA-B alleles (Bw4 epitope; B*27 and B*57) as well as killer cell immunoglobulin-like receptors have been associated with slow progression of HIV-1 infection. OBJECTIVE: To evaluate the association between serological epitopes HLA-Bw4 and HLA-Bw6 and prognostic markers in AIDS. METHODS: 147 HIV-infected individuals in Bahia, Northeast Brazil, were genotyped for HLA class I locus. HLA class I genotyping was performed by hybridization with sequence-specific oligonucleotide probes following amplification of the corresponding HLA-A, HLA-B and HLA-C genes. Statistical analysis was performed using Fisher's exact and ANOVA tests for categorical and continuous variables, respectively. RESULTS: We detected a significant association (χ2 = 4.856; p = 0.018) between the presence of HLA-Bw4 and low levels of viremia. Eighteen out of the 147 HIV-infected individuals presented viremia <1,800 copies/mL and 129 presented viremia > 2,000 copies/mL. Ninety and four percent (17/18) of all individuals with viremia < 1,800 copies/mL carried HLA-Bw4, compared to 67.4% (87/129) of individuals with viremia > 2,000 copies/mL. Additionally, we found a significantly higher frequency of B*57 (OR = 13.94; 95% CI = 4.19-46.38; p < 0.0001) and Cw*18 (OR = 16.15; 95% CI = 3.46-75.43; p < 0.0001) alleles, favoring the group with lower viremia levels, in comparison with those with higher viral load. CONCLUSION: HLA-Bw4-B*57 and Cw*18 alleles are associated with lower level of viral load in HIV-infected Brazilian patients. These findings may help us in understanding the determinants of HIV evolution in Brazilian patients, as well as in providing important information on immune response correlates of protection for such population.
Keywords: Polimorfismo genético
HIV-1
Genética de populações
Salvador - BA
Bahia - Estado
Síndrome de Imunodeficiência Adquirida
ISSN: 1413-8670
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

Files in This Item:
File Description SizeFormat 
Artigo_HLABw4B.pdf1,1 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons