Please use this identifier to cite or link to this item: http://repositorio.ufpa.br/jspui/handle/2011/3430
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Type: Artigo de Periódico
Issue Date: Aug-2001
Authors: RODRÍGUEZ BURBANO, Rommel Mario
LIMA, Eleonidas Moura
KHAYAT, André Salim
BARBIERI Neto, J.
CABRAL, Isabel Rosa
BASTOS JR., L.
BAHIA, Marcelo de Oliveira
CASARTELLI, Cacilda
Title: Cytogenetic description of breast fibroadenomas: alterations related solely to proliferation?
Citation: BURBANO, R. R. et al. Cytogenetic description of breast fibroadenomas: alterations related solely to proliferation?. Brazilian Journal of Medical and Biological Research. Ribeirão Preto, v. 34, n. 8, p. 1003-1006, ago. 2001. Disponível em <http://www.scielo.br/pdf/bjmbr/v34n8/4143.pdf>. Acesso em: 31 jan. 2013. <http://dx.doi.org/10.1590/S0100-879X2001000800005>.
Abstract: Twelve breast fibroadenomas were analyzed cytogenetically and only four were found to have clonal alterations. The presence of chromosomal alterations in fibroadenomas must be the consequence of the proliferating process and must not be related to the etiology of this type of lesion. In contrast, the few fibroadenomas that exhibit chromosomal alterations are likely to be those presenting a risk of neoplastic transformation. Clonal numerical alterations involved chromosomes 8, 18, 19, and 21. Of the chromosomal alterations found in the present study, only monosomy of chromosomes 19 and 21 has been reported in breast fibroadenomas. The loss of chromosome 21 was the most frequent alteration found in our sample. The study of benign proliferations and their comparison with chromosome alterations in their malignant counterparts ought to result in a better understanding of the genes acting on cell proliferation alone, and of the genes that cause these cells to exhibit varied behaviors such as recurrences, spontaneous regression and fast growth.
Keywords: Neoplasias da mama
Fibroadenoma
Alterações cromossômicas
ISSN: 0100-879X
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

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