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dc.creatorLAURENTINO, Rogério Valois-
dc.creatorLOPES, Ivina Giselle Lima-
dc.creatorAZEVEDO, Vânia Nakauth-
dc.creatorMACHADO, Luiz Fernando Almeida-
dc.creatorMOREIRA, Márcio Ronaldo Chagas-
dc.creatorSOUZA, Lia Lobato Batista de-
dc.creatorISHAK, Marluísa de Oliveira Guimarães-
dc.creatorISHAK, Ricardo-
dc.creatorVALLINOTO, Antonio Carlos Rosário-
dc.identifier.citationLAURENTINO, R. V., et al. Molecular characterization of human T-cell lymphotropic virus coinfecting human immunodeficiency virus 1 infected patients in the Amazon region of Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 4, p. 371-376, jul. 2005. Disponível em: <>. Acesso em: 03 abr. 2013. <>.pt_BR
dc.description.abstractThe present work evaluated the epidemiology of human immunodeficiency virus 1/human T-cell lymphotropic virus (HIV-1/HTLV) coinfection in patients living in Belém (state of Pará) and Macapá (state of Amapá), two cities located in the Amazon region of Brazil. A total of 169 blood samples were collected. The sera were tested by enzyme-linked immunosorbent assay to determine the presence of antibodies anti-HTLV-1/2. Confirmation of infection and discrimination of HTLV types and subtypes was performed using a nested polymerase chain reaction targeting the pX and 5' LTR regions, followed by restriction fragment length polymorphism and sequencing analysis. The presence of anti-HTLV1/2 was detected in six patients from Belém. The amplification of the pX region followed by RFLP analysis, demonstrated the presence of HTLV-1 and HTLV-2 infections among two and four patients, respectively. Sequencing HTLV-1 5' LTR indicated that the virus is a member of the Cosmopolitan Group, Transcontinental subgroup. HTLV-2 strains isolated revealed a molecular profile of subtype HTLV-2c. These results are a reflex of the epidemiological features of HIV-1/HTLV-1/2 coinfection in the North region of Brazil, which is distinct from other Brazilian regions, as reported by previous studies.pt_BR
dc.rightsAcesso Aberto-
dc.subjectVírus linfotrópico de células T humanas tipo 1pt_BR
dc.subjectDiagnóstico laboratorialpt_BR
dc.subjectEpidemiologia molecularpt_BR
dc.subjectVírus 2 linfotrópico T humanopt_BR
dc.subjectBelém - PApt_BR
dc.subjectMacapá - APpt_BR
dc.subjectPará - Estadopt_BR
dc.subjectAmapá - Estadopt_BR
dc.subjectAmazônia brasileirapt_BR
dc.titleMolecular characterization of human T-cell lymphotropic virus coinfecting human immunodeficiency virus 1 infected patients in the Amazon region of Brazilpt_BR
dc.typeArtigo de Periódico-
Appears in Collections:Artigos Científicos - ICB

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