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metadata.dc.type: Artigo de Periódico
Issue Date: 2009
metadata.dc.creator: VISANI, Valeria
BARROS, Sara Regina Ribeiro Carneiro de
DANTAS FILHO, Heronides Adonias
ALMEIDA, Luciano Farias
LIMA, Ricardo Alexandre Cavalcanti de
FRAGOSO, Wallace Duarte
SALDANHA, Teresa Cristina Bezerra
ARAÚJO, Mário César Ugulino de
Title: Flow-batch analyser for preparation of calibration standard mixtures in simultaneous multicomponent spectrometric analysis
Citation: VISANI, Valeria, et al. Flow-batch analyser for preparation of calibration standard mixtures in simultaneous multicomponent spectrometric analysis. Eclética Química, São Paulo, v. 34, n. 2, p. 37-47, 2009. Disponível em: <>. Acesso em: 18 jul. 2013. <>.
Abstract: The application of multivariate calibration techniques to multicomponent analysis by UV-VIS molecular absorption spectrometry is a powerful tool for simultaneous determination of several chemical species. However, when this methodology is accomplished manually, it is slow and laborious, consumes high amounts of reagents and samples, is susceptible to contaminations and presents a high operational cost. To overcome these drawbacks, a flow-batch analyser is proposed in this work. This analyser was developed for automatic preparation of standard calibration and test (or validation) mixtures. It was applied to the simultaneous determination of Cu2+, Mn2+ and Zn2+ in polyvitaminic and polymineral pharmaceutical formulations, using 4-(2-piridilazo) resorcinol as reagent and a UV-VIS spectrophotometer with a photodiode array detector. The results obtained with the proposed system are in good agreement with those obtained by flame atomic absorption spectrometry, which was employed as reference method. With the proposed analyser, the preparation of calibration and test mixtures can be accomplished about four hours, while the manual procedure requires at least two days. Moreover, it consumes smaller amounts of reagents and samples than the manual procedure. After the preparation of calibration and test mixtures, 60 samples-1 can be carried out with the proposed flow-batch analyser.
Keywords: Analisador de fluxo de lotes
Espectroscopia de ultravioleta e visível
Análise multicomponente simultânea
Análise farmacêutica
ISSN: 1678-4618
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - FAQUI/ICEN

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