Please use this identifier to cite or link to this item: http://repositorio.ufpa.br/jspui/handle/2011/5695
Compartilhar:
Type: Artigo de Periódico
Issue Date: Jun-2007
Authors: BARBEDO, Mayara de Brito
RICCI, Ricardo
JIMENEZ, Maria Carolina Sarti
CUNHA, Maristela Gomes da
YAZDANI, Syed S
CHITNIS, Chetan E
RODRIGUES, Mauricio Martins
SOARES, Irene da Silva
Title: Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax
Citation: BARBEDO, Mayara B et al. Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 335-340, jun. 2007. Disponível em: <http://www.scielo.br/pdf/mioc/v102n3/5787.pdf>. Acesso em: 16 jun. 2014. <http://dx.doi.org/10.1590/S0074-02762007005000040>.
Abstract: In previous immuno-epidemiological studies of the naturally acquired antibody responses to merozoite surface protein-1 (MSP-1) of Plasmodium vivax, we had evidence that the responses to distinct erythrocytic stage antigens could be differentially regulated. The present study was designed to compare the antibody response to three asexual erythrocytic stage antigens vaccine candidates of P. vivax. Recombinant proteins representing the 19 kDa C-terminal region of MSP-1(PvMSP19), apical membrane antigen n-1 ectodomain (PvAMA-1), and the region II of duffy binding protein (PvDBP-RII) were compared in their ability to bind to IgG antibodies of serum samples collected from 220 individuals from the state of Pará, in the North of Brazil. During patent infection with P. vivax, the frequency of individuals with IgG antibodies to PvMSP119, PvAMA-1, and PvDBP-RII were 95, 72.7, and 44.5% respectively. Although the frequency of responders to PvDBP-RII was lower, this frequency increased in individuals following multiple malarial infections. Individually, the specific antibody levels did not decline significantly nine months after treatment, except to PvMSP119. Our results further confirm a complex regulation of the immune response to distinct blood stage antigens. The reason for that is presently unknown but it may contribute to the high risk of re-infection in individuals living in the endemic areas.
Keywords: Malária
Plasmodium vivax
Anticorpos
Imunologia
Imunoglobina G (IgG)
Proteínas
Antígeno
Anticorpos tipo IgG
ISSN: 0074-0276
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

Files in This Item:
File Description SizeFormat 
Artigo_ComparativeRecognitionHuman.pdf73,86 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons