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dc.creatorMARTINS, Luisa Caricio-
dc.creatorCORVELO, Tereza Cristina de Oliveira-
dc.creatorDEMACHKI, Samia-
dc.creatorARAÚJO, Marialva Tereza Ferreira de-
dc.creatorASSUMPÇÃO, Mônica Baraúna de-
dc.creatorVILAR, Simone Cristina Araujo Jucá-
dc.creatorFREITAS, Felipe Bonfim-
dc.creatorBARBOSA, Hivana Patricia Melo-
dc.creatorFECURY, Amanda Alves-
dc.creatorAMARAL, Renata Kelly Costa do-
dc.creatorSANTOS, Sidney Emanuel Batista dos-
dc.identifier.citationMARTINS, Luisa Caricio et al. Clinical and pathological importance of vacA allele heterogeneity and cagA status in peptic ulcer disease in patients from North Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 8, p. 875-881, dez. 2005. Disponível em: <>. Acesso em: 25 nov. 2014. <>.pt_BR
dc.description.abstractWe have examined the prevalence of gene cagA and vacA alleles in 129 patients, 69 with gastritis and 60 with peptic ulcer diseases from North Brazil and their relation with histopathological data. vacA and cagA genotype were determined by polymerase chain reaction. Hematoxylin-eosin staining was used for histological diagnosis. 96.6% of the patients were colonized by Helicobacter pylori strains harboring single vacA genotype (nont-mixed infection). Among them, 11.8% had subtype s1a, 67.8% had subtype s1b, and 17% subtype s2. In regard to the middle region analysis, m1 alleles were found in 75.4% and m2 in 21.2% of patients. The cagA gene was detected in 78% patients infected with H. pylori and was associated with the s1-m1 vacA genotype. The H. pylori strains, vacA s1b m1/cagA-positive, were associated with increased risk of peptic ulcer disease and higher amounts of lymphocytic and neutrophilic infiltrates and the presence of intestinal metaplasia. These findings show that cagA and vacA genotyping may have clinical relevance in Brazil.pt_BR
dc.rightsAcesso Aberto-
dc.subjectHelicobacter pyloript_BR
dc.subjectÚlcera pépticapt_BR
dc.subjectAlelos vacApt_BR
dc.subjectEstatos cagApt_BR
dc.subjectBrasil - Paíspt_BR
dc.titleClinical and pathological importance of vacA allele heterogeneity and cagA status in peptic ulcer disease in patients from North Brazilpt_BR
dc.typeArtigo de Periódicopt_BR
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