Please use this identifier to cite or link to this item: http://repositorio.ufpa.br:8080/jspui/handle/2011/6130
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dc.creatorFRANCEZ, Pablo Abdon da Costa-
dc.creatorCORVELO, Tereza Cristina de Oliveira-
dc.creatorSILVA, Flávio Ricardo Leal da-
dc.creatorSANTOS, Sidney Emanuel Batista dos-
dc.date.accessioned2014-12-01T12:51:50Z-
dc.date.available2014-12-01T12:51:50Z-
dc.date.issued2007-03-
dc.identifier.citationFRANCEZ, Pablo Abdon da Costa et al. Molecular analysis of three FUT3 gene single nucleotide polymorphisms and their relationship with the lewis erythrocytary phenotype in a human population of japanese-ancestry living in Tomé Açu, a town in the Brazilian Amazon. Genetics and Molecular Biology, São Paulo, v. 30, n. 2, p. 308-313, mar. 2007. Disponível em: <http://www.scielo.br/pdf/gmb/v30n2/a02v30n2.pdf>. Acesso em: 27 nov. 2014. <http://dx.doi.org/10.1590/S1415-47572007000300002>.pt_BR
dc.identifier.urihttp://repositorio.ufpa.br/jspui/handle/2011/6130-
dc.description.abstractThe Lewis blood group system involves two major antigens, Leª and Leb. Their antigenic determinants are not primary gene products but are synthesized by the transfer of sugar subunits to a precursory chain by a specific enzyme which is the product of the FUT3 gene (Lewis gene). The presence of three FUT3 gene single nucleotide polymorphisms (SNPs) (59T > G; 508G > A and 1067T > A) was related to the Lewis phenotype of erythrocytes from 185 individuals of Japanese ancestry living in the town of Tomé-Açu in the Brazilian Amazon region. This relationship was detected using a serological hemagglutination test and the Dot-ELISA assay along with the molecular technique PCR-RFLP. We found that the three SNPs investigated in this study only accounted for a proportion of the Lewis-negative phenotype of the erythrocytes.pt_BR
dc.language.isoengpt_BR
dc.rightsAcesso Aberto-
dc.subjectSistema do grupo sanguíneo de Lewispt_BR
dc.subjectReação em cadeia da polimerasept_BR
dc.subjectGene FUT3pt_BR
dc.subjectJaponesespt_BR
dc.subjectPolimorfismo genéticopt_BR
dc.subjectTomé-Açu - PApt_BR
dc.subjectPará - Estadopt_BR
dc.subjectAmazônia brasileirapt_BR
dc.titleMolecular analysis of three FUT3 gene single nucleotide polymorphisms and their relationship with the lewis erythrocytary phenotype in a human population of japanese-ancestry living in Tomé Açu, a town in the Brazilian Amazonpt_BR
dc.typeArtigo de Periódicopt_BR
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