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dc.creatorTEIXEIRA, Renan Kleber Costa-
dc.creatorYAMAKI, Vitor Nagai-
dc.creatorYASOJIMA, Edson Yuzur-
dc.creatorBRITO, Marcus Vinicius Henriques-
dc.identifier.citationTEIXEIRA, Renan Kleber Costa et al. Effect of copaiba oil in hepatic damage induced by acetaminophen in rats. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 7, p. 526-530, July 2013. DOI: Disponível em: Acesso em:.pt_BR
dc.description.abstractPURPOSE: To investigate the effects of copaiba oil on the hepatic damage induced by paracetamol. METHODS: Thirty six rats were distributed into six study groups (N=6): control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copaiba Group 1, that received copaiba oil two hours before the acetaminophen; Prophylactic Copaiba Group 7, that received copaiba oil seven days, once by day, before the acetaminophen; Therapy Copaiba Group, that received the copaiba oil two hours afther the acetaminophen; and N-Acetyl-Cysteine Group, , that received the N-Acetyl-Cysteine two hours afther the acetaminophen. Euthanasia was performed after 24 hours. The serum levels of AST, ALT, alkaline phosphatase, GT, total bilirubin, direct bilirubin and indirect bilirubin and histological analisis were analized. RESULTS: The prophylactic copaiba group 7, therapy copaiba group and N-Acetyl-Cysteine Group showed amounts of AST and ALT similar to the control group; and the prophylactic copaiba group 1 showed similar levels to the acetaminophen group. There was no significant difference between the groups regarding the amount of alkaline phosphatase and GT (p>0.05). The therapy copaiba group showed the highest levels of bilirubin and was statistically different from the other groups (p<0.01) and this increased the costs of direct bilirubin. Regarding histopathology, the oil of copaiba administered prophylactic or therapeutic form for 7 days could decrease the amount of necrosis and inflammatory infiltrate. CONCLUSION: Copaiba oil administered prophylactically for seven days, and therapeutic could reduce liver damage caused by paracetamol similarly N-Acetyl-Cysteine, however, when treated with copaiba therapeutically showed increases in bilirubin, costs increasing fraction indirect.en
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia-
dc.relation.ispartofActa Cirúrgica Brasileira-
dc.rightsAcesso Abertopt_BR
dc.subjectPlanta oleaginosapt_BR
dc.subjectÓleo de copaíbapt_BR
dc.subjectDoença hepática crônica induzida por drogapt_BR
dc.subjectRato como animal de laboratóriopt_BR
dc.titleEffect of copaiba oil in hepatic damage induced by acetaminophen in ratspt_BR
dc.typeArtigo de Periódicopt_BR
dc.description.affiliationYASOJIMA, E. Y. Universidade Federal do Pará-
Appears in Collections:Artigos Científicos - FAMED/ICS

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