Please use this identifier to cite or link to this item: http://repositorio.ufpa.br/jspui/handle/2011/6876
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Type: Artigo de Periódico
Issue Date: 2009
Authors: LIMA, Magaly do Bom Parto Lopes Vieira
OLIVEIRA FILHO, Aldemir Branco de
CAMPOS, Júlia Furtado
MELO, Fárida Coeli de Barros Correia
NEVES, Washington Batista das
MELO, Raul Antônio Morais
LEMOS, José Alexandre Rodrigues de
Title: Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population
Citation: LIMA, Magaly do Bom Parto Lopes Vieira et al. Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population. Genetics and Molecular Biology, São Paulo, v. 32, n. 2, p. 264-267, 2009. Disponível em: <http://www.scielo.br/pdf/gmb/v32n2/a10v32n2.pdf>. Acesso em: 8 set. 2015. <http://dx.doi.org/10.1590/S1415-47572009000200010>.
Abstract: Most cases of a predisposition to venous thrombosis are caused by resistance to activated protein C, associated in 95% of cases with the Factor V Leiden allele (FVL or R506Q). Several recent studies report a further increased risk of thrombosis by an association between the AB alleles of the ABO blood group and Factor V Leiden. The present study investigated this association with deep vein thrombosis (DVT) in individuals treated at the Hemocentro de Pernambuco in northeastern Brazil. A case-control comparison showed a significant risk of thrombosis in the presence of Factor V Leiden (OR = 10.1), which was approximately doubled when the AB alleles of the ABO blood group were present as well (OR = 22.3). These results confirm that the increased risk of deep vein thrombosis in the combined presence of AB alleles and Factor V Leiden is also applicable to the Brazilian population suggesting that ABO blood group typing should be routinely added to FVL in studies involving thrombosis.
Keywords: Trombose venosa
Fator V Leiden
Sistema do grupo sanguíneo ABO
Pernambuco - Estado
ISSN: 1678-4685
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

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