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metadata.dc.type: Artigo de Periódico
Issue Date: Dec-2008
metadata.dc.creator: SANTOS, Wallace Raimundo Araujo dos
MEYER, Wieland
COSTA, Solange do Perpétuo Socorro Evangelista
TRILLES, Luciana
NASCIMENTO, José Luiz Martins do
SOUSA, Rita Catarina Medeiros
MORALES, Bernardina Penarrieta
BEZERRA, Cláudia de Carvalho Falci
MACÊDO, Regina Célia Lima de
FERREIRA, Silvana O.
BARBOSA, Gláucia Gonçalves
PEREZ, Mauricio de Andrade
NISHIKAWA, Marília Martins
LAZÉRA, Márcia dos Santos
Title: Primary endemic Cryptococcosis gattii by molecular type VGII in the state of Pará, Brazil
Citation: SANTOS, Wallace Raimundo Araújo dos et al. Primary endemic Cryptococcosis gattii by molecular type VGII in the state of Pará, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 8, p. 813-818, dez. 2008. Disponível em: <>. Acesso em: 03 nov. 2011.
Abstract: In order to study the infectious agents causing human disseminated cryptococcosis in the state of Pará, North Brazil, 56 isolates of Cryptococcusspp. (54 isolated from cerebral spinal fluid and two from blood cultures) from 43 cases diagnosed between 2003-2007 were analysed. The species were determined through morphological and physiological tests and genotypes were determined by URA5-RFLP and PCR-fingerprinting (wild-type phage M13). The following species and genotypes were identified: Cryptococcus neoformans VNI (28/56, 50%), Cryptococcus gattii VGII (25/56, 44.64%) and C. gattii VGI (3/56, 5.26%). The genotype VNI occurred in 12 out of 14 HIV-positive adults, whereas the genotype VGII occurred in 11 out of 21 HIV-negative adults (p < 0.02, OR = 6.6 IC95% 0.98-56.0). All patients less than 12 years old were HIV negative and six cases were caused by the VGII genotype, one by the VGI and one by VNI. Therefore, endemic primary mycosis in HIV-negative individuals, including an unexpectedly high number of children, caused by the VGII genotype deserves further study and suggests the need for surveillance on cryptococcal infection in the state of Pará, Eastern Amazon.
Keywords: Cryptococcus gattii
Pará - Estado
Amazônia brasileira
Doenças endêmicas
ISSN: 0074-0276
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - FARM/ICS

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