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metadata.dc.type: Artigo de Periódico
Issue Date: Oct-2008
metadata.dc.creator: VIEIRA, José Luiz Fernandes
BORGES, Larissa Maria Guimarães
NASCIMENTO, Margareth Tavares Silva
GOMES, Andreza de Lourdes Souza
Title: Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil
Citation: VIEIRA, José Luiz Fernandes et al. Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil. Brazilian Journal of Infectious Diseases, Salvador, v. 12, n. 5, p. 353-354, out. 2008. Disponível em: <>. Acesso em: 16 dez. 2011.
Abstract: We examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline was used. We measured the quinine in the plasma samples on days 0 and 3by high performance liquid chromatography. The mean concentration of quinine was 6.04 ±2.21 µg/mL in male patients and 5.98 ±1.95 µg/mL in female patients. No significant differences in quinine concentration were observed between these two groups. All samples collected before starting treatment were negative for quinine. This information could help in the development of strategies for the rational use of antimalarial drugs in Brazil.
Keywords: Amazônia brasileira
Malária falciparum
ISSN: 1413-8670
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - FAMED/ICS

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