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dc.creatorSILVA, Edinete Melo da-
dc.creatorACOSTA, Angelina Xavier-
dc.creatorSANTOS, Eduardo José Melo dos-
dc.creatorMARTINS NETTO, Eduardo-
dc.creatorLEMAIRE, Denise Carneiro-
dc.creatorOLIVEIRA, Adriano Silva-
dc.creatorBARBOSA, Ana Caroline de Matos-
dc.creatorBENDICHO, Maria Teresita-
dc.creatorCASTRO FILHO, Bernardo Galvão-
dc.creatorALVES, Carlos Roberto Brites-
dc.identifier.citationSILVA, Edinete Melo da et al. HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil. Brazilian Journal of Infectious Diseases, Salvador, v. 14, n. 5, p. 468-475, out. 2010. Disponível em: <>. Acesso em: 05 mar. 2012. <>.pt_BR
dc.description.abstractHost genetic factors play an important role in mediating resistance to HIV-1 infection and may modify the course of infection. HLA-B alleles (Bw4 epitope; B*27 and B*57) as well as killer cell immunoglobulin-like receptors have been associated with slow progression of HIV-1 infection. OBJECTIVE: To evaluate the association between serological epitopes HLA-Bw4 and HLA-Bw6 and prognostic markers in AIDS. METHODS: 147 HIV-infected individuals in Bahia, Northeast Brazil, were genotyped for HLA class I locus. HLA class I genotyping was performed by hybridization with sequence-specific oligonucleotide probes following amplification of the corresponding HLA-A, HLA-B and HLA-C genes. Statistical analysis was performed using Fisher's exact and ANOVA tests for categorical and continuous variables, respectively. RESULTS: We detected a significant association (χ2 = 4.856; p = 0.018) between the presence of HLA-Bw4 and low levels of viremia. Eighteen out of the 147 HIV-infected individuals presented viremia <1,800 copies/mL and 129 presented viremia > 2,000 copies/mL. Ninety and four percent (17/18) of all individuals with viremia < 1,800 copies/mL carried HLA-Bw4, compared to 67.4% (87/129) of individuals with viremia > 2,000 copies/mL. Additionally, we found a significantly higher frequency of B*57 (OR = 13.94; 95% CI = 4.19-46.38; p < 0.0001) and Cw*18 (OR = 16.15; 95% CI = 3.46-75.43; p < 0.0001) alleles, favoring the group with lower viremia levels, in comparison with those with higher viral load. CONCLUSION: HLA-Bw4-B*57 and Cw*18 alleles are associated with lower level of viral load in HIV-infected Brazilian patients. These findings may help us in understanding the determinants of HIV evolution in Brazilian patients, as well as in providing important information on immune response correlates of protection for such population.pt_BR
dc.rightsAcesso Aberto-
dc.subjectPolimorfismo genéticopt_BR
dc.subjectGenética de populaçõespt_BR
dc.subjectSalvador - BApt_BR
dc.subjectBahia - Estado-
dc.subjectSíndrome de Imunodeficiência Adquirida-
dc.titleHLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazilpt_BR
dc.typeArtigo de Periódicopt_BR
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