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metadata.dc.type: Artigo de Periódico
Issue Date: Jun-2001
metadata.dc.creator: TRÉVIA, Nonata
ALMEIDA, Izabela Negrão Frota de
OLIVEIRA, Poliana Sampaio
WARWICK, Laura Vianna
MARQUES, Viviane
SANTOS, Denise Cristina dos
VIEGAS, Maria Luana Carvalho
DINIZ, Cristovam Wanderley Picanço
PAULO, Dario Carvalho
Title: Enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals
Citation: TREVIA, Nonata et al. Enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals. Psychology & Neuroscience, Rio de Janeiro, v. 4, n. 1, p. 49-56, jun. 2011. Disponível em: <>. Acesso em: 03 abr. 2012. <>.
Abstract: The aim of the present study was to analyze the influence of enriched environment on the distribution of perineuronal nets (PNNs) using a stereogically based unbiased protocol and visual acuity in adult Swiss albino mice that underwent monocular deprivation during the critical period of postnatal development. Eight female Swiss albino mice were monocular deprived were removed and cut at 70 µm thickness in a vibratome and processed for lectin histochemical staining with Wisteria floribunda agglutinin (WFA). Architectonic limits of area 17 were conspicuously defined by WFA histochemical staining, and the optical fractionator stereological method was applied to estimate the total number of PNNs in the supragranular, granular, and infragranular layers. All groups were compared using Student's t-test at a 95% confidence level. Comparative analysis of the average PNN estimations revealed that the EE group had higher PNNs in the supragranular layer (2726.33 ± 405.416, mean ± standard deviation) compared with the SE group (1543.535 ± 260.686; Student's t-test, p = .0495). No differences were found in the other layers. Visual acuity was significantly lower in the SE group (0.55 cycles/degree) than in the EE group (1.06 cycles/degree). Our results suggest that the integrity of the specialized extracellular matrix PNNs of the supragranular layer may be essential for normal visual acuity development.
Keywords: Acuidade visual
Córtex visual
Visão monocular
Período crítico (Psicologia)
ISSN: 1983-3288
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

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