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metadata.dc.type: Artigo de Periódico
Issue Date: Jul-2012
metadata.dc.creator: CARDOSO, Greice de Lemos
TAKANASHI, Silvania Yukiko Lins
GUERREIRO, João Farias
Title: Inherited hemoglobin disorders in an Afro-Amazonian community: Saracura
Citation: CARDOSO, Greice Lemos; TAKANASHI, Silvania Yukiko Lins; GUERREIRO, João Farias. Inherited hemoglobin disorders in an Afro-Amazonian community: Saracura. Genetics and Molecular Biology, São Paulo, v. 35, n. 3, p. 553-556, 2012, Epub 05 jul 2012. Disponível em: <>. Acesso em: 17 jul. 2013. <>.
Abstract: The most common hemoglobinopathies, viz, hemoglobins S and C, and α-and β-thalassemias, were investigated through the molecular screening of 116 subjects from the community of Saracura, comprising fugitive African slaves from farms of the municipality of Santarém, in the west of Pará State, Brazilian Amazon. The observed frequency of the HBB*S gene (0.9%) was significantly lower than that encountered in other Afro-derived communities in the region. Concomitantly, the absence of the HBB*C allele has been reported for most of the Afro-Amazonian communities thus far studied. As remnant populations of quilombos are generally small, the heterogeneous distribution of HBB*S and HBB*C alleles among them is probably due to genetic drift and/or founder effect. The observed frequency of 3.7 kb deletion in Saracura (8.5%) was consistent with the African origin of the population, with a certain degree of local differentiation and admixture with individuals of Caucasian ancestry, placed in evidence by the occurrence of - -(MED) deletion (1.2%), a common mutation in Mediterranean regions. As regards f-thalassemia, among the seven different mutations found in Saracura, three βºand two β+ mutations were of Mediterranean origin, and two β+ of African. Thus, only 28% of the local β-thalassemia mutations found in Saracura were of African origin.
Keywords: Anemia falciforme
Comunidade de Saracura - PA
Santarém - PA
Pará - Estado
Amazônia brasileira
ISSN: 1415-4757
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

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