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metadata.dc.type: Artigo de Periódico
Issue Date: 2004
metadata.dc.creator: BORGES, Barbara do Nascimento
HARADA, Maria Lúcia
Title: Divergent evolution and purifying selection of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini)
Citation: BORGES, Bárbara do Nascimento; HARADA, Maria Lúcia. Divergent evolution and purifying selection of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini). Genetics and Molecular Biology, São Paulo, v. 27, n. 3, p. 342-349, 2004. Disponível em: <>. Acesso em: 14 mar. 2014. <>.
Abstract: In the present study, the coding region of the H gene was sequenced and analyzed in fourteen genera of New World primates (Alouatta, Aotus, Ateles, Brachyteles, Cacajao, Callicebus, Callithrix, Cebus, Chiropotes, Lagothrix, Leontopithecus, Pithecia, Saguinus, and Saimiri), in order to investigate the evolution of the gene. The analyses revealed that this coding region contains 1,101 nucleotides, with the exception of Brachyteles, the callitrichines (Callithrix, Leontopithecus, and Saguinus) and one species of Callicebus (moloch), in which one codon was deleted. In the primates studied, the high GC content (63%), the nonrandom distribution of codons and the low evolution rate of the gene (0.513 substitutions/site/MA in the order Primates) suggest the action of a purifying type of selective pressure, confirmed by the Z-test. Our analyses did not identify mutations equivalent to those responsible for the H-deficient phenotypes found in humans, nor any other alteration that might explain the lack of expression of the gene in the erythrocytes of Neotropical monkeys. The phylogenetic trees obtained for the H gene and the distance matrix data suggest the occurrence of divergent evolution in the primates.
Keywords: Primata
Evolução molecular
Genética de populações
Gene H
ISSN: 1415-4757
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

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