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DC Field | Value | Language |
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dc.creator | FRANCEZ, Pablo Abdon da Costa | - |
dc.creator | CORVELO, Tereza Cristina de Oliveira | - |
dc.creator | SILVA, Flávio Ricardo Leal da | - |
dc.creator | SANTOS, Sidney Emanuel Batista dos | - |
dc.date.accessioned | 2014-12-01T12:51:50Z | - |
dc.date.available | 2014-12-01T12:51:50Z | - |
dc.date.issued | 2007-03 | - |
dc.identifier.citation | FRANCEZ, Pablo Abdon da Costa et al. Molecular analysis of three FUT3 gene single nucleotide polymorphisms and their relationship with the lewis erythrocytary phenotype in a human population of japanese-ancestry living in Tomé Açu, a town in the Brazilian Amazon. Genetics and Molecular Biology, São Paulo, v. 30, n. 2, p. 308-313, mar. 2007. Disponível em: <http://www.scielo.br/pdf/gmb/v30n2/a02v30n2.pdf>. Acesso em: 27 nov. 2014. <http://dx.doi.org/10.1590/S1415-47572007000300002>. | pt_BR |
dc.identifier.uri | http://repositorio.ufpa.br/jspui/handle/2011/6130 | - |
dc.description.abstract | The Lewis blood group system involves two major antigens, Leª and Leb. Their antigenic determinants are not primary gene products but are synthesized by the transfer of sugar subunits to a precursory chain by a specific enzyme which is the product of the FUT3 gene (Lewis gene). The presence of three FUT3 gene single nucleotide polymorphisms (SNPs) (59T > G; 508G > A and 1067T > A) was related to the Lewis phenotype of erythrocytes from 185 individuals of Japanese ancestry living in the town of Tomé-Açu in the Brazilian Amazon region. This relationship was detected using a serological hemagglutination test and the Dot-ELISA assay along with the molecular technique PCR-RFLP. We found that the three SNPs investigated in this study only accounted for a proportion of the Lewis-negative phenotype of the erythrocytes. | pt_BR |
dc.language.iso | eng | pt_BR |
dc.rights | Acesso Aberto | - |
dc.subject | Sistema do grupo sanguíneo de Lewis | pt_BR |
dc.subject | Reação em cadeia da polimerase | pt_BR |
dc.subject | Gene FUT3 | pt_BR |
dc.subject | Japoneses | pt_BR |
dc.subject | Polimorfismo genético | pt_BR |
dc.subject | Tomé-Açu - PA | pt_BR |
dc.subject | Pará - Estado | pt_BR |
dc.subject | Amazônia brasileira | pt_BR |
dc.title | Molecular analysis of three FUT3 gene single nucleotide polymorphisms and their relationship with the lewis erythrocytary phenotype in a human population of japanese-ancestry living in Tomé Açu, a town in the Brazilian Amazon | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
Appears in Collections: | Artigos Científicos - ICB |
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Artigo_MolecularAnalysThrees.pdf | 74,28 kB | Adobe PDF | View/Open |
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