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metadata.dc.type: Artigo de Periódico
Issue Date: Sep-2013
metadata.dc.creator: BRITO, Marcus Vinicius Henriques
ARAÚJO, Marialva Tereza Ferreira de
CUNHA, Luane Cristine Batista
OLIVEIRA, Antônio Jorge Barbosa de
RODRIGUES, Jacqueline Barreto
BRITO, Nathalya Botelho
metadata.dc.description.affiliation: ARAÚJO, M. T. F.; CUNHA, L. C. B. Universidade Federal do Pará
Title: Immediate graft histological assay, post pig's liver transplantation
metadata.dc.description.sponsorship: CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
Citation: BRITO, Marcus Vinicius Henriques et al. Immediate graft histological assay, post pig's liver transplantation. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 9, p. 678-682, Sept. 2013. DOI: Disponível em: Acesso em:.
Abstract: PURPOSE: To describe the vascular and tissue histopathological changes in seven sequential experimental liver transplantations in pigs. METHODS: Fourteen female pigs, Sus domesticus species, with body mass between 5 and 8 kg were utilized. After the end of all anastomoses of the graft implantation in the receptor, the animal was monitored for 30 minutes, and at its end one of the biopsies was collected for histological analysis. The histological criteria utilized were: lytic hepatocyte necrosis, density of septal and portal inflammatory infiltrated, sinusoidal congestion and hemorrhage. The analysis was performed separately for the portal region in zone 1, 2 and 3. RESULTS: Among the structural changes undergone by the graft, those with greater frequency and intensity were vascular congestion and steatosis, which stood out in transplantations 5, 6 and 7. CONCLUSIONS: The technique demonstrated vascular alterations represented by vasocongestion, edema and minimum inflammatory reaction. In relation to the parenchyma, was observed macrovacuolar pan-acinar steatosis, focal lytic and occasional hemorrhages, beyond the accumulation of hemosiderin in Kuppfer's cells.
Keywords: Histologia
Transplante de fígado
Liver transplantation
Series/Report no.: Acta Cirúrgica Brasileira
ISSN: 1678-2674 Brasil
Publisher: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
metadata.dc.publisher.initials: SOBRADPEC
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICS

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