Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.creatorBARRETO, Josafá Gonçalves-
dc.creatorGUIMARÃES, Layana de Souza-
dc.creatorFRADE, Marco Andrey Cipriani-
dc.creatorROSA, Patrícia Sammarco-
dc.creatorSALGADO, Claudio Guedes-
dc.identifier.citationBARRETO, Josafá Gonçalves et al. High rates of undiagnosed leprosy and subclinical infection amongst school children in the Amazon Region. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, supl. 1, p. 60-67, dez. 2012. Disponível em: <>. Acesso em: 16 nov. 2015. <>.pt_BR
dc.description.abstractLeprosy in children is correlated with community-level factors, including the recent presence of disease and active foci of transmission in the community. We performed clinical and serological examinations of 1,592 randomly selected school children (SC) in a cross-sectional study of eight hyperendemic municipalities in the Brazilian Amazon Region. Sixty-three (4%) SC, with a mean age of 13.3 years (standard deviation = 2.6), were diagnosed with leprosy and 777 (48.8%) were seropositive for anti-phenolic glycolipid-I (PGL-I). Additionally, we evaluated 256 house-hold contacts (HHCs) of the students diagnosed with leprosy; 24 (9.4%) HHC were also diagnosed with leprosy and 107 (41.8%) were seropositive. The seroprevalence of anti-PGL-I was significantly higher amongst girls, students from urban areas and students from public schools (p < 0.0001). Forty-five (71.4%) new cases detected amongst SC were classified as paucibacillary and 59 (93.6%) patients did not demonstrate any degree of physical disability at diagnosis. The results of this study suggest that there is a high rate of undiagnosed leprosy and subclinical infection amongst children in the Amazon Region. The advantages of school surveys in hyperendemic areas include identifying leprosy patients at an early stage when they show no physical disabilities, preventing the spread of the infection in the community and breaking the chain of transmission.pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectInfecção subclínicapt_BR
dc.subjectAmazônia brasileirapt_BR
dc.titleHigh rates of undiagnosed leprosy and subclinical infection amongst school children in the Amazon Regionpt_BR
dc.typeArtigo de Periódicopt_BR
Appears in Collections:Artigos Científicos - ICB

Files in This Item:
File Description SizeFormat 
Artigo_HighRatesUndiagnosed.pdf1,7 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons