Programa de Pós-Graduação em Oncologia e Ciências Médicas - PPGOCM/NPO

URI Permanente desta comunidadehttps://repositorio.ufpa.br/handle/2011/4631

O Programa de Pós-Graduação em Oncologia e Ciências Médicas (PPGOCM) integra o Núcleo de Pesquisas em Oncologia (NPO) da Universidade Federal do Pará (UFPA). Trata-se do único centro de referência em pesquisa e formação de recursos humanos stricto sensu na área de oncologia na região Norte do Brasil. Os outros centros se concentram nas cidades do Rio de Janeiro e São Paulo.

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    Dispositivo fisioterapêutico gerador de pressão positiva expiratória com propriedades fluxo-dependentes
    (Universidade Federal do Pará, 2016-12-21) NINA, Janize Costa; NORMANDO, Valéria Marques Ferreira; http://lattes.cnpq.br/7098261432975265; SILVA, Luiz Carlos Santana da; http://lattes.cnpq.br/6161491684526382
    Positive expiratory pressure therapy is safe and effective for the prevention, reversal of atelectasis and removal of pulmonary secretions. The experimental study aimed to elaborate a physiotherapeutic device capable of generating positive expiratory pressure for patients in spontaneous breathing and evaluating their mechanical performance. The composition of the physiotherapeutic device consisted of 14 components, produced in aluminum and plastic, allowing to present characteristics of a flow-dependent non-gravitational resistor. The pressures obtained through the high flux flowmeter model Certifir® FA TSI (TSI Corporated, USA) had influence of the orifice strength with diameters of 1.5, 2.0, 3.0, 4.0 and 5.0mm, five-piston weights (1.5; 1.6, 2.0, 3.2 and 3.8g) and constant flows of 3, 5, 6, 9, 10 and 12L/min or piston firing flow. Among the five pistons, the piston 4 (3.2g) presented a better statistically significant result, reaching a pressure of 20cmH2O with flows of 8.16L/min, for the 1.5mm diameter bore. The proposed PEP device can generate therapeutic pressures between 10 and 20cmH2O, through a variation of low expiratory flows. It presents as singular characteristic the association of the diameter of the orifice with the weight of the piston to generate the positive pressure. Future studies are needed in order to promote the validation of the physiotherapeutic device in healthy children and subsequent analysis in patients with pulmonary conditions to obtain scientific data that represent our clinical practice.
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    Estudo de polimorfismos no gene GRIK2 em pacientes com doença de Parkinson
    (Universidade Federal do Pará, 2017-01-18) BARBOSA, Suane Reis; SILVA, Luiz Carlos Santana da; http://lattes.cnpq.br/6161491684526382
    Parkinson's Disease (PD) is a complex neurodegenerative disorder resulting from the multiple combination of genetic and environmental factors. One of the factors that may contribute to PD development is the excitotoxicity, a pathophysiological process caused by intense stimulation of glutamatergic receptors. This neurotoxic phenomenon is associated with the excessive influx of ions in the cell (Na +, Cl- and especially Ca 2+), resulting in neuronal death. It was evidenced that the GluK2 subunit of the kainate type glutamate receptor interacts with parkin, accentuating the excitotoxic process. The GRIK2 gene encodes this subunit, expressed in regions of the brain involved in motor activity, and may undergo alternative splicing or RNA editing, introducing new isoforms that may alter the ion conductance at the receptor. There are no studies in the literature on the association of polymorphisms in the GRIK2 gene with PD. This study aimed to determine the genotypic and allelic frequencies, as well as to verify a possible influence of the SNPs rs3213607, rs2227281, rs2227283, rs2235076, rs4839797, rs2518261 from GRIK2 gene in a group of patients with PD. A case-control study was performed, with analysis of DNA samples from 129 individuals from the control group and 61 patients from the PD group. It was found that for the SNP rs2518261 (C/T), allele T appeared to have a risk effect in the DP group (x2= 19.085; p-value <0.0001; OR = 2.75; CI = 1.75-4 , 27). In this polymorphism it was also observed that TT genotype may represent a factor associated with the tremor presence in the PD group (p-value = 0.02). These pioneer results of this study, suggest that further research is needed to investigate the contribution of GRIK2 gene to PD.
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