Teses em Biologia de Agentes Infecciosos e Parasitários (Doutorado) - PPGBAIP/ICB
URI Permanente para esta coleçãohttps://repositorio.ufpa.br/handle/2011/4698
O Doutorado em Biologia de Agentes Infecciosos e Parasitários teve início em 2005 e funciona no Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários (PPGBAIP) do Instituto de Ciências Biológicas (ICB) da Universidade Federal do Pará (UFPA).
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Navegando Teses em Biologia de Agentes Infecciosos e Parasitários (Doutorado) - PPGBAIP/ICB por Orientadores "VALLINOTO, Antonio Carlos Rosário"
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Item Acesso aberto (Open Access) Correlação dos níveis séricos e dos polimorfismos nos genes de citocinas (TNF-α, INF-γ, TGF-β1 e IL-10) com a apresentação clínica da hepatite B crônica(Universidade Federal do Pará, 2010) CONDE, Simone Regina Souza da Silva; VALLINOTO, Antonio Carlos Rosário; http://lattes.cnpq.br/3099765198910740Chronic hepatitis B has a wide spectrum of clinical manifestations resulting from various factors, such as the pattern of secretion and polymorphism in cytokine genes. This work aims to correlate the TNF-α -308G/A, INF-γ +874A/T, TGF-β1 -509C/T e IL-10 -1081A/G polymorphisms and serum levels of these cytokines with the clinical presentation of hepatitis B. It was selected 53 consecutive cases of hepatitis B divided into group A (inactive carrier= 30) and B (chronic hepatitis / cirrhosis= 23). As a control, we selected 100 individuals anti-HBc and anti-HBs positives. Serum levels of cytokines were determined by enzyme immunoassays (eBiosceince, Inc. California, San Diego, USA). The gene amplification of cytokines was carried out by PCR and histopathological analysis followed by METAVIR classification. It was identified that genotype TNF-α -308GA was more prevalent among B group than controls and that presence of A allele increased the risk for chronic disease (OR= 2,6). The serum levels of INF-γ and IL-10 were higher (p <0,001) in controls than others groups A and B and the TGF-β1 levels were lower (p < 0,01) in controls. It was noted that inflammatory activity > 2 correlated with higher levels of TNF-α and IFN-γ (p<0.01) and fibrosis > 2 with higher levels of INF-γ (p <0.01). In the studied population, lower INF-γ and IL-10 levels and higher TGF-β1 level were associated with chronic hepatitis B, and that the presence TNF-α -308 A allele increased in 2,6 the risk for chronic disease .Item Acesso aberto (Open Access) Diversidade de helmintos de Ageneiosus ucayalensis Castelnau 1855 (Pisces siluriformes) da foz do Rio Guamá e Baia do Guajará, Belém, Pará(Universidade Federal do Pará, 2010-05-10) GIESE, Elane Guerreiro; SANTOS, Jeannie Nascimento dos; http://lattes.cnpq.br/4543897195525368; VALLINOTO, Antonio Carlos Rosário; http://lattes.cnpq.br/3099765198910740Descriptive taxonomy studies of fish parasites in the Amazon Region are relevant, considering the great biodiversity of known hosts. The aim of this was to analyze parasites found in Ageneiosus ucayalensis, describing new helminthes species, redescribing species and finding new hosts for species of known helminthes, using Light Microscopy, Scanning Electron Microscopy and Molecular Biology. A. ucayalensis, a fresh water siluriform from South America, is poorly studied, despite its importance in the trophic chain of fresh water environment and the great value in the regular diet of Amazonian populations. Those hosts inhabit the base level of Guamá river and Guajará Bay being parasited by helminthes of Phyla Plathyhemintes, Acanthocephala and Nematoda, which are described for the first time. In this study two new species of Nematoda were described, Procamallanus (Spirocamallanus) belenensis and Cucullanus ageneiosus; new host and new occurrence were described for Procamallanus (Spirocamallanus) rarus; moreover, we described larval forms of nematoda of Families Anisakidae (Anisakis sp.), Cystidicolidae (Pseudoproleptus sp.) and Cucullanidae (Cucullanus sp.) parasiting A. ucayalensis. Parasites of phylum Plathyhelmintes, Class Cestoda, represented by metacestodes and adults of family Proteocephalidae were also described, as well as class Monogenea, represented by helminthes of family Dactylogiridae, subfamily Ancyrocephalinae and phylum Acanthocephala by specimens of Neoechinorhynchidae, family (Genus Neoechinorhynchus). We believe that the present study contributes with important data to parasite biodiversity from Amazon Region.