Programa de Pós-Graduação em Química Medicinal e Modelagem Molecular - PPGQMMM/ICS
URI Permanente desta comunidadehttps://repositorio.ufpa.br/handle/2011/14430
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Navegando Programa de Pós-Graduação em Química Medicinal e Modelagem Molecular - PPGQMMM/ICS por Orientadores "ALVES, Claudio Nahum"
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Item Acesso aberto (Open Access) Intercalação de ácido caféico em hidróxido duplo lamelar pelo método de troca iônica: novas formulações leshimanicida(Universidade Federal do Pará, 2018-03-28) VALENTE, Jeovan do Espirito Santo; MENESES , Carla Carolina Ferreira; http://lattes.cnpq.br/3165259533988836; ALVES, Claudio Nahum; http://lattes.cnpq.br/8315600067791313; https://orcid.org/ 0000-0001-6576-4229The drug delivery systems shows several advantages when compared with traditional release systems, such as allowing the employment of lower concentrations of drug, having greater efficiency, and minimizing side effects. The improvement of drug delivery depends strictly on the choice of and adequate support allowing to effectively controlling the drug release. Thus, the use of inorganic hybrid materials, such as layered doubles hydroxides (LDH) is of great interest because of their properties. Caffeic acid (CA), coming from several natural sources, exhibits different biological activities with featured for the leishmanicidal activity. In this work, the ion exchange methodology was used for the intercalation of Caffeic acid (CA) molecules between the LDH/MgAl layers. This, in order to obtain more stable AC formulations compared to free drug. Physico-chemical characterizations were used for analysis of the structure and morphology of the hybrid compounds obtained, such as XRD, FT-IR and SEM.Item Acesso aberto (Open Access) Síntese, intercalação, caracterização estrutural e análise biológica de nanopartícula carreadora de ácido kójico(Universidade Federal do Pará, 2017-11-30) DIAS, Amarílis Aragão; SILVA, Jerônimo Lameira; http://lattes.cnpq.br/7711489635465954; https://orcid.org/ 0000-0001-7270-1517; ALVES, Claudio Nahum; http://lattes.cnpq.br/8315600067791313; https://orcid.org/ 0000-0001-6576-4229Intercalation of species with pharmacological activity in layered double hydroxides (LDHs) is a growing field in academic and industrial research, these compounds are capable of promoting the controlled release of drugs. In this work we merge the kojic acid in LDH nanoparticles of Mg2+/Al3+ by co-precipitation method. This substance has many applications in various fields of research, however it is easily susceptibile to photo-oxidation which causes organoleptic and chemical modifications of its structure. Recently kojic acid was introduced as a potent inhibitor of Leishmania cultures, we believe that the particular properties of HDL, such as photoprotection, and stabilization of the interleaved facilitate the production of a material resistant to possible applications for health. All samples were prepared by the co-precipitation method, were further characterized by X-ray diffraction, Raman, IR, UV-vis spectroscopy, thermogravimetry, and biological evaluations of Leishmania cultures. Our results demonstrate that HDL has 53.018% AK intercalated kojic acid and is able to withstand high temperatures, in addition to having an anti-leishmania potential.