Programa de Pós-Graduação em Oncologia e Ciências Médicas - PPGOCM/NPO

URI Permanente desta comunidadehttps://repositorio.ufpa.br/handle/2011/4631

O Programa de Pós-Graduação em Oncologia e Ciências Médicas (PPGOCM) integra o Núcleo de Pesquisas em Oncologia (NPO) da Universidade Federal do Pará (UFPA). Trata-se do único centro de referência em pesquisa e formação de recursos humanos stricto sensu na área de oncologia na região Norte do Brasil. Os outros centros se concentram nas cidades do Rio de Janeiro e São Paulo.

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Agora exibindo 1 - 4 de 4

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Efeito da suplementação de altas doses de colecalciferol sobre o comportamento da pressão arterial em pacientes normotensos com diabetes mellitus tipo 1
(Universidade Federal do Pará, 2018-12-26) QUEIROZ, Natércia Neves Marques de; FELÍCIO, João Soares; http://lattes.cnpq.br/8482132737976863
Type 1 diabetes mellitus is an endocrine disease highly associated to cardiovascular (CV) risk. Vitamin D (VD) deficiency has been associated to a burden of chronic diseases due to the presence of vitamin D receptors (VDR) through diverse human tissues such as smooth vascular muscle, endothelium, cardiomiocytes and juxtaglomerular cells. Some studies have suggested an inverse relationship between vitamin D levels and blood pressure. High mean blood pressure levels have been found in vitamin D deficient patients. Additionally, previous studies have suggested that the VD-VDR complex might act as a negative regulator factor over renin angiotensin system, which could be responsible for positive effects on blood pressure. The main objective of this study was to evaluate high doses vitamin D supplementation effects on blood pressure of normotensive T1DM patients. Our study was a prospective interventionist study in 35 T1DM patients. The patients with vitamin D lower them 30ng/ml received 10.000UI/daily e if was 30-60 ng/ml was gave 4.000UI/daily. They made 24-hour ambulatory blood pressure monitoring, gycated hemoglobin, creatin, lipids profile, PCRus, before and after 12 weeks. We found an expressing reduce of systolic and diastolic morning blood pressures (117 ± 14 vs 112±14, p<0,05; 74±9 vs 70±10 mmHg, p<0,05, respectively) with no changes in order pressoric markers. Besides, we notice correlation between levels of VD after supplementation and diastolic morning blood pressure (r= -0,4; p<0.05). In conclusion, our study suggest that was an association with supplementation of high doses of vitamin D and reduce of morning blood pressure in normotensives type 1 diabetes mellitus patients.
Acesso aberto (Open Access)
Efeito da suplementação de altas doses de vitamina D sobre a neuropatia autonômica cardiovascular em pacientes com diabetes mellitus tipo 1
(Universidade Federal do Pará, 2018-12-10) SILVA, Lilian de Souza d’Albuquerque; FELÍCIO, João Soares; http://lattes.cnpq.br/8482132737976863; YAMADA, Elizabeth Sumi; http://lattes.cnpq.br/7240314827308306
Cardiovascular autonomic neuropathy (CAN), associated with diabetes mellitus (DM), despite being a subclinical condition, is an important morbidity and mortality factor in these patients. In type 1 diabetes mellitus (DM1) CAN is so alarming that it must be screened after the first 5 years of illness. Few therapeutic measures are recommended in international guidelines on the subject. Some authors have been studying drugs that can modified natural history of disease and then improve outcomes. Vitamin D seems promising resource and low cost. The aim of our study was to evaluate the effects of high-dose vitamin D (DV) supplementation on CAN in patients with DM1. We performed a prospective, interventional study in which 17 patients diagnosed with DM1 and CAN were included. Patients with VD levels below 30 ng / mL received 10,000 IU / day, and when 30-60 ng / mL, they used 4,000 IU / day. Serum VD dosage and CAN tests were performed before and after 12 weeks of treatment. There was an improvement in the parameters related to resting heart rate (HR) variability, which were: LF (1.9 ± 0.4 vs 2.2 ± 0.7 sec, p = 0.05), TP (2.5 ± 0.3 vs 2.7 ± 0.5 sec, p <0.05) , RRmax (0.8 ± 0.09 vs 0.9 ± 0.23 sec, p <0.05), RRNN (0.72 ± 0.09 vs 0.76 ± 0.09 sec, p <0.05) and SDNN (0.015 ± 0.005 vs 0.026 ± 0.018 sec; p <0.05). In addition, it was demonstrated that the variation of the RV level correlated with both the final HF (after treatment) and the LF / HF ratio (r = 0.57, p <0.05). Our pilot study is the first to suggest a strong association between high-dose vitamin D supplementation and improved cardiovascular autonomic neuropathy in DM1 patients. This occurred without any variation in HbA1C, blood pressure levels, lipids and insulin doses used
Acesso aberto (Open Access)
Influência da suplementação de altas doses de vitamina D no controle glicêmico em pacientes com diabetes mellitus tipo 1
(Universidade Federal do Pará, 2018-12-10) MELO, Franciane Trindade Cunha de; FELÍCIO, João Soares; http://lattes.cnpq.br/8482132737976863; YAMADA, Elizabeth Sumi; http://lattes.cnpq.br/7240314827308306
Although the intensive glycemic control of Diabetes Mellitus (DM) with insulin has reduced the incidence of microvascular and macrovascular complications, most patients still develop these injuries with high morbidity and mortality. It has been suggested that low levels of vitamin D (VD) may be associated with the development of Type 1 diabetes mellitus (DM1) and poor glycemic control. As a therapeutic potential, the use of VD in patients with DM1 has presented controversial results regarding the reduction of glucose levels. The objective of this study is to analyze the effects of high-dose vitamin D supplementation on glycemic control of patients with DM1, assessed through glycated hemoglobin levels (HbA1c). A prospective, 12week clinical trial including 52 patients with DM1, which were supplemented with high doses of cholecalciferol, was performed. The dose used for this vitamin was according to the participant's VD value. Patients with VD levels below 30 ng / mL received 10,000 IU / day, and when 30-60 ng / mL, they used 4,000 IU / day. The levels of VD and HbA1c were evaluated before and after 3 months of vitamin supplementation. When we analyzed the total number of patients (N = 52), there was no improvement in the glycemic control evaluated by HbA1c ((9.3 ± 2.3 vs 9.5 ± 2.4, p=NS). To better study the effects of VD on HbA1c, patients were divided into 3 groups according to HbA1c variation: those whose HbA1c reduced ≥ 0.5% (group 1, N = 14); those with no variation in HbA1c (group 2, N = 19) and those with ≥ 0.5% increase in HbA1c (group 3, N = 24). There was a decrease in HbA1c in only one specific group (N = 14). In addition, there was no reduction in prandial basal insulin needs or full dose after three months of VD supplementation. Thus, our data suggest that there is no additional benefit of VD supplementation in the optimization of glycemic control evaluated by HbA1C in patients with DM1.
Acesso aberto (Open Access)
Modelo murino do espectro autista empregando o ácido valproico durante a gravidez: mudanças comportamentais e citocinas pró-inflamatórias
(Universidade Federal do Pará, 2018-10-31) SOUZA, Dilza Nazaré Colares de; DINIZ, Cristovam Wanderley Picanço; http://lattes.cnpq.br/2014918752636286; DINIZ, Daniel Guerreiro; http://lattes.cnpq.br/3269424921125406
The present study evaluated, in behavioral tests, the exploratory and locomotor activities of young adult BALB/c mice that were exposed to valproic acid during pregnancy and measured their proinflammatory cytokines concentration in peripheral blood. To this end, we exposure females to males and on day 12.5 of gestation, females received 0.2 mL of VPA diluted in saline (600 mg / kg body weight) or equal volume of saline solution. The pups were weaned on the 21st postnatal day and the males were kept either in the impoverished environment of standard laboratory cages (IE) or in an enriched cage (EE). Four independent experimental groups according to experimental condition and environment (Ctrl / EE, Ctrl / IE, VPA / EE, VPA / IE) were organized. At 5 months of age, all animals were submitted to Open Field (OF), Episodic Memory (EM), Burrowing and Elevated Plus Maze (EPM) tests and had their peripheral blood collected and then perfused with saline followed by aldehyde fixatives. Two-way ANOVA revealed significant influences of experimental condition (VPA vs. Saline) and environment (EE vs IE) on behavioral outcomes and on proinflammatory cytokines peripheral concentrations. In the open field, the valproic acid groups, regardless of the environment where they were kept, reversed the natural tendency to avoid the center of the arena, F (1,54) = 5.59, p = 0.022. Similarly, in the elevated plus maze, the valproic acid groups, independent of the environment where the animals were kept, showed a significant influence on the time spent in the central platform, reducing it significantly, F (1,51) = 7.57, p = 0.0082. Two-way ANOVA also demonstrated a significant influence of the experimental condition (VPA vs. Saline) on the immune response reducing IL-1β, F (1.49) = 26.24, p <0.0001 and increasing IL-6, F (1.46) = 16.96, p = 0.0002 of the valproic acid groups. BALB/c mice exposed to valproic acid during pregnancy shows significant changes on their behavior to explore novel environments and to assess risk at adulthood, and this is associated with proinflammatory cytokines peripheral changes. Somatosensory and cognitive stimulation of environmental enrichment seems to be not enough to reverse it.

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