Artigos Científicos - FEQ/ITEC

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Inibição e reversão da agregação plaquetária de eqüinos in vitro com o uso de ketoprofeno, fenilbutazona e flunixim meglumine
(2009-10) LEME, Fabiola de Oliveira Paes; WURZINGER, Laurenz; ALVES, Geraldo Eleno Silveira; BICALHO, Adriane Pimenta da Costa-Val; BARBOSA, Marcos Pinott; PAES, Paulo Ricardo de Oliveira; OLIVEIRA, Marcos Enê Chaves
Several diseases may lead to platelet pre-activation and hypercoagulability states in horses. The activity of many drugs against platelet aggregation may, not only contribute to the evaluation of a disease but also its response to the therapy. With the aim to study in vitro prevention and reversion of platelet aggregation, the non steroidal anti-inflammatory drug (NSAID): ketoprophen, phenylbutazone and flunixin-meglumin were evaluated. The comparison demonstrated that phenylbutazone and ketoprophen prevented platelet aggregation induced by ADP better than flunixin-meglumin, in a superior manner to the monoclonal antibody Reopro, and in a better way than the membrane receptor blockers Ro-438857 and RGDS. The reversion of platelet aggregation demonstrated that even phenylbutazone or ketoprophen have a dose-dependent effect.