NMT - Núcleo de Medicina Tropical

URI Permanente desta comunidadehttps://repositorio.ufpa.br/handle/2011/2211

Navegar

Agora exibindo 1 - 4 de 4

Acesso aberto (Open Access)
Avaliação da contaminação mercurial mediante análise do teor de Hg total em amostras de cabelo em comunidades ribeirinhas do Tapajós, Pará, Brasil
(2000-04) PINHEIRO, Maria da Conceição Nascimento; GUIMARÃES, Geraldo de Assis; NAKANISHI, Junko; OIKAWA, Teiichi; VIEIRA, José Luiz Fernandes; QUARESMA, Manoel; CARDOSO, Bernardo da Silva; AMORAS, Walter Wanderley
This study evaluates human exposure to methylmercury in fishermen and their families in four villages on the Tapajós river: Rainha, Barreiras, São Luís do Tapajós and Paraná-Mirim. Hair analyses were performed with atomic absorption spectophotometry. Total hair mercury levels varied between 2.9mg/g and 71.5mg/g. Paraná-Mirim showed the lowest level. The highest level was found in São Luís do Tapajós and Barreiras. The hair mercury was six to seven times higher than the established safe limit of 10mg/g. No statistically significant difference was found between the mean level of total mercury taken from the inhabitants living downstream and upstream in Itaituba village (p > 0.05). These results confirm that human exposure to methylmercury is occurring on the Tapajós river and suggest that continued fish ingestion in that region is a potential risk factor for the appearance of symptoms and signs of Minamata disease. An immediate epidemiological survey program is recommended.
Acesso aberto (Open Access)
Comparative study of human exposure to mercury in riverside communities in the Amazon region
(2006-03) PINHEIRO, Maria da Conceição Nascimento; OIKAWA, Teiichi; VIEIRA, José Luiz Fernandes; GOMES, M S V; GUIMARÃES, Geraldo de Assis; CRESPO LÓPEZ, Maria Elena; MÜLLER, Regina Celi Sarkis; AMORAS, Walter Wanderley; RIBEIRO, Danielle Regina Gomes; RODRIGUES, Anderson Raiol; CÔRTES, Maria Izabel Tentes; SILVEIRA, Luiz Carlos de Lima
Four populations in the Amazon area were selected for a comparative study of mercury-exposed and non-exposed populations: São Luiz do Tapajós, Barreiras, Panacauera, and Pindobal Grande. The highest mercury levels in human hair samples were found in São Luiz do Tapajós and Barreiras, greatly exceeding the limits established by the World Health Organization. Panacauera showed an intermediate level below 9 µg/g. This was the first comparative and simultaneous evaluation of mercury exposure in the Amazon area. Also, thanks to this type of monitoring, we were able to eliminate the uncertainties about the reference dose. On the basis of these data, we can conclude that the mercury levels detected in exposed populations of the Tapajós River basin may be dangerous not only because they are above the World Health Organization limits, but also because the simultaneous mercury detection in non-exposed populations with similar characteristics provided a valid control and revealed lower mercury levels. Our results support the importance of continuous monitoring in both exposed and non-exposed populations.
Acesso aberto (Open Access)
Estudo da eficácia e tolerância do artesunato oral isolado e em associação com mefloquina, no tratamento da malária falciparum não complicada em área endêmica do Pará, Brasil
(1996-06) CARDOSO, Bernardo da Silva; DOURADO, Heitor Vieira; PINHEIRO, Maria da Conceição Nascimento; CRESCENTE, Jose Angelo Barletta; AMORAS, Walter Wanderley; BAENA, Jorge; SARATY, Sandra
With the objective to evaluate the efficacy and tolerance of artesunate in the treatment of non-complicatedfalciparum malaria in endemic area of the State of Pará, 153 patients were randomized and studied in three groups, distributed by therapeutical scheme (I received mefloquine lOOOmg, II used artesunate 600mg followed by mefloquine 500mg). Evaluation was made by daily clinical and parasithological examination, in the first 7 days, and weekly until the 35th day of the follow up. Biochemical and hematological analysis previously done and on the 7th day, targetting cure control and identification of possible effects related to drugs administration. As to sex, parasitemy and fever, studied groups were homogeneous. Time for parasitemy disappearence was shorter in the groups II and III respectively, whose therapeutical schemes had artesunate. Fever disappereance was quicker in the group treated with the combination of drugs. Clinical and biochemical alterations associated with drugs administration did not show significant differences among the studied groups. Early disappearence of fever and parasitemy, and absence of important side effects suggest that artesunate, isolated or administrated in combination with mefloquine, constitutes an able therapeutical procedure to contribute for disease control in that region.
Acesso aberto (Open Access)
Exposição humana ao metilmercúrio em comunidades ribeirinhas da Região do Tapajós, Pará, Brasil
(2000-06) PINHEIRO, Maria da Conceição Nascimento; NAKANISHI, Junko; OIKAWA, Teiichi; GUIMARÃES, Geraldo de Assis; QUARESMA, Manoel; CARDOSO, Bernardo da Silva; AMORAS, Walter Wanderley; HARADA, Masazume; MAGNO, Carlos; VIEIRA, José Luiz Fernandes; XAVIER, Marília Brasil; BACELAR, Maria Denise Ribeiro
Evaluation of total human exposure to mercury and methylmercury was effected in riverine villages along the Tapajos river and in the metropolitan area of Belem city, state of Para, Brazil, by using total mercury and methylmercury concentrations in hair samples in 1994 and 1995. It was observed that average concentrations of total mercury are in a range from 2 ± 1µg/g-1 to 20.5 ± 12.1µg/g-1. While methylmercury average concentration varies from 1.4 ± 0.7µg/g-1 to 18.5 ± 11µg/g-1. These results confirm mercury contamination in the Tapajos river and possible appearance of mercury intoxication symptoms, and recommends the monitoring of compounds in hair samples as well as the need for epidemiological and clinical studies for human health prevention and control of mercury intoxication.

Navegar

Navegando NMT - Núcleo de Medicina Tropical por Autor "AMORAS, Walter Wanderley"