Navegando por Autor "BARBOSA, Maria Silvanira Ribeiro"

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Acesso aberto (Open Access)
CDH1 mutations in gastric cancer patients from northern Brazil identified by Next- Generation Sequencing (NGS)
(Universidade Federal do Pará, 2016-06) EL HUSNY, Antonette Souto; MORAES, Milene Raiol de; AMADOR, Marcos Antônio Trindade; SANTOS, André Maurício Ribeiro dos; MONTAGNINI, Andre Luis; BARBOSA, Maria Silvanira Ribeiro; SILVA, Artur Luiz da Costa da; ASSUMPÇÃO, Paulo Pimentel de; ISHAK, Geraldo; SANTOS, Sidney Emanuel Batista dos; PINTO, Pablo Diego do Carmo; CRUZ, Aline Maria Pereira; SANTOS, Ândrea Kely Campos Ribeiro dos
Gastric cancer is considered to be the fifth highest incident tumor worldwide and the third leading cause of cancer deaths. Developing regions report a higher number of sporadic cases, but there are only a few local studies related to hereditary cases of gastric cancer in Brazil to confirm this fact. CDH1 germline mutations have been described both in familial and sporadic cases, but there is only one recent molecular description of individuals from Brazil. In this study we performed Next Generation Sequencing (NGS) to assess CDH1 germline mutations in individuals who match the clinical criteria for Hereditary Diffuse Gastric Cancer (HDGC), or who exhibit very early diagnosis of gastric cancer. Among five probands we detected CDH1 germline mutations in two cases (40%). The mutation c.1023T > G was found in a HDGC family and the mutation c.1849G > A, which is nearly exclusive to African populations, was found in an early-onset case of gastric adenocarcinoma. The mutations described highlight the existence of gastric cancer cases caused by CDH1 germline mutations in northern Brazil, although such information is frequently ignored due to the existence of a large number of environmental factors locally. Our report represent the first CDH1 mutations in HDGC described from Brazil by an NGS platform.
Acesso aberto (Open Access)
Complete genome sequence of Corynebacterium pseudotuberculosis biovar ovis strain P54B96 isolated from antelope in South Africa obtained by rapid next generation sequencing technology
(BioMed Central, 2012) HASSAN, Syed Shah; GUIMARÃES, Luís Carlos; PEREIRA, Ulisses de Pádua; ISLAM, Arshad; ALI, Amjad; BAKHTIAR, Syeda Marriam; RIBEIRO, Dayana; SANTOS, Anderson Rodrigues dos; SOARES, Siomar de Castro; DORELLA, Fernanda Alves; GOMIDE, Anne Cybelle Pinto; SCHNEIDER, Maria Paula Cruz; BARBOSA, Maria Silvanira Ribeiro; ALMEIDA, Sintia Silva de; ABREU, Vinicius Augusto Carvalho de; ABURJAILE, Flavia Figueira; CARNEIRO, Adriana Ribeiro; CERDEIRA, Louise Teixeira; NASCIMENTO, Karina Kelly Fiaux do; BARBOSA, Eudes Guilherme Vieira; DINIZ, Carlos Augusto Almeida; ROCHA, Flávia de Souza; RAMOS, Rommel Thiago Juca; JAIN, Neha; TIWARI, Sandeep; BARH, Debmalya; MIYOSHI, Anderson; MÜLLER, Borna; SILVA, Artur Luiz da Costa da; AZEVEDO, Vasco Ariston de Carvalho
The Actinobacteria, Corynebacterium pseudotuberculosis strain P54B96, a nonmotile, non sporulating and a mesophile bacterium, was isolated from liver, lung and mediastinal lymph node lesions in an antelope from South Africa. This strain is interesting in the sense that it has been found together with non-tuberculous mycobacteria (NTMs) which could nevertheless play a role in the lesion formation. In this work, we describe a set of features of C. pseudotuberculosis P54B96, together with the details of the complete genome sequence and annotation. The genome comprises of 2.34 Mbp long, single circular genome with 2,084 protein-coding genes, 12 rRNA, 49 tRNA and 62 pseudogenes and a G+C content of 52.19%. The analysis of the genome se quence provides means to better understanding the molecular and genetic basis of virulence of this bacterium, enabling a detailed investigation of its pathogenesis.
Acesso aberto (Open Access)
Complete genome sequence of Corynebacterium pseudotuberculosis I19, a strain isolated from a cow in Israel with bovine mastitis
(American Society for Microbiology, 2011-01) SILVA, Artur Luiz da Costa da; SCHNEIDER, Maria Paula Cruz; CERDEIRA, Louise Teixeira; BARBOSA, Maria Silvanira Ribeiro; RAMOS, Rommel Thiago Juca; CARNEIRO, Adriana Ribeiro; OLIVEIRA, Rodrigo Santos de; LIMA, Margarida Maria Celeira de; CONCEIÇÃO, Marília Lima da; FERREIRA, Vívian D'Afonseca da Silva; ALMEIDA, Sintia Silva de; SANTOS, Anderson Rodrigues dos; SOARES, Siomar de Castro; GOMIDE, Anne Cybelle Pinto; ALI, Amjad; DORELLA, Fernanda Alves; ROCHA, Flávia de Souza; ABREU, Vinicius Augusto Carvalho de; TROST, Eva; TAUCH, Andreas; SHPIGEL, Nahum; MIYOSHI, Anderson; AZEVEDO, Vasco Ariston de Carvalho
This work reports the completion and annotation of the genome sequence of Corynebacterium pseudotuberculosis I19, isolated from an Israeli dairy cow with severe clinical mastitis. To present the whole-genome sequence, a de novo assembly approach using 33 million short (25-bp) mate-paired SOLiD reads only was applied. Furthermore, the automatic, functional, and manual annotations were attained with the use of several algorithms in a multistep process.
Acesso aberto (Open Access)
Complete Genome Sequence of Corynebacterium pseudotuberculosis Strain 1/06-A, Isolated from a Horse in North America
(American Society for Microbiology, 2012-08) PETHICK, Florence E.; LAINSON, Alex F.; YAGA, Raja; FLOCKHART, Allen; SMITH, David G. E.; DONACHIE, Willie; CERDEIRA, Louise Teixeira; SILVA, Artur Luiz da Costa da; BOL, Erick Johny Maciel; LOPES, Thiago Souza; BARBOSA, Maria Silvanira Ribeiro; GOMIDE, Anne Cybelle Pinto; SANTOS, Anderson Rodrigues dos; SOARES, Siomar de Castro; ALMEIDA, Sintia Silva de; GUIMARÃES, Luís Carlos; ABURJAILE, Flavia Figueira; ABREU, Vinicius Augusto Carvalho de; RIBEIRO, Dayana; NASCIMENTO, Karina Kelly Fiaux do; DINIZ, Carlos Augusto Almeida; BARBOSA, Eudes Guilherme Vieira; PEREIRA, Ulisses de Pádua; HASSAN, Syed Shah; ALI, Amjad; BAKHTIAR, Syeda Marriam; DORELLA, Fernanda Alves; CARNEIRO, Adriana Ribeiro; RAMOS, Rommel Thiago Juca; ROCHA, Flávia de Souza; SCHNEIDER, Maria Paula Cruz; MIYOSHI, Anderson; AZEVEDO, Vasco Ariston de Carvalho; FONTAINE, Michael C.
Corynebacterium pseudotuberculosis causes disease in several animal species, although distinct biovars exist that appear to be restricted to specific hosts. In order to facilitate a better understanding of the differences between biovars, we report here the complete genome sequence of the equine pathogen Corynebacterium pseudotuberculosis strain 1/06-A.
Acesso aberto (Open Access)
Complete genome sequences of Corynebacterium pseudotuberculosis Strains 3/99-5 and 42/02-A, isolated from sheep in Scotland and Australia, respectively
(American Society for Microbiology, 2012-09) PETHICK, Florence E.; LAINSON, Alex F.; YAGA, Raja; FLOCKHART, Allen; SMITH, David G. E.; DONACHIE, Willie; CERDEIRA, Louise Teixeira; SILVA, Artur Luiz da Costa da; BOL, Erick Johny Maciel; LOPES, Thiago Souza; BARBOSA, Maria Silvanira Ribeiro; GOMIDE, Anne Cybelle Pinto; SANTOS, Anderson Rodrigues dos; SOARES, Siomar de Castro; ALMEIDA, Sintia Silva de; GUIMARÃES, Luís Carlos; ABURJAILE, Flavia Figueira; ABREU, Vinicius Augusto Carvalho de; RIBEIRO, Dayana; NASCIMENTO, Karina Kelly Fiaux do; DINIZ, Carlos Augusto Almeida; BARBOSA, Eudes Guilherme Vieira; PEREIRA, Ulisses de Pádua; HASSAN, Syed Shah; ALI, Amjad; BAKHTIAR, Syeda Marriam; DORELLA, Fernanda Alves; CARNEIRO, Adriana Ribeiro; RAMOS, Rommel Thiago Juca; ROCHA, Flávia de Souza; SCHNEIDER, Maria Paula Cruz; MIYOSHI, Anderson; AZEVEDO, Vasco Ariston de Carvalho; FONTAINE, Michael C.
Here, we report the whole-genome sequences of two ovine-pathogenic Corynebacterium pseudotuberculosisisolates: strain 3/99-5, which represents the first C. pseudotuberculosis genome originating from the United Kingdom, and 42/02-A, the second from Austra lia. These genome sequences will contribute to the objective of determining the global pan-genome of this bacterium.
Acesso aberto (Open Access)
Whole-Genome Sequence of Corynebacterium pseudotuberculosis PAT10 Strain Isolated from Sheep in Patagonia, Argentina
(American Society for Microbiology, 2011-11) CERDEIRA, Louise Teixeira; GOMIDE, Anne Cybelle Pinto; SCHNEIDER, Maria Paula Cruz; ALMEIDA, Sintia Silva de; SANTOS, Anderson Rodrigues dos; BARBOSA, Eudes Guilherme Vieira; ALI, Amjad; BARBOSA, Maria Silvanira Ribeiro; CARNEIRO, Adriana Ribeiro; RAMOS, Rommel Thiago Juca; OLIVEIRA, Rodrigo Santos de; BARH, Debmalya; SHARMA, Neha Barve; ZAMBARE, Vasudeo; BELCHIOR, Silvia Estevão; GUIMARÃES, Luís Carlos; SOARES, Siomar de Castro; DORELLA, Fernanda Alves; ROCHA, Flávia de Souza; ABREU, Vinicius Augusto Carvalho de; TAUCH, Andreas; TROST, Eva; MIYOSHI, Anderson; AZEVEDO, Vasco Ariston de Carvalho; SILVA, Artur Luiz da Costa da
In this work, we report the complete genome sequence of a Corynebacterium pseudotuberculosis PAT10 isolate, collected from a lung abscess in an Argentine sheep in Patagonia, whose pathogen also required an investigation of its pathogenesis. Thus, the analysis of the genome sequence offers a means to better understanding of the molecular and genetic basis of virulence of this bacterium.
Acesso aberto (Open Access)
Whole-Genome Sequence of Corynebacterium pseudotuberculosis Strain Cp162, Isolated from Camel
(American Society for Microbiology, 2012) HASSAN, Syed Shah; SCHNEIDER, Maria Paula Cruz; RAMOS, Rommel Thiago Juca; CARNEIRO, Adriana Ribeiro; LIMA, Alex Ranieri Jerônimo; GUIMARÃES, Luís Carlos; ALI, Amjad; BAKHTIAR, Syeda Marriam; PEREIRA, Ulisses de Pádua; SANTOS, Anderson Rodrigues dos; SOARES, Siomar de Castro; DORELLA, Fernanda Alves; GOMIDE, Anne Cybelle Pinto; RIBEIRO, Dayana; BARBOSA, Maria Silvanira Ribeiro; ALMEIDA, Sintia Silva de; ABREU, Vinicius Augusto Carvalho de; ABURJAILE, Flavia Figueira; NASCIMENTO, Karina Kelly Fiaux do; BARBOSA, Eudes Guilherme Vieira; DINIZ, Carlos Augusto Almeida; ROCHA, Flávia de Souza; SAXENA, Rashmi; TIWARI, Sandeep; ZAMBARE, Vasudeo; GHOSH, Preetam; PACHECO, Luis Gustavo Carvalho; DOWSON, Christopher G.; KUMAR, Anil; BARH, Debmalya; MIYOSHI, Anderson; AZEVEDO, Vasco Ariston de Carvalho; SILVA, Artur Luiz da Costa da
Corynebacterium pseudotuberculosis is a pathogen of great veterinary and economic importance, since it affects livestock, mainly sheep and goats, worldwide, together with reports of its presence in camels in several Arabic, Asiatic, and East and West African countries, as well as Australia. In this article, we report the genome sequence of Corynebacterium pseudotuberculosis strain Cp162, collected from the external neck abscess of a camel in the United Kingdom.