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Navegando por Autor "BRITES, Carlos Roberto"

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    Establishing the reference range for t lymphocytes subpopulations in adults and children from Brazil
    (2013-10) TORRES, Alex José Leite; ANGELO, Ana Luiza Dias; SILVA, Márcio de Oliveira; BASTOS, Milena de Carvalho; SOUZA, Denise Ferreira de; INOCÊNCIO, Lílian do Amaral; LEMOS, José Alexandre Rodrigues de; SOUZA JÚNIOR, Ruy de; CASTRO, Andréa Cauduro de; PALMA, Patrícia Vianna Bonnini; CECI, Loredana; MARTINS NETTO, Eduardo; BRITES, Carlos Roberto
    In Brazil, the existing reference values for T-lymphocytes subsets are based on data originated in other countries. There is no local information on normal variation for these parameters in Brazilian adults and children. We evaluated the normal variation found in blood donors from five large Brazilian cities, in different regions, and in children living in Salvador, and Rio de Janeiro. All samples were processed by flow cytometry. The results were analyzed according to region, gender, and lifestyle of blood donors. A total of 641 adults (63% males), and 280 children (58% males) were involved in the study. The absolute CD3+, and CD4+ cells count were significantly higher for females (adults and children). Higher CD4+ cell count in adults was associated with smoking, while higher CD8+ count was found among female children. Higher counts, for all T-cells subsets, were detected in blood donors from southeast / south regions while those living in the northern region had the lowest values. Individuals from midwestern and northeastern regions had an intermediate count for all these cells subsets. However, these differences did not reach statistical significance. In Brazil, gender and smoking, were the main determinants of differences in T-lymphocytes reference values.
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    Reference range for T lymphocytes populations in blood donors from two different regions in Brazil
    (2009-06) TORRES, Alex José Leite; ANGELO, Ana Luiza Dias; MARTINS NETTO, Eduardo; SAMPAIO, Geraldo Pedral; SOUZA, Denise Ferreira de; INOCÊNCIO, Lílian do Amaral; LEMOS, José Alexandre Rodrigues de; BRITES, Carlos Roberto
    This study defined the normal variation range for different subsets of T-lymphocyte cells count in two different Brazilian regions. We analysed the T-lymphocytes subpopulations (CD3+, CD4+, CD8+) in blood donors of two Brazilian cities, located in North (Belem, capital state of Para, indian background) and Northeast (Salvador, capital state od Bahia, African background) regions of Brazil. Results were compared according to gender, stress level (sleep time lower than 8 hours/day), smoking, and alcohol intake. Lymphocytes subpopulations were measured by flow cytometry. Five hundred twenty-six blood donors from two Brazilians cities participated in the study: 450 samples from Bahia and 76 samples from Pará. Most (60%) were men, 59% reported alcohol intake, 12% were smokers, and 80% slept at least 8 h/day. Donors from Bahia presented with significantly higher counts for all parameters, compared with Para. Women had higher lymphocytes levels, in both states, but only CD4+ cells count was significantly higher than men's values. Smokers had higher CD4+ counts, but sleep time had effect on lymphocytes levels only for Para's donors (higher CD3+ and CD4+ counts). That state had also, a higher proportion of donors reporting sleep time <8 h/day. The values for CD3, CD4 and CD8+ cells count were significantly higher in blood donors from Bahia than among those from Pará. Female gender, alcohol intake, stress level, and smoking were associated with higher lymphocyte counts. The use of a single reference range for normal lymphocytes count is not appropriate for a country with such diversity, like Brazil is.
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