Navegando por Autor "MONTEIRO, Marta Chagas"

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Acesso aberto (Open Access)
Clinical applications and methemoglobinemia induced by dapsone
(2014-10) OLIVEIRA, Fábio Rodrigues de; PESSÔA, Mariely Cristine Amador; ALBUQUERQUE, Rosyana de Fatima Vieira de; SCHALCHER, Taysa Ribeiro; MONTEIRO, Marta Chagas
Dapsone is a synthetic sulfone that is used as an antibiotic in humans and animals to prevent and treat diseases including leprosy, tuberculosis, malaria, and Pneumocystis carinii pneumonia and Toxoplasma gondii encephalitis in acquired immune deficiency syndrome (AIDS) patients as well as in anti-inflammatory conditions, such as dermatitis herpetiformis. However, this drug is also associated with several adverse effects, including dose-related hemolysis, methemoglobinemia, psychosis, peripheral neuropathy, agranulocytosis, aplastic anemia, hypersensitivity syndrome, sulfone syndrome, and others. Of these effects, methemoglobinemia is the most common side effect of dapsone, which leads to functional anemia and cellular hypoxia with symptoms of cyanosis, headache, fatigue, tachycardia, weakness, and dizziness. Thus, this review summarizes relevant information on the structure, mechanism of action, clinical indication, and adverse reactions of dapsone.
Acesso aberto (Open Access)
Comparison of the effects of brazil nut oil and soybean oil on the cardiometabolic parameters of patients with metabolic syndrome: a randomized trial
(Multidisciplinary Digital Publishing Institute, 2020) SILVA, Lívia Martins Costa e; MELO, Maria Luisa Pereira de; REIS, Fernando Vinícius Faro; MONTEIRO, Marta Chagas; SANTOS, Sávio Monteiro dos; GOMES, Bruno Alexandre Quadros; SILVA, Luiza Helena Meller da
Recent evidence suggests that replacing saturated fat with unsaturated fat is beneficial for cardiovascular health. This study compared the effects of Brazil nut oil (BNO) and soybean oil (SO) supplementation for 30 days on anthropometric, blood pressure, biochemical, and oxidative parameters in patients with metabolic syndrome (MS). Thirty-one patients with MS were randomly allocated to receive 30 sachets with 10 mL each of either BNO (n = 15) or SO (n = 16) for daily supplementation. Variables were measured at the beginning of the study and after 30 days of intervention. No change in anthropometric and blood pressure variables were observed (p > 0.05). Total (p = 0.0253) and low-density lipoprotein (p = 0.0437) cholesterol increased in the SO group. High-density lipoprotein cholesterol decreased (p = 0.0087) and triglycerides increased (p = 0.0045) in the BNO group. Malondialdehyde levels decreased in the BNO group (p = 0.0296) and total antioxidant capacity improved in the SO group (p = 0.0110). Although the addition of oils without lifestyle interventions did not affect anthropometric findings or blood pressure and promoted undesirable results in the lipid profile in both groups, daily supplementation of BNO for 30 days decreased lipid peroxidation, contributing to oxidative stress reduction.
Acesso aberto (Open Access)
Fatores de risco associados ao agravamento de sepse em pacientes em Unidade de Terapia Intensiva
(Universidade Federal do Pará, 2016-12) BARROS, Lea Lima dos Santos; MAIA, Cristiane do Socorro Ferraz; MONTEIRO, Marta Chagas
Introduction: sepsis is a serious public health problem, leading cause of death in Intensive Care Unit (ICU) worldwide. Objective: this study evaluated the aggravation and mortality of sepsis patients in ICU, relating to risk factors, different etiologies and therapies. Methodology: the study was observational descriptive, and evaluated the cases of sepsis (sepsis, severe sepsis and septic shock) from January 2009 to December 2010. Results: of the 212 patients hospitalized in ICU, 181 presented sepsis at different severities, whose sepsis mortality in the ICU was 63%, especially in patients with septic shock (53%), followed by severe sepsis (8.3%). Moreover, the risk factors associated with the aggravation of sepsis were older than 65 years, longer ICU hospitalization time, high frequency of comorbidities and the use of invasive procedures. The highest consumption of antibiotics was carbapenems, and the main isolated multiresistant strains were MRSA, VRE, P. aeruginosa and A. baumannii resistant to carbapenems. Conclusion: this study showed a high mortality from sepsis patients in the ICU, especially in patients with septic shock with comorbidities, who underwent invasive procedures and longer hospitalization time.