Navegando por Autor "SILVA, Jorge Pereira da"

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Acesso aberto (Open Access)
Isolation of Fonsecaea pedrosoi from thorns of Mimosa pudica, a probable natural source of chromoblastomycosis
(2004-02) SALGADO, Claudio Guedes; SILVA, Jorge Pereira da; DINIZ JUNIOR, José Antônio Picanço; SILVA, Moisés Batista da; COSTA, Patricia Fagundes da; TEIXEIRA, Cláudio Eduardo Corrêa; SALGADO, Ubirajara Imbiriba
We report the isolation of Fonsecaea pedrosoi from thorns of the plant Mimosa pudica L. at the place of infection identified by one of our patients. Clinical diagnosis of chromoblastomycosis was established by direct microscopic examination and cultures from the patient's lesion. The same species was isolated from the patient and from the plant. Scanning electron microscopy of the surface of the thorns showed the characteristic conidial arrangement of F. pedrosoi. These data indicate that M. pudica could be a natural source of infection for the fungus F. pedrosoi.
Acesso aberto (Open Access)
Methemoglobinemia and dapsone levels in patients with leprosy
(2010-06) VIEIRA, José Luiz Fernandes; RIVERA, Juan Gonzalo Bardález; MARTINS, Ana de Nazaré Silva; SILVA, Jorge Pereira da; SALGADO, Claudio Guedes
The objective of this work was to determine the methemoglobinemia and correlate with dapsone levels in multibacillary leprosy patients under leprosy multi-drug therapy. Thirty patients with laboratory and clinical diagnosis of multibacillary leprosy were enrolled. Dapsone was analyzed by high performance liquid chromatography and methemoglobinemia by spectrophotometry. The mean dapsone concentrations in male was 1.42 g/mL and in female was 2.42 g/mL. The mean methemoglobin levels in male was 3.09 µg/mL; 191%, and in female was 2.84 ± 1.67%. No correlations were seen between dapsone levels and methemoglobin in male and female patients. Our results demonstrated that the dosage of dapsone in leprosy treatment does not promote a significant methemoglobinemia.