Programa de Pós-Graduação em Doenças Tropicais - PPGDT/NMT
URI Permanente desta comunidadehttps://repositorio.ufpa.br/handle/2011/3558
O Programa de Pós-Graduação em Doenças Tropicais (PPGDT) integra o Núcleo de Medicina Tropical (NMT) da Universidade Federal do Pará (UFPA), realizando atividades de ensino, pesquisa e extensão e atuando na formação de docentes-pesquisadores para o estudo e o ensino das doenças tropicais e das patologias regionais no estado do Pará e na Amazônia.
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Tese Acesso aberto (Open Access) Fatores clínicos e laboratoriais da doença pelo HIV na composição corporal, força muscular, nível de atividade física, lipodistrofia e sua repercussão na qualidade de vida(Universidade Federal do Pará, 2014-11-28) SILVA, Luiz Fernando Gouvêa e; XAVIER, Marília Brasil; http://lattes.cnpq.br/0548879430701901The aim of this study was to analyze the association between clinical and laboratory factors of HIV disease on body composition, muscle strength, physical activity levels, the lipodystrophy syndrome and the influence of these factors on the quality of life of patients. The sample consisted of 219 HIV-infected patients, outpatients of the municipality of Santarem - PA. Sociodemographic information, clinical and laboratory profiles of the patients were collected as well as evaluations according to body composition, grip strength, physical activity levels, lipodystrophy and quality of life. Data were analyzed descriptively and inferentially, through the facilities of the software Graphpad Prism 3.0 and BioEstat 5.0, adopting a significance level of p <0.05. Sociodemographic results showed a higher frequency in males (59%), aged 28-37 years (35.2%), eight years of schooling or more (67.6%), parda ethnicity (73%), civil singleness (50.2%), income equal to or less than 2 minimum wages (76.8%), unemployed (17.1%). Clinically, most patients were on ART (89%) had a diagnosis of Aids (51.1%), diabetes was most frequent among the comorbidities (40%), tuberculosis between the co-infections (32.56%) and toxoplasmosis among other infections (51.43%), the most commonly used regimen was AZT/3TC/EFV (43.2%) and mixed lipodystrophy predominated (44.6%). It was observed that regimen AZT/3TC/LPV-r decreases muscle mass, arm muscle area (AMA) and dominant force in relation to the scheme consisting of AZT/3TC/EFV. Regarding associations, note that BMI was associated with the time of HIV infection, the percentage of fat related to gender and income, lipodystrophy with age, use of ART, time of infection and ART, the circumference of the abdomen (CAb) with gender, age, education, duration of infection and ART, the waist-hip ratio (WHR) with age, education and time to ART. For biochemical, immunological and hemoglobin markers was no association between BMI and glucose and triglyceride, percentage fat with total cholesterol and triglycerides, lipodystrophy with viral load, triglyceride and total cholesterol, the CAb with viral load, triglyceride and hemoglobin, WHR with glucose, triglyceride and total cholesterol. The AMA was higher in patients without IP in the ART regimen, with time of infection above 50 months and in males. The strength of the dominant and non-dominant handgrip were higher for males, not brown, not using IP in ART and normal concentration of hemoglobin. In addition, patients aged 60-68 years showed values of dominant and non-dominant force lower than other age groups. According to quality of life was observed lower scores for concern related to confidentiality and financial, were the largest ever with professional confidence and concern about medication. We can concluded that the presence of lipodystrophy, inadequate CAB and WHR caused changes in total cholesterol and triglyceride. Time of HIV and high ART positively associated with lipodystrophy, changed CAB and WHR. The active patients showed better scores for the overall function, life satisfaction, concerns about confidentiality and the overall average scores compared to inactive.Dissertação Acesso aberto (Open Access) Marcadores oxidantes e antioxidantes em populações expostas ao mercúrio em diferentes regiões geográficas do estado do Pará, Amazônia brasileira(Universidade Federal do Pará, 2014) OLIVEIRA, Claudia Simone Baltazar de; PINHEIRO, Maria da Conceição Nascimento; http://lattes.cnpq.br/6353829454533268This work has objective assess the levels of Hg-T, oxidative stress and antioxidants defenses in populations consumers of fish of different ecosystems from Amazônia. The communities selected for study are: Samaúma, Caratateua, and Barreiras all located in State of Pará. Participated 51 residents from Samaúma, 96 from Caratateua and 52 from Barreiras, of both sexes, between 13 and 55 years. Were collected samples of hair and blood during the visits in the communities for analysis of Hg-T and biochemistry oxidative and antioxidative in 2013. The dosage of GSHtotal, GSSG and GSH was performed in field. For quatification of TEAC and MDA, the samples were frozen and analyzed in the laboratory of oxidative stress of NMT. The analysis of Hg-T were performed in the laboratory of human toxicology and environmental of NMT.The Hg-T in Samaúma was 0.9 μg/g. Caratateua 1.9 μg/g , maximum 20.7 μg/g. Barreiras 4.6 μg/g and maximum 15.7 μg/g of Hg-T. In the dosage of Hg was noted difference statistics very sigficant between the communities. As for frequency of consume of fish, the levels of Hg-T from Caratateua and Barreiras were different statistically when compared to levels of Samaúma in the categories > 2 meals. The relationship between GSSG/GSH was larger in the community of Barreiras, 10. Caratateua and Barreiras presented levels of TEAC similar statistically 0,6 mm/L. In the dosage of MDA, Caratateua presented the larger levels, 3.1 ml/MDA, differing statistically the others comunidades. Only Barreiras community presented weak negative correlation between the levels of Hg-T and GSH. Concluded that The population from Samaúma and Barreiras presented smaller and larger degree of exposure to Hg respectively. However, 11% community of Caratateua presented levels above of recommended by OMS. Barreiras and Caratateua presented larger of degree of cellular oxidation. Thus, there is need for more studies in the community of Caratateua. Besides the application of educational measures in food, as: introduction of antioxidants, the choice of fish species and variability in the diet.