Artigos Científicos - ICEN
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Item Acesso aberto (Open Access) Avaliação do efeito antifúngico do óleo resina e do óleo essencial de copaíba (Copaifera multijuga Hayne)(2011) DEUS, Ricardo Jorge Amorim de; ALVES, Claudio Nahum; ARRUDA, Mara Silvia PinheiroCopaifera multijuga Hayne oil in natura and its fractions were evaluated as to their fungitoxic activities against five filamentous fungus species belonging to the genus Aspergillus and three yeast species of the genus Candida. Oleoresin and essential oil concentrations ranging from 0.08 mg mL-1 to 1.6 mg mL-1 were used for qualitative and quantitative analyses. The samples were placed onto 5mm-diameter paper discs distributed on Sabouraud's medium in Petri dishes inoculated with spores of the microorganisms and incubated at 28ºC for 10 days. A solution containing 1.6 mg mL-1 miconazole nitrate was used as positive control. Qualitative results showed that the oleoresin presented good activity, while a fraction of the essential oil was highly effective against Candida parapsilosis IOC-2882, Aspergillus flavus IOC-3874 and A tamarii IOC-187 with 16.0±1.4 mm, 19.5±2.1 mm and 12.5±3.5 mm inhibition halos, respectively. The quantitative evaluation showed that 0.3 mg mL-1 oleoresin inhibited the growth of Aspergillus flavus and Candida parapsilosis, while 0.08 mg mL-1 of the essential oil fraction reached this same activity.Item Acesso aberto (Open Access) A New Prenylisoflavone from the Antifungal Extract of Leaves of Vatairea guianensis Aubl.(Universidade Federal do Pará, 2017-06) SOUZA, Ronilson Freitas de; SILVA, Geilson Alcantara da; ARRUDA, Alberto Cardoso; SILVA, Milton Nascimento da; SANTOS, Alberdan Silva; GRISÓLIA, Daniella Paternostro de Araújo; SILVA, Moisés Batista da; ARRUDA, Mara Silvia PinheiroA new compound, 5,7,3'-trihydroxy-4'-methoxy-8-prenylisoflavone, was isolated from the leaves of Vatairea guianensis Aubl. (Fabaceae), together with two known isoflavones lupiwighteone and 5,7,4'-trihydroxy-3'-methoxy-8-prenylisoflavone. All isolated compounds were characterized based on infrared (IR), UV, 1H and 13C nuclear magnetic resonance (NMR), including 2D NMR analyses and high resolution mass spectrometry. The ethanolic extract from V. guianensis leaves displayed activity against Candida dubliniensis, C. albicans and C. krusei. However, the EtOAc fraction from that extract exhibited more significant activity than the ethanolic extract, showing antifungal activity for all fungi species investigated. The major compound 5,7,3'-trihydroxy-4'-methoxy-8-prenylisoflavone isolated from that EtOAc fraction was also active against C. parapsilosis and C. dubliniensis.