Navegando por Assunto "Antidepressivos"

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Acesso aberto (Open Access)
Avaliação do óleo essencial de pau-rosa (Aniba rosaeodora Ducke) em modelo de depressão induzida por álcool em ratas adolescentes
(Universidade Federal do Pará, 2023-08) SANTOS, Éverton Renan Quaresma dos; MAIA, José Guilherme Soares; http://lattes.cnpq.br/1034534634988402; MAIA, Cristiane do Socorro Ferraz; http://lattes.cnpq.br/4835820645258101
Depression is a prevalent disorder worldwide, which affects the functionality and quality of life of the people. The linalool-rich rosewood essential oil (Aniba rosaeodora Ducke) displays activities on the central nervous system (CNS), including of antidepressant-type. The work aimed to evaluate the effect of the essential oil in adolescent female rats through a model of binge drinking-induced depression. The essential oil was extracted by hydrodistillation and analyzed by a dual system of gas chromatography coupled to mass spectrometry (GC-MS) and gas chromatography with flame ionization detector (CG-FID). The in vitro antioxidant capacity of the essential oil was determined in the 1,1-diphenyl-2-picrylhydrazyl (DPPH•) radical scavenging assay. Female Wistar rats, 29 days old, received distilled water or ethanol (3 g/kg/day) orally in 4 binge episodes, and saline solution or rosewood oil (35 mg/kg) intranasally once a day for 28 days. After the experimental treatment, splash and forced swimming tests were performed. The brain-derived neurotrophic factor (BDNF) and S100B gene expression, biological parameters of the oxidative stress and levels of pro-inflammatory cytokines were determined in the prefrontal cortex and hippocampus. The OEPR+EtOH group increased self-cleaning time and decreased immobility time, both significantly compared to the EtOH group in the splash and forced swimming tests, respectively. The essential oil behavioral effects were related to positive modulation of BDNF and S100B genes, to restoration of glutathione (GSH) and Trolox equivalent antioxidant capacity (TEAC) levels, in addition to the attenuation of the increase of thiobarbituric acid reactive species (TBARS), Interleukin-1β (IL-1β), Interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) induced by alcohol. The results suggest that essential oil improved the alcohol-induced depressive profile through a neuroprotective mechanism by positively modulating the gene expression of neurotrophic factors, rebalancing the antioxidant status and attenuating the inflammatory process, possibly due to the linalool action.
Acesso aberto (Open Access)
Óleos essenciais ricos em linalol (Aniba Rosaeodora, A. Parviflora e Aeollanthus Suaveolens) na Amazônia e seus efeitos neurocomportamentais em roedores
(Universidade Federal do Pará, 2017-06-28) SANTOS, Everton Renan Quaresma dos; MAIA, Cristiane do Socorro Ferraz; http://lattes.cnpq.br/4835820645258101; MAIA, José Guilherme Soares; http://lattes.cnpq.br/1034534634988402
Essential oils from the Amazon, rich in linalool (Aniba rosaeodora Ducke, rosewood; A. parviflora (Meisn.) Mez, macacaporanga; and Aeollanthus suaveolens Mart. Ex Spreng, catinga-de-mulata), are capable of interacting with the central nervous system (CNS). The objective of this work was to evaluate the neurobehavioral effects of these oils in rodents. The oils were extracted and analyzed for their chemical composition, where the main constituent was linalool (rosewood, 88.6%; macacaporanga, 45%; and catinga-de-mulata, 49.3%). Linalool is an oxygenated monoterpene commonly found in various essential oils used in perfumes and fragrances. The Male Wistar rats received by intraperitoneal the oils of rosewood (doses of 3.5 and 35 mg/kg), macacaporanga (doses of 8.5 and 85 mg/kg), catinga-de-mulata (doses of 7, 5 and 75 mg/kg) and the linalool standard (30 mg/kg). The oils and linalool were administered 30 minutes prior to testing. Afterwards, the animals were evaluated in the open field tests, high cross labyrinth, splash, forced swimming and inhibitory avoidance. The results showed that rosewood, macacaporanga, and catinga-de-mulata oils (at the highest dose administered), as well as the standard linalool, have antidepressant-type activity. In the splash test, there was a significant reduction in latency to initiate self-cleaning behavior and the increase self-cleaning time, except for macacaporanga oil, in this last parameter. In the forced swim test, there was a significant reduction in the immobility time of the animals. The oils tested showed antidepressant activity due to the presence of linalool, without interfering with spontaneous locomotion and memory formation.