Navegando por Assunto "Anxiety"

Agora exibindo 1 - 3 de 3

Acesso aberto (Open Access)
Analise paramétrica do comportamento do zebrafish no labirinto em cruz com rampa
(Universidade Federal do Pará, 2020-03-20) MOTTA, Carla Mendes da; JUNIOR, Amauri Gouveia; http://lattes.cnpq.br/1417327467050274
Animal models have been a useful tool in the study and treatment of anxiety. Parametric studies are important to ensure these models validity since they help to identify witch parameters of the model are relevant to produce anxiety-like behaviors. The Plus-maze with Ramp is an anxiety model for fishes, adapted from the Elevated Plus-maze with Ramp. The present study consists of a parametric analysis of the zebrafish’s response in the Plus-Maze with Ramp, evaluating the effects of sex, ramp inclination, light level and arms width. Results showed that, regardless of any manipulation in the evaluated parameters, the animals preferred the flat arms instead of arms with ramp, that the light level of 700 lux increased the animal’s general exploratory behavior and that the ramp inclination of 34,43º increased the total number of entries in the flat arms. The plusmaze with Ramp seems to be a valid model for the study of anxiety in fish and the standard measures of the apparatus seems adequate.
Acesso aberto (Open Access)
Ansiedades: relatos e sentidos da experiência ansiosa
(Universidade Federal do Pará, 2024-08-30) ARAÚJO, Beatriz Evangelista de; SEIBT, Cezar Luis; http://lattes.cnpq.br/7464213317216078; https://orcid.org/0000-0003-0166-0919
Anxiety is a phenomenon inherent to the human experience, being a primary emotion that serves the function of self-preservation. Nowadays, anxiety has become increasingly prominent due to different relational demands that trigger intense emotional suffering, as well as exposure to stressors such as the proliferation of diseases, natural disasters, and/or those caused by human actions, etc. However, there is a predominance of viewing anxiety primarily through the hegemonic biomedical lens, categorizing it at a nosological level and conferring upon it the status of an "unbearable" illness. As a result, there is a perception that anxiety is something negative and must be cured/eliminated as quickly as possible. From this perspective, the subjective experience, the meanings attributed, the way the person recognizes themselves in this process, and even the historical and social context are disregarded, so the person is not understood in their complexity. In light of this, this research aimed to describe how people understand their own anxious experiences and to explore the outcomes resulting from different ways of experiencing and assigning meaning to anxiety. Additionally, it sought to expand the view of the anxious experience from the perspective of Laura Perls. To achieve these goals, we conducted qualitative-phenomenological research, in which Amedeo Giorgi's phenomenological method was applied, and the discussion was grounded in the phenomenological perspective and the Gestalt approach. During the identification of meaning units, nine constituents were identified, including: anxiety related to negative sensations, anxiety related to performance, anxious experiences affecting how one relates to others and the world, ambivalent feelings towards medication, and broadening the understanding of anxiety. We concluded that the research objectives were met, supporting the understanding that the anxious experience can manifest in different ways, considering that anxiety is configured as a relational phenomenon, manifesting as a response to environmental demands. Therefore, it is necessary to pay attention to the complexity of situations that make up the human experience. In this sense, we emphasize the relevance of considering the intersectional dimensions that permeate a person's experience and modify their way of perceiving themselves and relating to the world. Furthermore, it was possible to deepen some concepts of the Gestalt approach from Laura Perls' point of view, also highlighting her importance for the consolidation of Gestalt therapy, despite having written few materials, and also having undergone a process of invisibilization within the approach.
Acesso aberto (Open Access)
Validação farmacológica da esquiva Inibitória do Danio Rerio
(Universidade Federal do Pará, 2013-06-12) SANTOS, Bruno Rodrigues; GOUVEIA JUNIOR, Amauri; http://lattes.cnpq.br/1417327467050274
The Danio rerio is a fish species widely used in emerging models of anxiety due to well described behavior, anatomy, neuroanatomy and biochemistry. The inhibitory avoidance test is an anxiety-related parameters in the model development that described a suppressed behavior emitted to avoid an aversive stimulus. This experiment aimed to describe the inhibitory avoidance averssiveness of white side and the pharmacological validation of this test by using the following drugs: antidepressants - fluoxetine (5, 10 and 20 mg/kg) and imipramine (4, 8 and 16 mg/kg), anxiolytics - diazepam (0.06, 1.25 and 2 , 5 mg/kg) and clonazepam (0.02, 0.05 and 1.10 mg/kg), and stimulants - diethylpropion (2.5, 5 and 10 mg/kg) and caffeine (10, 20 and 40 mg/kg). The data confirm the aversiveness of the white side in inhibitory avoidance test. Flouxetine, imipramine, caffeine and dietilpropione have anxiogenic-like effect and imapaired inhibitory avoidance, excluding imipramine 8 mg/kg who facilitates its acquisition. Diazepam also facilitates inhibitory avoidance acquisition and clonazepam show anxiolytic-like effect on this test. These data show the effectiveness of inhibitory avoidance test as a model to study axiety.