Navegando por Assunto "Artrite reumatóide"

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Acesso aberto (Open Access)
Formation of multiple pulmonary nodules during treatment with leflunomide
(2015-06) YOSHIKAWA, Gilberto Toshikawa; DIAS, George Alberto da Silva; FUJIHARA, Satomi; SILVA, Luigi Ferreira e; CRUZ, Lorena de Britto Pereira; FUZII, Hellen Thais; KOYAMA, Roberta Vilela Lopes
Pulmonary involvement is one of the extra-articular manifestations of rheumatoid arthritis and can be due to the disease itself or secondary to the medications used in order to treat it. We report the case of a 60-year-old woman who had been diagnosed with rheumatoid arthritis and developed multiple pulmonary nodules during treatment with leflunomide.
Acesso aberto (Open Access)
Incidence of tuberculosis among patients with rheumatoid arthritis using TNF blockers in Brazil: data from the Brazilian Registry of Biological Therapies in Rheumatic Diseases (Registro Brasileiro de Monitoração de Terapias Biológicas – BiobadaBrasil)
(Universidade Federal do Pará, 2017) YONEKURA, Claudia Leiko Yonekura; OLIVEIRA, Renê Donizeti Ribeiro de; RANZA, Roberto; RANZOLIN, Aline; HAYATA, André Luiz Shinji; SILVEIRA, Inês Guimarães da; CARVALHO, Hellen Mary da Silveira de; MORAES, Julio Cesar Bertacini de; ABREU, Mirhelen Mendes de; VALIM, Valéria; BIANCHI, Washington Alves; BRENOL, Claiton Viegas; PEREIRA, Ivânio Alves; COSTA, Izaias Pereira da; MACIEIRA, José Caetano; GUEDES-BARBOSA, Luiz Sérgio; BERTOLO, Manoel Barros; CUNHA, Maria de Fátima Lobato da; SILVA, Marília Barreto Gameiro; FREIRE, Marlene; SCHEINBERG, Morton Aaron; TOLEDO, Roberto Acayaba de; OLIVEIRA, Sheila Knupp Feitosa de; FERNANDES, Vander; PINHEIRO, Marcelo de Medeiros; CASTRO, Gláucio Ricardo Werner de; VIEIRA, Walber Pinto; BAAKLINI, Cesar Emile; RUFFINO-NETTO, Antonio; PINHEIRO, Geraldo da Rocha Castelar; LAURINDO, Ieda Maria Magalhães; LOUZADA-JUNIOR, Paulo; TITTON, David C.; DUARTE, Angela; MIRANDA, Jose R. S.
Objectives: To assess the incidence of tuberculosis and to screen for latent tuberculosis infection among Brazilians with rheumatoid arthritis using biologics in clinical practice. Patients and methods: This cohort study used data from the Brazilian Registry of Biological Therapies in Rheumatic Diseases (Registro Brasileiro de Monitoração de Terapias Biológicas - BiobadaBrasil), from 01/2009 to 05/2013, encompassing 1552 treatments, including 415 with only synthetic disease-modifying anti-rheumatic drugs, 942 synthetic DMARDs combined with anti-tumor necrosis factor (etanercept, infliximab, adalimumab) and 195 synthetic DMARDs combined with other biologics (abatacept, rituximab and tocilizumab). The occurrence of tuberculosis and the drug exposure time were assessed, and screening for tuberculosis was performed. Statistical analysis: Unpaired t-test and Fisher's two-tailed test; p < 0.05. Results: The exposure times were 981 patient-years in the controls, 1744 patient-years in the anti-TNF group (adalimumab = 676, infliximab = 547 and etanercept = 521 patient-years) and 336 patient-years in the other biologics group. The incidence rates of tuberculosis were 1.01/1000 patient-years in the controls and 2.87 patient-years among anti-TNF users (adalimumab = 4.43/1000 patient-years; etanercept = 1.92/1000 patient-years and infliximab = 1.82/1000 patient-years). No cases of tuberculosis occurred in the other biologics group. The mean drug exposure time until the occurrence of tuberculosis was 27(11) months for the anti-TNF group. Conclusions: The incidence of tuberculosis was higher among users of synthetic DMARDs and anti-TNF than among users of synthetic DMARDs and synthetic DMARDs and non-anti-TNF biologics and also occurred later, suggesting infection during treatment and no screening failure.