Navegando por Assunto "Boca"

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Características epidemiológicas relativas à doença dental e infecção por Helicobacter pylori na cavidade oral de estudantes em Belém-Pará
(Universidade Federal do Pará, 2009) MATOS, Gyselly de Cássia Bastos de; CORVELO, Tereza Cristina de Oliveira; http://lattes.cnpq.br/7253864056606024
The infection by Helicobacter pylori is one of the most common in humans and despite having tropism by stomach, can be found in the oral cavity, maintaining a commensal relationship with the host, while dental caries is also an infectious disease and results from the metabolism of the bacterial plaque. Both infections are highly prevalent in developing countries, since these populations are more exposed to environmental risk factors, and are usually acquired during childhood. The prevalence of these infections was investigated in the oral cavity of school children with no symptoms of gastric diseases, from a population of Belém-Pa, in relation to some parameters of oral hygiene and health, socioeconomic conditions and genetic susceptibility factors like the ABO and Lewis blood groups. Were investigated 104 patients, with average age of 17 years. Of all the participants were collected saliva samples and dental plaque. Saliva was collected to identify the ABO and Lewis state secretor and estimation of salivary parameters, and both, saliva and plaque samples were collected for molecular analysis of 16S rRNA genes of H. pylori and FUT2. H. pylori was detected in 79.8% of the students, with a frequency of 66.35% in dental plaque and 58.65% in saliva. The caries prevalence was 82.8% in the population studied. The clinical evaluation of oral health showed that the average CPO-D found was 3.53. It was observed that the caries experience tends to increase as in addition to age and the H. pylori infection was higher in early childhood. The education level and number of dentist visits showed significant differences in relation to the presence of H. pylori. The phenotypic distribution of ABO and Lewis blood groups did not differ significantly between infected and uninfected individuals, explaining there is greater genetic susceptibility to infection by H. pylori and dental caries. Throughout this analysis, the high frequencies found prove the need for care and treatment of dental diseases, such as caries and it is suggested that H. pylori in the oral cavity can contribute to infection and re-infection of the stomach after treatment.
Acesso aberto (Open Access)
Imunoexpressão da proteína PTEN em amostras de carcinoma epidermoide bucal e sua correlação com características clínico-patológicas e sobrevida
(Universidade Federal do Pará, 2016-06-03) KATO, Valdenira de Jesus Oliveira; PONTES, Hélder Antônio Rebelo; http://lattes.cnpq.br/8076555757131891; BURBANO, Rommel Mario Rodriguéz; http://lattes.cnpq.br/4362051219348099
Oral Squamous Cell Carcinoma (OSCC) is the most common malignant neoplastic that affects the oral cavity, accounting for 90% of all cases diagnosed in this anatomic site. Despite the recent advances in the treatment, the survival rate varies from 30 to 50%. Molecular mechanisms which elucidates the agressive behaviour of these lesions help to identify new chemotherapeutics that might be used in the treatment in order to improve the survival rates. The aim of this study was investigating the imunoexpression of PTEN protein through the immunohistochemical technique (IHC) in CEB samples and relate them with clinicopathological features, histological grades and survival and in addition, evaluate the presence of allelic deletion through the Fluorescent In Situ Hybridization technique (FISH). Our results showed that a total from 119 cases of CEB, 31 cases were negative to expression of protein PTEN and 88 cases were positive for PTEN, from which 15 (17,05%) were well differentiated, 43 (48,86%) moderately differentiated and 30 (34,09%) were poorly differentiated. Considering the clinicophatological features, there were not statistically significant correlations with the IHC expression of PTEN. Regarding the survival rates, it was observed that patients presenting lymph node infiltration (N) = 2 or 3 has 4 times greater risk of dying than those presenting N = 0 or 1. Finally, there was a significant association between expression by IHC negative and the result of FISH technique regarding the deletion, and between the positive PTEN expression and the non-deleted result of FISH technique.