Navegando por Assunto "Cancer"

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Desconhecido
Experiências de familiares cuidadores de pacientes oncológicos em cuidados paliativos à luz da teoria de Meleis
(Universidade Federal do Pará, 2022-08-09) GOMES, Ana Carolina de Sousa; SANTANA, Mary Elizabeth de; http://lattes.cnpq.br/6616236152960399; https://orcid.org/0000-0002-3629-8932
Cancer is considered the second leading cause of death in the Region of the Americas, being diagnosed in the year 2020, four million new cases and about 1.4 million deaths due to the disease. At a global level, one in six deaths are related to cancer, highlighting the need for investments in health promotion and in the search for changing the patterns of exposure to risk factors. The diagnosis of the disease mobilizes in patients and their families positive and negative feelings that need to be understood by health professionals. Therefore, families are included in the care process, as a way of adapting them to situations related to illness and terminality, so that they can also provide adequate support to their patients. At this moment, family members experience a transition to a new role, as a family caregiver. In view of such considerations, and the relevance of this theme in the field of Nursing, Afaf Ibrahim Meleis' Theory of Transitions was selected as the theoretical basis for the present study. The general objective is to analyze the experiences of family caregivers of cancer patients in palliative care, in the light of Afaf Meleis' theory of transitions. And as specific objectives: to understand the transition experiences of the family member of patients in oncological palliative care when exercising the role of caregiver; to describe the facilitating and inhibiting factors of transition in the process of caring for cancer patients; to know how family caregivers experience grief and its phases during the process of caring for a patient in oncological palliative care. This is a descriptive study with a qualitative approach. Held at the Palliative Care Clinic (CCPO) 1 and 2 of the Ophir Loyola Hospital (HOL), in the period of June 2022. Participated in the study 15 family caregivers of cancer patients undergoing treatment at these held, aged over 18 years, with ties of kinship, affection and/or friendship with the patient, in physical, emotional, and psychological conditions to answer the questions in the interview script, and who voluntarily agreed to participate in the study after reading and signing the Free and Informed Consent Term. Data analysis was carried out using Braun and Clarke's Thematic Analysis (TA), a qualitative analysis technique composed of six phases. Thus, three major themes emerged, which were analyzed and discussed based on the model of Meleis' Transitions Theory: the transition of roles, the facilitating and inhibiting factors of the transition to the care process and the stages of mourning and religiosity in the death process and die. Such categories show a situational transition given the acquisition of a new role, identifying the properties of awareness, engagement and change, with the acquisition of skills and attitudes towards the illness of a loved one, permeated by nursing therapies and the multidisciplinary team in the context of the palliative care, the results reflect that not all family caregivers experienced a healthy transition. From the results, it was possible to understand the experiences of family caregivers of cancer patients in palliative care, and the importance of nursing interventions in the process of death and dying, thus promoting a healthy transition in the context of care.
Desconhecido
Planejamento, síntese e aplicações de derivados naftosalicílicos como antioxidantes
(Universidade Federal do Pará, 2017-08-30) BARROS, Valéria Araújo; BORGES, Rosivaldo dos Santos; http://lattes.cnpq.br/4783661132100859; https://orcid.org/ 0000-0003-4072-7573
Salicylate derivatives are successfully applied as analgesics, antipyretics, anti-inflammatories and in cancer prevention, especially rectal colon. They reduce the risks of many diseases associated with elderly. However, adverse effects related to gastrointestinal events are always associated to its main constituent acetylsalicylic acid. These aspects are linked to their chemical stability and affinity for some biological receptors. The aims of this work are the design, synthesis and applications of naphthalene-salicylic derivatives as antioxidants. Thus, a theoretical study of the studied compounds was carried out. Calculations of electronic properties such as frontier orbitals HOMO-LUMO, ionization potential (IP), bond dissociation energy of phenolic moiety (BDEOH), and spin density contributions were performed by using density functional theory (DFT) at the B3LYP/6-31G (d, p) level of theory on Gaussview and Gaussian computational packages. Some of these compounds were synthesized by using classical methods. The theoretical results showed that both additional hydroxyl or substitution on benzene ring for naphthalene increase the antioxidant capacity in the same values with small dissimilarities among acid, ester, and amide derivatives. A synergistic effect was observed when both are used together, producing the most potent molecules. In addition, spin density calculations indicated a regioselective pathway can be gotten from monohydroxylic derivatives, with high possibility of in vivo generating of dihydroxy derivatives mainly at the para position relative to the phenolic group, through enzymatic or non-enzymatic reactions. Finally, the replacement of the naphthalene ring instead of the benzene ring increases both reactivity and chemical stability for the quinone-type intermediates, explaining how these compounds will play a role in the preventive mechanisms and way treatment of cancer. Anti cancer and anti-inflammatory activities are being performed for some of the synthesized compounds.
Desconhecido
Representações sociais de enfermeiros sobre a espiritualidade na assistência a pacientes oncológicos
(Universidade Federal do Pará, 2022-08-01) GOMES, Lucas Vinicios Sodré; SILVA, Sílvio Éder Dias da; http://lattes.cnpq.br/0084512862619143; https://orcid.org/0000-0003-3848-0348
Introduction: The relationship between spirituality and religiosity is always the subject of long discussions, both in the academic environment and in the social context among the community in general. However, it is known that spirituality harbors experiences of a universal nature, cultural and intimate values of a certain group of individuals, while religiosity is linked to doctrine, relationships with the supernatural and with the sacred. Therefore, the relationship between spirituality and nursing is linked to integrality during hospital care and, in this way, is shown to be positive and associated with a predisposition to improve the clinical condition when feelings such as: anguish, fear and questions about life are experienced. is the death. The social representations made it possible to familiarize the social phenomenon of spirituality in a hospital environment and in the context of nursing. Objective: This work aims to understand the social representations of nurses about spirituality and its implications for the nursing care provided to cancer patients. Method: It is a descriptive study, with a qualitative approach and that uses the bases of the Theory of Social Representations (TRS). Results: The procedural aspect of the French school of social psychology, defended by Serge Moscovici and Denise Jodelet and collaborators, was used. The understanding of social representations about nurses' spirituality in patients was presented through the technique of free association of words and the thematic analysis of Braun & Clark. Final Considerations: It was soon possible to understand the social representations and the nurses' experiences about the psycho-spiritual needs and the implications for nursing since it is linked to the changes in this process in oncological patients.