Navegando por Assunto "Cetoconazol"

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Acesso aberto (Open Access)
Obtenção e caracterização de carreadores lipídicos nanoestruturados a partir de gordura vegetal de murumuru (Astrocaryum murumuru Mart.)
(Universidade Federal do Pará, 2016-05-16) SENA, Luann Wendel Pereira de; SILVA JÚNIOR, José Otávio Carréra; http://lattes.cnpq.br/4437885351749994
The nanostructured lipid carrier (NLC) have been proposed as a carrier’s category for pharmaceutical and cosmetic ingredients and an increasing of interest due to a series of advantages when compared to conventional formulations. The Amazonian vegetable fats are considered lipids arrays of great potential for the production of NLC from topical administration, according to the low toxicity and biocompatibility, beyond their emollient properties, protector and moisturizer in the skin. The murumuru (Astrocaryum murumuru Mart.) is an amazon palm and the utility of its fat is promising, because it adds value to the products, favour the growth in the region, in addition to using these resources in a sustainable way. The objective of this research was to obtain and characterize the NLC from the vegetable fat of Murumuru (Astrocaryum murumuru Mart.) by the homogenization technique under high pressure to hot, using ketoconazole as a drug modelling. The gas chromatography showed lauric acid (48,1 %), myristic acid (26,6 %) and oleic acid (8,4 %), as main constituents. The physical-chemical characterization showed acid, iodine, saponification, peroxide, refraction and density values within the limits and standards recommended. The isolated raw materials and the NLC obtained were evaluated using differential scanning calorimetry, where the results about the isolated raw materials used support as was described in Literature and the NLC demonstrated a crystalline structure less ordained. In the tested formulations, the nanoparticles showed average size between 98,60 and 161,56 nm, polydispersibility index between 0,115 and 0,276, zeta potential higher than -30mV and encapsulation efficiency near 100 %. The Transmission Electron Microscopy indicated spherical aspect of the nanoparticles and the! clearance profile showed a zero order kinetic model, with the release of 70,9 % of the encapsulated drug in 8 hours. The nanoparticles remained stable during a period of 60 days. This research showed that the murumuru fat obtained an effective system, with small sizes particles and penetrability in the skin, making possible the formulation propagation in pharmaceutical and cosmetic uses.
Acesso aberto (Open Access)
Obtenção e caracterização de nanoemulsão óleo em água a partir de óleo de açaí (Euterpe oleracea M.)
(Universidade Federal do Pará, 2015-05-13) CONTENTE, Denise Maria Loureiro; SILVA JÚNIOR, José Otávio Carréra; http://lattes.cnpq.br/4437885351749994
Nanoemulsions have been proposed as an option for drug delivery current systems and increasing interest due to several advantages when compared with traditional formulations. Vegetable oils are considered pharmaceutical ingredients of great value as lipid matrix of these systems, such as oil açaí, of Amazonian origin oil, which has a number of medicinal benefits such as antioxidant and moisturizing activity, and biocompatibility, increases skin elasticity and acts as a physical barrier. The objective of this study was to obtain nanoemulsion O / W, from açaí oil, surfactant and water, through the phase inversion temperature method for topical use. Açaí oil was characterized by physical-chemical tests and on the profile of fatty acids by gas chromatography (GC), spectrometry in the infrared (FT-IR) and thermal analysis by thermogravimetry (TG) and differential scanning calorimetry (DSC). The surfactant, ketoconazole and their binary mixtures with oil açaí were evaluated by DSC. Obtained nanoemulsions making use of açaí oil, BrijTM CS20, water and ketoconazole. The characterization of nanoemulsions was performed on the droplet size, polydispersity index (PI), the zeta potential (PZ), morphology and encapsulation efficiency (EE). The açaí oil showed acid value (3.78 mg KOH / g), iodine value (71 gl2 / 100g), saponification number (199 mg KOH / g), refractive index (1.470) and density (0,950g / ml). In GC analysis showed 68.05% of unsaturated fatty acids, being 47.58% oleic acid. Oxidative stability of açaí oil Rancimat was about 11.79 hours. The FT-IR spectrometric analysis confirmed bands suggestive of unsaturated fatty acids and thermal analysis it was observed that the thermal degradation occurs above 200 ° C. The combinations of raw materials analyzed by DSC was observed that the incorporation of ketoconazole with açaí oil. The nanoemulsion B10 with 0.5% ketoconazole showed 98.31% EE. The transmission electron microscopy showed droplets with spherical shape and after study of PZ (-25.53 ± 10.04 mV), PI (0.37 ± 0.04) and size (128.53 nm ± 10.04) by 30 days, nanoemulsion showed little variation. Thus, it can be said that açaí oil has the potential to be used as a pharmaceutical ingredient can be used as oil phase nanoemulsions loaders of fat-soluble substances.