Navegando por Assunto "Comportamento motor"

Agora exibindo 1 - 3 de 3

Acesso aberto (Open Access)
Avaliação das alterações cerebelares decorrentes da exposição ao etanol da adolescência à fase adulta
(Universidade Federal do Pará, 2014-05-07) CUNHA, Polyane Alencar; LIMA, Rafael Rodrigues; http://lattes.cnpq.br/3512648574555468; MAIA, Cristiane do Socorro Ferraz; http://lattes.cnpq.br/4835820645258101
Alcohol abuse has reached massive proportions, associated with a number of adverse consequences, becoming one of the most widespread phenomena of recent decades and therefore alcohol, alcoholic disease agent of a public health problem. Young people are under physiological and social transition, with the curiosity, the pressure of the social group, the family model, propaganda and lack of public policies, the main risk factors which lead to early alcohol consumption. The teenager once is maturing presents its central nervous system (CNS) vulnerable to aggression caused by the consumption of this drug. It is known that alcohol promotes a series of motor change the point of view of clinical and physiological concurrently. These amendments are consequential action of alcohol sore CNS, specifically on the Cerebellum, and by chronic use of the drug suffer (like other organs of the CNS) some changes. The aim of this study was to evaluate the cerebellar changes resulting from exposure to ethanol from adolescence to adulthood in rats, on the morphometric patterns observed in the organ, tissue response and investigation of oxidative balance the body against the injury caused by toxic. Mice received from the 35th day of postnatal life (puberty period) by gavage at a dose of EtOH 6.5g/kg/day for 90 days (adulthood). To view the injury caused to the fabric was made morphometric biochemical research and analysis through oxidative stress. The results show that cerebellar mass is not changed, but there is a reduction in organ size and an increase in the density of the cell population in the molecular and granular layers, however a decrease in neuronal cells, with all the changes occurred were not morphohistologics accompanied by alterations in the biochemical oxidation.
Acesso aberto (Open Access)
Caracterização da injúria no córtex motor de ratos em um modelo de exposição crônica ao metilmercúrio (MeHg)
(Universidade Federal do Pará, 2016-12-21) SANTANA, Luana de Nazaré da Silva; LIMA, Rafael Rodrigues; http://lattes.cnpq.br/3512648574555468
The mercury is an environmental contaminant which poses a great risk to human health. Exposure to this toxic metal occurs mainly through a diet contaminated by methylmercury (MeHg) in low concentrations and over a long period of time. Thus, in this study we propose an assessment of the effects of MeHg on the motor cortex in an animal model of chronic exposure and low dose, similar to dietary exposure in areas of high environmental toxicity of mercury. Adult rats were exposed to MeHg for 60 days with a dose of 0.04 mg/kg/day, while the control group received only the vehicle. After this period, they were subjected to behavioral testing in order to evaluate the motor performance after mercury exposure, and then sacrificed and evaluated for oxidative biochemical parameters (change in the concentration of nitrite - NO Lipid Peroxidation - LPO and Antioxidant Capacity Total) as well as evaluation of total deposits of mercury in the motor cortex and changes in cell density of neurons and astrocytes. Data were tabulated and statistically analyzed by Student's t-test (p <0.05). It was possible to observe total mercury deposits in the motor cortex, and deficits in motor parameters, with a reduction in the overall locomotion, on balance and increase in the number of failure, coupled with a significant increase in the levels of NO and LPO and decreased ability antioxidant full of animals exposed, reducing the population of astrocytes and neurons compared to control animals these findings suggest that exposure of adult animals to MeHg, even at low dose and chronically, causes changes in the motor cortex with damage to their functions.
Acesso aberto (Open Access)
Efeitos no comportamento motor após intoxicação subcrônica de metilmercúrio na presença de etanol (padrão binge) em ratas adolescentes à fase adulta
(Universidade Federal do Pará, 2015-11-06) OLIVEIRA, Aline do Nascimento de; MAIA, Cristiane do Socorro Ferraz; http://lattes.cnpq.br/4835820645258101
Exposure to methylmercury through the contaminated seafood diet, concomitant abusive alcohol intake, in binge pattern, is quite common in gold mining communities of gold extraction, especially in the Amazon. The association between these two neurotoxicantes is also evident among adolescent women and creates the need to understand its effects on the central nervous system, especially in motor coordination, balance and spontaneous locomotion, because the studies are advanced only for the effects of exposure in isolation. Therefore this study aims to evaluate the effects on motor behavior resulting of subchronic exposure to methylmercury in the presence of alcohol, in binge pattern, in adolescents female rats until early adulthood (37-72 postnatal day), through behavioral motors tests, like Open Field, Pole Test, Rotarod and Beam Walking Test. The testing occurred 24 hours after the last intoxication of rats, which received methylmercury (0.04 mg / kg / day) for 35 days, concomitant with alcohol (3g / kg / day), 3 intermittent days, 1 time per week (binge), totaling 5 binges. The results showed a decrease in spontaneous locomotion in Open Field test through the parameters of the total distance traveled and number of rearing. In the Pole test was increased fall time, evidencing the bradykinesia. In the Rotarod there was a decrease in latency in the first three exhibitions, as well as Beam Walking Test was increased latency and number of slips, especially in thinner beams, showing that subchronic exposure to methylmercury in the presence of alcohol, in the binge, in adolescent female rats was able to produce behavioral damages related to coordinating motor, balance and spontaneous locomotor activity.