Navegando por Assunto "Criptococose"

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Caracterização epidemiológica, genotípica e fenotípica da criptococose em uma unidade de referência no estado do Pará
(Universidade Federal do Pará, 2012) FURTADO, Karen Cristini Yumi Ogawa; ISHIKAWA, Edna Aoba Yassui; http://lattes.cnpq.br/3074963539505872; SOUSA, Rita Catarina Medeiros; http://lattes.cnpq.br/3560941703812539
Cryptococcosis is a fungal infection caused by an encapsulated yeast Cryptococcus genus that affects both humans and animals, and is considered as an opportunistic infection commonly associated with immunosuppression. This is one of human fungal infections cause significant morbidity and mortality in both immunocompetent and in immunocompromised individuals and appears mainly in the form of meningoencephalitis. The aim of this study was to characterize epidemiological, genotypic and phenotypic cryptococcosis in a reference unit in the state of Pará. The target population was composed of patients treated at the University Hospital João de Barros Barreto/UFPA, January 2010 to December 2011 with laboratory confirmed diagnosis of cryptococcosis. Personal, clinical and laboratory data were collected from a review of medical records file HUJBB and the isolates were identified and characterized morphologically and biochemically. The type sexed and genotype were identified by PCR using specific primers. From January 2010 to December 2011 were identified 59 cases of cryptococcosis. Most patients were men (36/59, 61%), aged 5-70 years, mean 30.8 years. The predominant age group was 34-43 years (39% of cases). The main signs and symptoms presented by them were headache (85.5%), vomiting (80%) and fever (76.4%). All children (6/6) were HIV negative, and as the causative agent C. gattii (31.6%), while in adults 71.1% of infections were caused by C. neoformans, most HIV positive. The cases of death and recurrence were higher among patients infected with C. neoformans and the presence of sequelae was more frequent among patients infected with C. gattii. All isolates were MAT α and there was a predominance of two molecular types: VNI (64.4%) and VGII (35.6%). This study reinforces that the state of Pará is endemic to infection by Cryptococcus spp., Whose main clinical presentation, meningoencephalitis determines high rates of morbidity and mortality.
Acesso aberto (Open Access)
Criptococose em crianças no Estado do Pará, Brasil
(1999-10) CORRÊA, Maria do Perpétuo Socorro Costa; OLIVEIRA, Eliseth Costa; DUARTE, Rosineide Roseli Barros Seixas; PARDAL, Pedro Pereira de Oliveira; OLIVEIRA, Flávio de Mattos; SEVERO, Luiz Carlos
Relatam-se 19 casos de criptococose em crianças, diagnosticados em Belém, PA. Em nove pacientes a variedade do agente etiológico foi estudada e identificada como Cryptococcus neoformans var. gattii. A média de idade destes pacients foi 7,8 anos (variação, 5-13 anos). Havia 5 meninas e 4 meninos (razão, 1,25:1). Cinco foram a óbito em três meses apesar do tratamento com anfotericina B (associada com fluconazol 3 ou fluocitosina 1). São comentados a existência de áreas de alta endemia da infecção por var. gattii no Pará e a gravidade da doença causada por essa variedade fúngica.
Acesso aberto (Open Access)
Fatores prognósticos de letalidade na meningoencefalite criptocócica em crianças e adolescentes no estado do Pará
(Universidade Federal do Pará, 2016) CARNEIRO, Rose Sheyla Rodrigues; SOUSA, Rita Catarina Medeiros; http://lattes.cnpq.br/3560941703812539; RODRIGUES, Anderson Raiol; http://lattes.cnpq.br/4030747999301402
Introduction: Cryptococcosis is a systemic fungal infection that often affects adults, especially those who have an alteration in their cellular immunity. Its frequency in children is low. Objective: to describe the clinical, epidemiological, radiological and laboratorial profile of children with meningitis cryptococcal, and to evaluate what are the circumstances that affect the evolution of these patients and increase the fatality rates of the disease. Materials and methods: we performed a retrospective review of medical records in which we evaluated the prognostic factors of 62 children less than 16 years old, diagnosed with cryptococcal meningoencephalitis, admitted in the at João de Barros Barreto Hospital, reference for patients with infectious diseases in Belém-PA, from 1999-2013. Results: Ages ranged from less than 4 to 15 years. The average age was 10 and 66% were male. The Para state microregions, presented by order of decreasing frequency, showed: Cametá (29%), Guamá (12,9%), Belém (12,9%), Tomé-Açu (11,3%), Bragantina (9,7%) and others (39%). The predominant clinical presentation was the subacute form, represented by 50% of the cases. The most frequent clinical manifestations were headache (98,4%), fever (91,9%) and vomiting (88,7%). A skull tomography was performed in 54 patients, and abnormalities were reported in 43 (79,6%). Hydrocephalus was described in 27 cases. Cryptococcus gattii was the main agent involved, identified in 35 children (71,4%). In total, 91,9% of the patients were treated with amphotecicin B (AmB) alone. Conclusions: Rate of lethality from 19,3%; Seizure was a prognostic factor of lethality. In the State of Pará, where cryptococcosis by Cryptococcus gattii is endemic, the disease in children is relatively frequent. However, studies in this population are still scarce and there are no own management guides. New studies are needed to improve the management of children by this fungal infection.
Acesso aberto (Open Access)
Perfil clínico-epidemiológico da Criptococose em pacientes HIV positivos atendidos em uma unidade de referência em Belém do Pará
(Universidade Federal do Pará, 2012) ALMEIDA, Jairo Cunha de; SOUSA, Rita Catarina Medeiros; http://lattes.cnpq.br/3560941703812539
Cryptococcosis among residents of the state of Pará presents as severe endemic disease, occurring in different mesoregions state end the metropolitan area of Belém occurscausing cryptococcal meningitis, with a mortality rate above 40%. To try to elucidate the clinical end epidemiological study of cryptococcosis in HIV-positive patients, we conducted a retrospective study, analytical case series with chart review of the last 05 year (2006 – 2010), with HIV-positive patients in a referral hospital in Belém- Pará. The disease is still one of the most frequent causes of death in HIV-positive patients in our region and due to C. neoformans the largest number of cases, accouting for 57 (60,6%) ot a total of 94 cases. Regarding the clinical form of cryptococcosis, developed by the HIV-positive patients, we observed that the nervous system is present in 46,8% of patients and the spred of disease in 27,7% of cases. The relationship between the cause of deathand the presence of Cryptococcus occurs by a complex set of factors that must be clarified and correlated with patient death end most importantly, establisn qua strong in this relationship once detected.