Navegando por Assunto "Crotton pullei"

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Acesso aberto (Open Access)
Avaliação in vitro dos possíveis efeitos citotóxicos e genotóxicos do alcalóide julocrotina em linfócitos humanos
(Universidade Federal do Pará, 2011-11-04) CORREA, Regianne Maciel dos Santos; BAHIA, Marcelo de Oliveira; http://lattes.cnpq.br/3219037174956649
Leishmaniasis is considered a public health problem, mainly due to the presence of different species of enzootic Leishmania, involving many different hosts and insect vectors. The pentavalent antimony remain the first choice drugs for the treatment of leishmaniasis for more than 50 years, however, its use has been compromised due mainly to the parasite developed resistance to the drug. Thus, the choice of drugs derived from plants based on the study and use of traditional medicine practices should appear as a new strategy for the control of leishmaniasis. However, it is important to note that some of these drugs can be toxic to the body and may even have genotoxic properties, causing changes in DNA with consequent increased risk of carcinogenesis. Julocrotine (2 -[N-(2-methylbutanolyl)]-N-phenylethylglutarimide) is an alkaloid isolated from the species Croton pullei var. glabrior Lanj. (Euphorbiaceae), widely found in the Amazon jungle and known to possess potent leishmanicidal effect. Thus, the present study evaluated the cytotoxic and genotoxic effects of julocrotina using the MTT and the Comet Assays in cultured human lymphocytes. Our results showed that the alkaloid did not show cytotoxicity in human lymphocytes at the concentrations tested. However, julocrotine showed to be genotoxic to human lymphocytes treated with the highest concentration (632μM) of the substance. Although the cytotoxicity results seem promising with respect to the use of julocrotina in the treatment of leishmaniasis, the genotoxic effect observed reinforces the need to obtain the necessary cautions for its use as an herbal leishmanicidal.
Acesso aberto (Open Access)
Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae)
(2008-09) ROCHA, Fabio Fagundes da; NEVES, Evandro Manoel Neto; COSTA, Elson Alves; MATOS, Lécia Garcia de; MÜLLER, Adolfo Henrique; GUILHON, Giselle Maria Skelding Pinheiro; CORTES, Wellington da Silva; VANDERLINDE, Frederico Argollo
Croton pullei var. glabrior Lanj. (Euphorbiaceae) is a liana, vastly distributed in the Amazonian Forest. In the folk medicine, several plants of the Croton genus have been used with therapeutic purposes in pathologies that involve painful and inflammatory diseases which justify this work. The aim of this study was to investigate the antinociceptive and antiinflammatory activities of the C. pullei leaves methanol extract (MECP). MECP reduced in a dose-dependent manner the number of acetic acid-induced abdominal writhing (1.2%) in mice, suggesting an antinociceptive activity of the plant. On the other hand, MECP did not significantly modify the reactivity to the thermal stimulation in the hot-plate test and the reactivity to the chemical stimulation in the formalin test first phase, indicating a non-opioid mechanism. MECP reduced the formalin-induced nociception in the second phase, inhibited the croton oil-induced ear edema and reduced the leukocytes migration in the test of the carrageenan-induced peritonitis, indicating an antiinflammatory activity. Although the mechanisms that underlie these plant effects are not completely elucidated, these results appear to support the potential medicinal use of Croton pullei var. glabrior Lanj. against painful and inflammatory diseases.