Navegando por Assunto "Diabetes mellitus"

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Acesso aberto (Open Access)
Análise do remédio artesanal “tintura de pata-de-vaca” tendo a tintura de Bauhinia monandra Kurz como referência
(Universidade Federal do Pará, 2016-03-17) SILVA, Ana Paula Paiva da; SILVA, Marcos Valério Santos da; http://lattes.cnpq.br/0379783635000306; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
Diabetes mellitus is one of the various pathologies can be controlled with the use of medicinal plants, which exhibit hypoglycemic activity through different mechanisms. In Marudá, Marapanim-PA, the Women's Group "Erva Vida", produces and markets the "Tintura de pata-de-vaca" consumed by tourists and locals to treat diabetes. This remedy is prepared from leaves of Bauhinia monandra Kurz (pata-de-vaca). Different metabolic classes of plant already had a proven hypoglycemic action, for example flavonoids. Thus, the aim of this study was to characterize the handmade medicine through pharmacobotanic parameters pharmacognostic, phytochemicals and chromatographic in compararação with a tincture of Bauhinia monandra, for the presence of flavonoids. Both the preliminary phytochemical analysis, and the analysis by Thin Layer Chromatography, phenolic metabolites detected, possibly flavonoids in handmade medicine and hydroethanolic extract of plant species. In the analysis by HPLC, it revealed the presence of rutin in handmade medicine as well as in hydroethanolic extract of Bauhinia monandra.
Acesso aberto (Open Access)
Concentrações séricas de rifampicina e glicemia em pacientes com tuberculose pulmonar ativa
(Universidade Federal do Pará, 2019-08-30) FONSECA, Adriana Aparecida Durães; VIEIRA, José Luiz Fernandes; http://lattes.cnpq.br/2739079559531098; https://orcid.org/ 0000-0003-4842-8762
Tuberculosis is a chronic disease caused by Mycobacterium tuberculosis, is considered an important public health issue in Brazil with approximately 70 to 90 thousand cases reported each year. The rates of incidences of chronic comorbidities associated with obesity increased in the last years, and, consequently, the coexistence of tuberculosis and diabetes mellitus also increase. There is an interesting interaction between these chronic diseases, as diabetes mellitus alter the immune response to infection and the pharmacokinetics of anti-tuberculosis drugs, and tuberculosis difficult the glycemic control in patients with diabetes. The aim of the study was to investigate the influence of diabetes mellitus on the serum concentrations of rifampicin in a cohort of patients under treatment with anti-tuberculosis drugs. After fasting of 12 hours, the concentrations of rifampicin, blood glucose levels, and glycated hemoglobin levels were measured at 1h after the ingestion of 600 mg of rifampicin. A total of 49 patients were included in the study and allocated in the TB group (n=36) and TB-DM group (n=13). The dose administered of rifampicin was similar in both groups, with median values of 9,82mg/kg and 10,14mg/kg in TB and TB-DM groups. The median serum concentrations of rifampicin in the intensive phase of treatment were 6,83µg/ml e 2,2µg/ml and in the continuation, were 2,75µg/ml and 2,48µg/ml, in TB and TB-DM groups. Approximately 12,25% of study patients presented rifampicin serum levels above the recommended value (8µg/ml). The concentrations of rifampicin were similar in TB and TB-DM groups in both treatment phases, but TB group present significant high levels of the drug in the acute phase of treatment. Moreover, the concentrations of rifampicin did not correlate significantly with glucose levels and glycated hemoglobin levels in both groups. Diabetes Mellitus did not provoke significant changes in serum rifampicin concentrations, but the treatment phase had a significant impact on drug levels.
Acesso aberto (Open Access)
Efeito da suplementação de altas doses de colecalciferol sobre o comportamento da pressão arterial em pacientes normotensos com diabetes mellitus tipo 1
(Universidade Federal do Pará, 2018-12-26) QUEIROZ, Natércia Neves Marques de; FELÍCIO, João Soares; http://lattes.cnpq.br/8482132737976863
Type 1 diabetes mellitus is an endocrine disease highly associated to cardiovascular (CV) risk. Vitamin D (VD) deficiency has been associated to a burden of chronic diseases due to the presence of vitamin D receptors (VDR) through diverse human tissues such as smooth vascular muscle, endothelium, cardiomiocytes and juxtaglomerular cells. Some studies have suggested an inverse relationship between vitamin D levels and blood pressure. High mean blood pressure levels have been found in vitamin D deficient patients. Additionally, previous studies have suggested that the VD-VDR complex might act as a negative regulator factor over renin angiotensin system, which could be responsible for positive effects on blood pressure. The main objective of this study was to evaluate high doses vitamin D supplementation effects on blood pressure of normotensive T1DM patients. Our study was a prospective interventionist study in 35 T1DM patients. The patients with vitamin D lower them 30ng/ml received 10.000UI/daily e if was 30-60 ng/ml was gave 4.000UI/daily. They made 24-hour ambulatory blood pressure monitoring, gycated hemoglobin, creatin, lipids profile, PCRus, before and after 12 weeks. We found an expressing reduce of systolic and diastolic morning blood pressures (117 ± 14 vs 112±14, p<0,05; 74±9 vs 70±10 mmHg, p<0,05, respectively) with no changes in order pressoric markers. Besides, we notice correlation between levels of VD after supplementation and diastolic morning blood pressure (r= -0,4; p<0.05). In conclusion, our study suggest that was an association with supplementation of high doses of vitamin D and reduce of morning blood pressure in normotensives type 1 diabetes mellitus patients.
Acesso aberto (Open Access)
Influência da suplementação de altas doses de vitamina D no controle glicêmico em pacientes com diabetes mellitus tipo 1
(Universidade Federal do Pará, 2018-12-10) MELO, Franciane Trindade Cunha de; FELÍCIO, João Soares; http://lattes.cnpq.br/8482132737976863; YAMADA, Elizabeth Sumi; http://lattes.cnpq.br/7240314827308306
Although the intensive glycemic control of Diabetes Mellitus (DM) with insulin has reduced the incidence of microvascular and macrovascular complications, most patients still develop these injuries with high morbidity and mortality. It has been suggested that low levels of vitamin D (VD) may be associated with the development of Type 1 diabetes mellitus (DM1) and poor glycemic control. As a therapeutic potential, the use of VD in patients with DM1 has presented controversial results regarding the reduction of glucose levels. The objective of this study is to analyze the effects of high-dose vitamin D supplementation on glycemic control of patients with DM1, assessed through glycated hemoglobin levels (HbA1c). A prospective, 12week clinical trial including 52 patients with DM1, which were supplemented with high doses of cholecalciferol, was performed. The dose used for this vitamin was according to the participant's VD value. Patients with VD levels below 30 ng / mL received 10,000 IU / day, and when 30-60 ng / mL, they used 4,000 IU / day. The levels of VD and HbA1c were evaluated before and after 3 months of vitamin supplementation. When we analyzed the total number of patients (N = 52), there was no improvement in the glycemic control evaluated by HbA1c ((9.3 ± 2.3 vs 9.5 ± 2.4, p=NS). To better study the effects of VD on HbA1c, patients were divided into 3 groups according to HbA1c variation: those whose HbA1c reduced ≥ 0.5% (group 1, N = 14); those with no variation in HbA1c (group 2, N = 19) and those with ≥ 0.5% increase in HbA1c (group 3, N = 24). There was a decrease in HbA1c in only one specific group (N = 14). In addition, there was no reduction in prandial basal insulin needs or full dose after three months of VD supplementation. Thus, our data suggest that there is no additional benefit of VD supplementation in the optimization of glycemic control evaluated by HbA1C in patients with DM1.
Acesso aberto (Open Access)
Pacientes portadores de diabetes mellitus tipo2 atendidos no Instituto de Previdência e Assistência do município de Belém IPAMB: aspectos epidemiológicos e genéticos
(Universidade Federal do Pará, 2019-06-18) OLIVEIRA, Bárbara de Alencar; GUERREIRO, João Farias; http://lattes.cnpq.br/1000688763895346
Diabetes mellitus has been considered a 21st century epidemic and each year the number of people with the disease increases worldwide. It is a disease caused by modifiable factors such as hypercaloric diet, sedentary lifestyle, and non-modifiable factors such as genetic heritability. The objective of this study was to describe the occurrence of genetic markers associated with type 2 diabetes mellitus in the population of the city of Belém do Pará, Brazil. The specific objectives were: to validate the association between type 2 diabetes mellitus and the genes: KCNJ11 rs5219, TCF7L2 rs7901695, PPARγ rs1801282, ABCA1 rs9282541, FTO rs8050136 and rs9939609; and investigate the association between factors related to the development and evolution of type 2 diabetes mellitus such as: BMI, waist circumference, systemic arterial hypertension, sedentary lifestyle, smoking, alcoholism and metabolic syndrome. A research form was applied and blood was collected for DNA extraction. A case-control study was conducted with 147 individuals. The sample consisted of 54 women and 49 men, totaling 103 individuals with the disease, and the control group with 27 women and 17 men without type 2 diabetes mellitus, pre-diabetes or any other type of diabetes, totaling 44 individuals. The study was carried out at the Belém Municipal Institute of Welfare and Care. Regarding the genes studied, only KCNJ11 rs5219 was statistically significant in women (n = 81, p = 0.025). Considering the factors associated with type 2 diabetes mellitus, only the metabolic syndrome presented statistical significance in both genders (p = 0.01).
Acesso aberto (Open Access)
O potencial de Luehea divaricata como tratamento fitoterápico tradicional no combate a diabetes mellitus em uma comunidade amazônica
(Universidade Federal do Pará, 2023-12-12) SILVA, Gabrielle de Nazaré Falcão da; OLIVEIRA, Euzébio de; http://lattes.cnpq.br/1807260041420782; https://orcid.org/0000-0001-8059-5902; SILVA, Iracely Rodrigues da; http://lattes.cnpq.br/5393264898435715
This dissertation aims to investigate the use of Luehea divaricata, a medicinal plant with notable phytotherapeutic potential, in the treatment of Diabetes mellitus in the Quilombola Agrovillage of Macapazinho, located in the municipality of Castanhal, in the northeastern region of the state of Pará. The research was conducted through a descriptive qualitative methodological approach, employing techniques such as Respondent Driven Sampling (RDS), interviews, and a scientific review of the active properties of the aforementioned species. The results indicated the anti-diabetic potential of the plant due to the presence of active principles that act in reducing glycemia, offering promising prospects for future scientific investigations in combating diabetes. The validation of its use as a phytotherapeutic medicine will require a systematic application of precision and accuracy tests, in accordance with the guidelines established by the National Health Surveillance Agency (ANVISA).