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Item Acesso aberto (Open Access) Does plasma ANP participate in natriuresis induced by a-MSH?(1997-04) DINIZ, Domingos Luiz Wanderley Picanço; OLIVEIRA, Gustavo Ribeiro de; FAVARETTO, Ana Lucia Vianna; GUTKOWSKA, J.; MCCANN, S.M.; RODRIGUES, José Antunes-Melanocyte-stimulating hormone (-MSH; 0.6 and 3 nmol) microinjected into the anteroventral region of the third ventricle (AV3V) induced a significant increase in diuresis without modifying natriuresis or kaliuresis. Intraperitoneal (ip) injection of -MSH (3 and 9.6 nmol) induced a significant increase in urinary sodium, potassium and water excretion. Intraperitoneal (3 and 4.8 nmol) or iv (3 and 9.6 nmol) administration of -MSH did not induce any significant changes in plasma atrial natriuretic peptide (ANP), suggesting that the natriuresis, kaliuresis and diuresis induced by the systemic action of -MSH can be dissociated from the increase in plasma ANP. These preliminary results suggest that -MSH may be involved in a -MSHindependent mechanism of regulation of hydromineral metabolism.