Navegando por Assunto "Esquizofrenia"

Agora exibindo 1 - 3 de 3

Acesso aberto (Open Access)
Análise de variações genômicas em genes da região cromossômica 22q11.2 em pacientes esquizofrênicos do Estado do Pará
(Universidade Federal do Pará, 2015-08-29) MORAES, Leopoldo Silva de; BURBANO, Rommel Mario Rodriguéz; http://lattes.cnpq.br/4362051219348099
The COMT Val158Met and ZDHHC8 rs175174 polymorphisms have received increased attention in the molecular study of schizophrenia not only because they are localised to the main susceptibility locus of the disease, 22q11, but also because they are related to the dopaminergic status of the prefrontal cortex and the activity of several neuronal proteins, respectively. To evaluate the influence of the polymorphic genotypes on schizophrenia, we used real-time PCR to genotype 130 patients and 175 controls in a population from the North Region of Brazil. Our results indicated an absence of association between both polymorphisms and the likelihood of schizophrenia in the population studied. However, when categorised by gender, we found a dichotomous association between the Met/Met genotype of the COMT Val158Met polymorphism and susceptibility to schizophrenia, conferring a higher probability of disease in men (OR = 10.76; CI 95% = 2.09–55.34; p = 0.004) than in women (OR = 0.23; CI 95% = 0.07–0.69; p =0.009). Moreover, the variance analysis showed an association of the genotypes Val/Met (COMT Val158Met) and GG (ZDHHC8 rs175174) with higher average age at onset of schizophrenia. Our study supports the hypothesis of a gender-dependent association of the COMT Val158Met polymorphism with schizophrenia, in addition to suggesting an influence of both polymorphisms studied on the age at disease onset.
Acesso aberto (Open Access)
Avaliação de microRNAs circulantes na esquizofrenia: da desregulação epigenômica a potenciais biomarcadores
(Universidade Federal do Pará, 2021-03) RODRIGUES, André Luiz de Souza; BURBANO, Rommel Mario Rodriguéz; http://lattes.cnpq.br/4362051219348099; https://orcid.org/0000-0002-4872-234X
Introduction: Schizophrenia is a serious and complex pathology that affects about 0.5-1% of the world's population. For the clinical diagnosis of schizophrenia, there are clinical criteria to be evaluated, which include both positive and negative symptoms. In the origin of the disease, there is a close relationship between environmental stimuli, and strong evidence shows that these stimuli have the ability to act on epigenetic mechanisms, which act in the regulation of gene expression. MicroRNAs (miRNAs) are stable and potentially reliable biomarkers, and some miRNAs have been previously identified as potential biomarkers for schizophrenia in peripheral samples. Objective: To evaluate the expression profile of circulating miRNA's in patients with schizophrenia (hsa-miR-34a, miR-449a, miR-564, miR-432, miR-548d, miR-572 and miR-652) in relation to control individuals negative for the disease. Methods: Analytical, case-control, cross- sectional study using samples previously collected from patients diagnosed with Schizophrenia (N = 650) and control group (N = 924), who adequately met the inclusion criteria. The samples were analyzed after RNA extraction through its quantification and techniques for obtaining reverse transcriptase reaction and real-time quantitative polymerase chain reaction. All data were analyzed using IBM SPSS22 statistical program. Results: Using the peripheral blood collection method with the intention of finding possible biomarkers for schizophrenia, an increased expression of the miRNA’s miR-34a, miR-449a, miR-564, miR-432, miR-548d, miR-572 and miR-652 was observed in several scenarios analyzed, confronting the case and control groups, as well as variables within the case-group, demonstrating potential diagnostic value.
Acesso aberto (Open Access)
Vivências no PIBID: experiência vivenciada com uma aluna com esquizofrenia e deficiência intelectual na Educação de Jovens e Adultos em Bragança
(Executiva Paraense dxs Estudantes de Pedagogia, 2018-07) SILVA, Hanna Rodrigues da; VILA NOVA, Jennifer; SOUZA, Dina