Navegando por Assunto "Etnofarmacologia"

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Acesso aberto (Open Access)
Avaliação da atividade cicatrizante do extrato hidroalcoólico de Ayapana triplinervis (Vahl) R.M. King & H. Robinson (ASTERACEAE)
(Universidade Federal do Pará, 2020-07-16) NASCIMENTO, Suellen Carolina Martins do; LIMA, Anderson Bentes de; http://lattes.cnpq.br/3455183793812931; https://orcid.org/ 0000-0002-0534-2654; ANDRADE, Marcieni Ataíde de; http://lattes.cnpq.br/8514584872100128; https://orcid.org/ 0000-0001-5875-695X
Wound healing is a complex process that involves the organization of cells, chemical signals and remodeling in order to repair injured tissue. North American statistical data show a prevalence of skin lesions in approximately 22.8% of the world's population. In Brazil, wounds are a serious public health problem. In this sense, the use of medicinal plants as therapeutic agents has aroused interest among researchers due to their most different effects, including healing. Thus, ethnopharmacological studies are found in the literature, which associate the use of A. triplinervis with wound healing, but there is no scientific evidence to prove this activity. Thus, this study aims to evaluate the healing potential of the hydroalcoholic extract of A. triplinervis incorporated in an ointment of 5 and 10%. For that, phytochemical analyzes were carried out: prospecting of the plant drug and the hydroalcoholic extract, by means of colorimetric, precipitation tests, thin layer chromatography and high-performance liquid chromatography of the hydroalcoholic extract. In addition to the macroscopic, morphometric analysis, and histological examination of the hydroalcoholic extract ointment in 5% and 10%, using Dersani® and saline solution, respectively, as positive and negative controls. Through these tests, it was observed that the plant drug presented several compounds: saponins, anthraquinones, steroids and triterpenes, polyphenols and coumarins. For the hydroalcoholic extract the result was similar, but the tests did not indicate the presence of anthraquinones. Analysis by thin layer chromatography of the hydroalcoholic extract revealed positive results for coumarins, steroids and triterpenes. In the chromatographic profile, the extract, obtained by high performance liquid chromatography, showed a peak, being suggestive of coumarin. Macroscopic analysis of the lesions showed that the groups of the 5% and 10% extract ointments had more re-epithelialized wounds. In morphometry there was no statistical difference between the four test groups in the percentage of wound contraction. However, the histological examination showed that the ointment with 10% hydroalcoholic extract showed better quality in the development of tissue repair, as it increased fibroblasts, collagen, keratinization, more than the other groups. Thus, this study showed that A. triplinervis extract ointment did not accelerate the speed of wound closure, however, it did show a beneficial influence on the quality in which the lesions evolved, yet further research is necessary to better understand It is made.
Acesso aberto (Open Access)
Avaliação de atividade antimicrobiana e perfil fitoquimíco de plantas medicinais utilizadas por comunidades remanescentes de quilombos no Marajó
(Universidade Federal do Pará, 2020-12-28) SILVA, Suzana Helena Campelo Nogueira da; MONTEIRO, Marta Chagas; http://lattes.cnpq.br/6710783324317390; https://orcid.org/ 0000-0002-3328-5650; SILVA, Consuelo Yumiko Yoshioka e; http://lattes.cnpq.br/8337688339279747; https://orcid.org/ 0000-0002-9120-1910
The ethnopharmacological survey is recognized as one of the most viable methods in the search for new medicinal plants, with the ultimate purpose of producing medicines of natural or semi-synthetic origin. In this sense, the remaining communities of Amazonian quilombolas (Marajó-PA) carry with them a great deal of knowledge about the use of medicinal plants, which has been passed down for generations in Mararajo soil, promoting the value of popular knowledge and its applicability in future studies. The objective of this study is to provide scientific support for the traditional use of plants in the treatment of dermatological diseases in quilombola communities in Marajó that do not yet have an adequate chemical and / or pharmacological study. During the fieldwork carried out between 2017 and 2018, 13 communities were interviewed, in which 7 plants with use in skin diseases were cited. Such plants were collected, and their exsiccates were prepared. After botanical identification by a qualified professional, an extensive bibliographic review was carried out, after which 3 plants were selected for phytochemical and pharmacological study (in vitro in Microsporum and Staphylococcus aureus). In addition, they were subjected to ORAC antioxidant and TP total polyphenols tests. The phytochemical profile was analyzed using liquid chromatography coupled to mass spectrometry (LC-MS) providing 17 chemical constituents, belonging to the flavonoid class. The results of the in vitro tests showed an antibacterial potential of the ethanolic extract of the leaves of C. alatus (MIC) of 0.625 µg / mL and (CBM) of 0.734 µg / mL and of the ethanol extract of the roots D. floribunda (MIC) of 125, 0 ug / mL and 200.0 μg / mL (CBM) compared to S. aureus, with emphasis on the F3 fraction (MIC) 25.0 μg / mL and (CBM) of 132.0 which presented the highest bacterial inhibition. Therefore, the results contributed to the validation of popular use and chemical characterization of the species that presented antimicrobial potential, which can be a promising candidate for herbal medicine.
Acesso aberto (Open Access)
Caracterização química, avaliação da toxicidade oral aguda e da atividade antinociceptiva do extrato metanólico das folhas de Montrichardia linifera (Arruda) Schott
(Universidade Federal do Pará, 2024-08) COSTA, Wellington Junior Taisho Nagahama; AMARANTE, Cristine Bastos do; http://lattes.cnpq.br/4101983776191966; https://orcid.org/0000-0002-8602-8180; BASTOS, Gilmara de Nazareth Tavares; http://lattes.cnpq.br/2487879058181806
Background: Montrichardia linifera (Arruda) Schott is popularly known as “aninga”, “aningaçu”, “aningaíba” and “aninga-do-igapó”. The compresses and plasters from the leaves of the medicinal plant are used to treat abscesses, tumors and pain caused by stingray stings. Aim of the study: The study aimed to investigate the antinociceptive potential of the methanolic extract of Montrichardia linifera leaves (MEMLL), as well as carry out chemical characterization and acute oral toxicity. Materials and methods: The leaves were collected during the rainy season and the methanolic extract was obtained after gradient extraction in different solvents. The MEMLL was analyzed using high performance liquid chromatography (HPLC) and Nuclear Magnetic Resonance (NMR). The evaluation of the acute oral toxicity test was used to observe the presence of toxic substances. Subsequently, acetic acid, hot plate and formalin tests were used to evaluate the analgesic effects. Results: The HPLC fingerprint analysis allowed the identification of rutin, quercetin and epicatechin. The analysis of NMR spectra identified rutin and quercetin, as well as the flavonoids luteolin and chrysoeriol. The MEMLL did not demonstrate effects considered toxic. In the acetic acid test, the MEMLL inhibited peripheral pain by 51.46% (p < 0.05) at a dose of 50 mg/kg and 75.08% (p < 0.001) at a dose of 100 mg/kg. The hot plate test evaluated the latency time of animals, demonstrating central activity at 30 and 60 min increasing by 164.43% (p < 0.01) and 122.95% (p < 0.05) at a dose of 50 mg /kg and 162.62% (p < 0.01) and 136.68% (p < 0.05) at a dose of 100 mg/kg. The formalin test evaluated the central and peripheral antinociceptive effect of the MEMLL. In the neurogenic phase, a reduction of 35.25% (p < 0.05) at a dose of 50 mg/kg and 52.30% (p < 0.01) at a dose of 100 mg/kg. In inflammatory pain, a reduction of 66.39% (p < 0.0001) and 72.15% (p < 0.0001) was observed. Conclusion: The antinociceptive activity supports its ethnopharmacological use. This analgesic effect is probably associated with the identified flavonoids, all of which have antioxidant, anti-inflammatory and antinociceptive properties. Furthermore, the MEMLL was non-toxic.
Acesso aberto (Open Access)
Conhecimento e uso de plantas medicinais nas comunidades de uma unidade de conservação: uma contribuição para a gestão da APA Algodoal-Maiandeua
(Universidade Federal do Pará, 2012-08-24) MONTEIRO, Márcia Joana Souza; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
This work aims at the proposal to contribute for the environmental management of Environmental Protection Area Algodoal-Maiandeua, by cultural record and appreciation of the local knowledge. This consideration is in order to provide systematic information on the uses and knowledge of medicinal plants for inclusion in the management plan and encourage sustainable use of natural resources by emphasizing the importance of recognizing these practices, as well as in official inclusion of medicinal plants for health care the local population and in the same direction for suggesting Policy of Medicinal Plants and Herbal Medicines (PNPMF) in such place. So, data collection focused qualitative methodology, because the quest for knowledge about man and his life was thus adopted a methodology informed by a theory about the very nature of man. Data collection emphasizes the qualitative methodology because the pursuit of knowledge about man and his life to take into account a certain methodology consistent with its nature. Moreover, several methods are adopted, with emphasis on observation and interview, the latter aiming to combine a degree of quantification from observation. As a tool was used semi-structured forms, applied by the Community Health Agents (CHA), activity implemented after training on ethnopharmacy and involving the active participation of communities. Literature searches were also performed in order to obtain the medicinal species already cataloged in previous surveys. The survey was conducted involving the four villages that form the APA Algodoal-Maiandeua (Algodoal, Camboinha, Fortalezinha and Mocooca). The answers lead to the achievement of objectives, providing information on medicinal plants and local knowledge related with them, and offering contributions regarding the management of conservation units for sustainable use.
Acesso aberto (Open Access)
Etnofarmácia na ilha de Cotijuba
(Universidade Federal do Pará, 2010-11-04) MAIA, Fernando Luiz Costa; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
The growing use of herbal and home remedies can take place through technological advances and the obvious growing search for less aggressive therapies. This paper reflects on the safe and effective herbal and home remedies that represent real alternatives to lack of access to so-called synthetic allopathic drugs are not available, and especially the role that compliance with pharmaceutical care to these populations in order to better understand its use as a cultural trait ingrained in their daily lives, beliefs and experiences. Discusses the importance of Etnopharmacy because it allows us to access ancient knowledge about medicinal plants, learning about the relationships that develop between people or social groups with home remedies. And yet, as it provides the necessary correlation between the use of home remedies and their possible intoxications and side effects, the prospect of moving to pharmacovigilance. The survey etnofarmacêutico, with users of SUS on the island of Cotijuba, takes place through semi-structured interviews, to determine the disease profile of territory, from the data collection, selection of ACS, and systematic preparation of interviewers and data analysis. During the survey the users cited about 170 plant species used for a variety of problems. Of these 10 species stands out as being the most cited, according to the relative frequency of alleged use of each species for a given offense (FRAPS). With this enabled it to build a proposed phytotherapeutic memento of the island. The paper finally discusses the consolidation of PNPMF and PNPIC as well as the need to implement the PEPMF, the importance of the Internal Commission of Pharmacy and Phytotherapy and the possibility of preparing a business plan for the island, on degraded or degradation.
Acesso aberto (Open Access)
Papel das plantas medicinais na questão de gênero dentre as mulheres pescadoras-erveiras do espaço Erva Vida Sossego/Marudá/Marapanim
(Universidade Federal do Pará, 2011-06-22) MONTEIRO, Maurícia Melo; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
Work from the perspective of the deployment option of herbal therapy in the Health System in the village of Marudá, Marapanim municipality on the northeast coast of Pará, from experience in ethnopharmacy and ethnomedicine of women's group Herb Life, formed by women that before working with phytotherapeutic products were artisanal fishers, discerned a universe that pervades through the constraints imposed by the gender issue, by persistence, despite the limitations, of if remaining united until achieve autonomy, that whether configured in the production and marketing of medicines produced with medicinal plants, based on popular knowledge ancestrally transmitted by oral tradition and was revitalized by these women. With the endorsement, enthusiasm and cooperation of the herbalists-fishers, the experience of group Herb Life was worked as a case study, using qualitative survey techniques such as participant observation and chatting groups during the field research that lasted for 15 months. It was Traced a bias, that converses with the situation of fisherwoman (artisanal fishing) and the popular knowledge about use medicinal plants as medicine. Theoretical reference sought to pay tribute to the good bibliography the authors of de Amazon on the thematic protagonists, that it was possible observed that gender issue in artisanal fisheries bothers and has being studied by the Academy, therefore, as is clear in reading the work done in the Amazon that the use of medicinal plants is a learning alive and linked to riverside or coastal communities Amazonian. Conclusion of the dissertation went to meet the proposed goal know the experience of herbalists-fishers of the group herb life with medicinal plants by generating sufficient information to compose a phytotherapic mementum, necessary for the inclusion of the medicinal plants as therapy option in the SUS of Marudá and understand the process of emancipation of women herbalists-fishers, coming from the knowledge appropriate about the handling and use of medicinal plants.
Acesso aberto (Open Access)
Sabedoria popular no uso de plantas medicinais pelos moradores do bairro do sossego no distrito de Marudá - PA
(Universidade Federal do Pará, 2015) FLOR, Alessandra Simone Santos de Oliveira; BARBOSA, Wagner Luiz Ramos
In the Amazon medicinal plants are a relevant resource for the treatment of several diseases, given the cultural context, access, reliability and low cost compared to industrial medicine. Inside this context, it is located the Marudá District, in the municipality of Marapanim,160 km far from Belém state of Pará, where it is common to use medicinal plants in order to treat health problems. In this sense, this work investigates the popular phytotherapy practice of herbal medicine practiced by the residents of the“Sossego” neighborhood in the District of Marudá-PA, illustrating the importance of medicinal plants for this human group in cultural, economic and environment context. For such purpose, we used a ethnopharmaceutical survey aiming to offer a prospecting tool of these plants employed as a therapeutic resource for the local population.
Acesso aberto (Open Access)
Uso de plantas medicinais na RESEX Marinha Mestre Lucindo: uma forma de diversificar a atividade extrativista local?
(Universidade Federal do Pará, 2018-06-27) LIMA, Maria Augusta de Jesus; BASTOS, Rodolpho Zahluth; http://lattes.cnpq.br/0697476638482653; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
Extractive Reserves (RESEX) are one of 12 categories of the National System of Conservation Units (NSCU) created in 2000, they belong to the group of Sustainable Use Units and have the basic purpose to protect livelihoods and the associated culture of extractivist communities, and ensure the sustainable use of the unit's natural resources. The Marine RESEX are located in transitional areas between marine and terrestrial environment, where the mangrove ecosystem prevails, the creation of these reserves seeks to protect them from anthropic degradation, stimulating the sustainable use of natural resources, and protecting the local biodiversity. The present work analyzes the use of medicinal plants by users of the Mestre Lucindo Marine Extractivist Reserve, seeking to shape it as an additional local extractive activity in order to provide a complementary source of income for the community. The research was developed as a case study with qualitative and quantitative methodology. The data were collected through semi- structured interviews and Rapid Participatory Diagnosis, carried out during community meetings, with prior consent via an Informed Consent Term and Authorization Term for Testimony and Image Use . The survey included residents from the communities of Boa Esperança, Camará, Guarajubal, Livramento and Sossego (a neighborhood located in the district of Marudanópolis), and with the main members of the unit management, representative of the managing body (ICMBio) of the Reserve (AUREMLUC). The data informed by the participants of the communities were used for their socioeconomic characterization and ethnopharmaceutical profile definition. Seventy-four percent of the participants are female, ranging in age from 18 to 92 years. The mean age of women is 42.6 years and for men 65.4 years. The main income source varies according to the community, and 69% of the respondents receive government aid Bolsa Família. Regarding the use of medicinal plants, the interviewees cited 69 different species, distributed in, at least, 32 botanical families. The use allegation is very wide and the usage form is diverse, including teas, bath and garrafadas. Most interviewees have learned to use medicinal plants with their mothers or grandparents and do not see this as a source of income for the family. Due to the anthropogenic deforestation and mismanagement of resources, several species are becoming scarce or very dispersed. In order to minimize the identified problems, a report was prepared on the main medicinal plants found in the area and also a proposal to restore the medicinal flora in RESEX communities. This document was sent to the managing office, ICMBio.