Navegando por Assunto "Euterpe - uso terapêutico"

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Acesso aberto (Open Access)
Efeito do tratamento combinado com laserterapia e gel de açaí na fase proliferativa de reparo em modelo de lesão por ruptura tendínea total em ratos
(Universidade Federal do Pará, 2023-08-13) MENDES, Aurea Gabriela Rodrigues; MORAES, Suellen Alessandra Soares de; http://lattes.cnpq.br/6278397231382779; BATISTA, Evander de Jesus Oliveira; http://lattes.cnpq.br/2206444845201080
Acai extract has been investigated as a pharmacological strategy due to its anti- inflammatory, antioxidant and antinociceptive effects. Furthermore, studies report that low-intensity laser (LBT) may favor tissue repair due to its proliferative effects in increasing the number of fibroblasts and collagen synthesis. Therefore, the combined use of açaí with LBT may be a therapeutic alternative in the management of tendon repair. The aim of this study was to evaluate the effects of combined treatment with açaí gel and LBT on the morphofunctional and nociceptive aspects of Achilles tendon injury in the proliferative phase of repair. For this, 40 Wistar rats were divided into control group (CTRL), injury (INJURY), 10% açaí gel (INJURY+GA), 2J infrared laser, (INJURY+LAS) and combined treatment (INJURY+LAS+GA). The Von Frey test, Joint Angle and Achilles Functional Index were performed at 0-, 3-, 7- , and 14-days post-injury (DPL). After 14 days, the tendons were collected and the tissue organization pattern was analyzed by H&E or Alcian Blue to assess variations in glycosaminoglycans in the extracellular matrix, staining with DAPI to quantify the number of cells and collagen autofluorescence to assess the orientation pattern of collagen fibers. We demonstrated improvement in the macroscopic characteristics of the tendon in the treatment groups in relation to INJURY, which may be correlated with better organization and tissue orientation, as well as collagen fibers in these groups. The increase in the number of cells and fibroblasts was more evident in the laser group, emphasizing the proliferative role of the laser. Functional recovery was observed in 7 DPL in the isolated laser group, while the combined treatment improved nociception in the acute phase (7th DPL). In the proliferative phase (14th DPL), the IFA showed improvement in functional aspects in the combined treatment group. On the other hand, nociceptive sensitivity was reestablished in all treatment groups. In summary, our findings indicate that the combined use of açaí gel with LBT may be a therapeutic alternative in the management of tendon injury repair.
Acesso aberto (Open Access)
O uso de compostos fenólicos na prevenção da doença de parkinson: análise bibliométrica e crítica dos 100 artigos mais citados da Web of Science e avaliação neuroprotetora do açaí (euterpe oleracea) em ratos wistar
(Universidade Federal do Pará, 2022-12) SANTOS JUNIOR, José Messias dos; LIMA, Rafael Rodrigues; http://lattes.cnpq.br/3512648574555468; HTTPS://ORCID.ORG/0000-0003-1486-4013; ROGEZ, Hervé Louis Ghislain; http://lattes.cnpq.br/5202118426597590; https://orcid.org/0000-0001-8925-8881
Parkinson's disease is characterized by the death of dopaminergic neurons with both motor and non-motor symptoms. The current treatment available does not prevent the progression of the disease and, therefore, new alternatives have been sought for its prevention. Phenolic compounds that are present in foods and beverages of plant origin have bioactivities including antioxidant and anti-inflammatory activity that may contribute to neuroprotection. The general objective of this thesis is to evaluate bibliometric parameters and experimental designs of the 100 most cited articles from WoS-CC on the use of phenolic compounds in Parkinson's disease and to carry out an in vivo laboratory study using Wistar rats exposed to açaí for 15 days before induction of Parkinson's disease-like symptoms through 6-hydroxydopamine. The 100 most cited articles in WoS-CC are predominantly from the Asian continent and China, EGCG and oxidative stress being the most evaluated compound and therapeutic target among the 100 studies. In vitro and in vivo laboratory studies represent approximately 70% of the list. The results demonstrated among the 100 articles are due to concentrations and administration routes that do not resemble consumption through the diet. Pre-treatment with açaí increased GSH levels and decreased MDA levels, in addition to preventing damage to spontaneous locomotion. The results suggest the neuroprotective potential of açaí related to its composition of phenolic compounds.