Navegando por Assunto "Glicemia"

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Acesso aberto (Open Access)
Associação do índice de massa corporal com a glicemia de jejum e pressão arterial em indígenas
(Universidade Federal do Pará, 2008-02-13) REIS, Rosilene Costa; GUERREIRO, João Farias; http://lattes.cnpq.br/1000688763895346
This study aims to measure and describe the shape of the relationship between BMI, fasting plasma glucose and blood pressure on indigenous groups of Amazonia Para. We studied 297 adults across the ethnic Kaip (Xikrin and Kararaô), Araweté, Parakanã, and Arara Asurini located in the State of Pará, northern Brazil. The variables BMI, blood glucose and blood pressure were measured and categorized as still in overweight, obesity, diabetes, the glucose intolerance and hypertension. The relationship of BMI with the other variables was tested by linear regression method by adopting a significance level of 5% (p ≤ 0.05). Mean BMI (23.7 kg/m2), fasting plasma glucose (83.4 mg / dL), diastolic blood pressure (60.0 mmHg) and age (49 years) showed no significant difference between genders and for men only systolic blood pressure (98.0 mmHg) was higher. The prevalence of overweight was 23.6% and obesity from 5.7%. Were not identified new cases of diabetes mellitus type 2, but four cases (1.3%) of the disease were reported. The impaired glucose tolerance was present in 2.4% of the population and hypertension in 1.3%. The BMI associated with the glucose, systolic blood pressure and diastolic blood pressure (DBP), is better explained from diastolic blood pressure (BMI = 20590 +0.52 DBP). The relationship of BMI with blood glucose levels and blood pressure was positive, but further studies are needed to have more clarity between cause and effect.
Acesso aberto (Open Access)
Concentrações séricas de rifampicina e glicemia em pacientes com tuberculose pulmonar ativa
(Universidade Federal do Pará, 2019-08-30) FONSECA, Adriana Aparecida Durães; VIEIRA, José Luiz Fernandes; http://lattes.cnpq.br/2739079559531098; https://orcid.org/ 0000-0003-4842-8762
Tuberculosis is a chronic disease caused by Mycobacterium tuberculosis, is considered an important public health issue in Brazil with approximately 70 to 90 thousand cases reported each year. The rates of incidences of chronic comorbidities associated with obesity increased in the last years, and, consequently, the coexistence of tuberculosis and diabetes mellitus also increase. There is an interesting interaction between these chronic diseases, as diabetes mellitus alter the immune response to infection and the pharmacokinetics of anti-tuberculosis drugs, and tuberculosis difficult the glycemic control in patients with diabetes. The aim of the study was to investigate the influence of diabetes mellitus on the serum concentrations of rifampicin in a cohort of patients under treatment with anti-tuberculosis drugs. After fasting of 12 hours, the concentrations of rifampicin, blood glucose levels, and glycated hemoglobin levels were measured at 1h after the ingestion of 600 mg of rifampicin. A total of 49 patients were included in the study and allocated in the TB group (n=36) and TB-DM group (n=13). The dose administered of rifampicin was similar in both groups, with median values of 9,82mg/kg and 10,14mg/kg in TB and TB-DM groups. The median serum concentrations of rifampicin in the intensive phase of treatment were 6,83µg/ml e 2,2µg/ml and in the continuation, were 2,75µg/ml and 2,48µg/ml, in TB and TB-DM groups. Approximately 12,25% of study patients presented rifampicin serum levels above the recommended value (8µg/ml). The concentrations of rifampicin were similar in TB and TB-DM groups in both treatment phases, but TB group present significant high levels of the drug in the acute phase of treatment. Moreover, the concentrations of rifampicin did not correlate significantly with glucose levels and glycated hemoglobin levels in both groups. Diabetes Mellitus did not provoke significant changes in serum rifampicin concentrations, but the treatment phase had a significant impact on drug levels.
Acesso aberto (Open Access)
Diagnóstico das deficiências de macro e micro minerais em búfalas (Bubalus bubalis) provenientes da Ilha de Marajó, Estado do Pará
(Universidade Federal do Pará, 2014-06-30) OLIVEIRA, Carlos Magno Chaves; BARBOSA NETO, José Diomedes; http://lattes.cnpq.br/1516707357889557
This study aimed to evaluate in buffaloes of the Marajó Island serum concentrations and phosphorus in bones, the percentage of ashes and the specific density of the bones, the levels of copper, cobalt, selenium, zinc and iron before and after selective mineral supplementation. For this study, 14 crossbred buffaloes of Murrah and Mediterranean aged between 18 and 36 months were used. The average values of phosphorus, before supplementation, were 5, 68 mg/dl ± 1.18 in serum and 16.53% ± 0.53 in the bones. The percentage of ashes in bones was 59.95% ± 1.96 and the specific bone density was 1,52 g/cm3 ± 0.32, which demonstrates a phosphorus deficiency in animals raised on the island of Marajó. The average copper values were 7.75 ± 1.73 ppm, the cobalt ± 0.17 0.40 ppm, the zinc of 88.01 ± 35.03 ppm, the 0.22 ppm selenium and iron ± 0.12 1395.72 ± 764.74 ppm. These results indicate a deficiency of copper, zinc and selenium, cobalt and appropriate values of excess iron in the liver. After supplementation for a period of seven months the phosphorus values were 6.61 mg / dl in serum ± 0.87 and 16.90 ± 0.56% in the bones. The percentage of ash was 60.30% ± 0.95 and the specific bone density was 1.71 g/cm3 ± 0.21. These values characterize a significant increase in the concentrations of P in blood serum, in the percentage of P in the ashes and on specific bone density (P < 0.05), however there wasn't a significant increase in the percentage of ash. The average increase in the values of P in the bones and the ashes did not reach heights of normality, however 28.6% of the animals had normal serum P values, 50% had normal values of P in the ashes and 64.3% of the animals had specific normal bone density. There was no response to supplementation in relation to the percentage of ash. Regarding micro minerals, after supplementation values were 205.41 ± 80.54 ppm for copper, 0.40 ± 0.22 ppm for cobalt, 75.71 ± 11.74 ppm for zinc, 1.30 ppm ± 1.34 for selenium and 826.48 ± 394.76 ppm for iron, which shows a significant increase (P <0.05) concentrations of copper and selenium and a significant decrease in the amounts of iron (P <0, 05). There was no response to supplementation in relation to the percentage of ashes. Regarding micro minerals, after supplementation values were 205.41 ± 80.54 ppm for copper, 0.40 ± 0.22 ppm for cobalt, 75.71 ± 11.74 ppm for zinc, 1.30 ppm ± 1.34 for selenium and 826.48 ± 394.76 ppm for iron, which shows a significant increase (P <0.05) concentrations of copper and selenium and a significant decrease in the amounts of iron (P <0, 05). There was no recovery of zinc and cobalt concentrations which remained within the normal range. Failure to increased concentrations of zinc in the liver after supplementation may have occurred because of the high concentrations of calcium in Brachiaria brizantha cv Marandu used in animal nutrition.
Acesso aberto (Open Access)
Influência da suplementação de vitamina D na variabilidade glicêmica em pacientes com diabetes Mellitus tipo 1
(Universidade Federal do Pará, 2016-01-27) FELÍCIO, Karem Mileo; YAMADA, Elizabeth Sumi; http://lattes.cnpq.br/7240314827308306; FELÍCIO, João Soares; http://lattes.cnpq.br/8482132737976863
Recent studies suggest that glycemic variability (GV) could influence the risk of complications in diabetes, independently from glycemic control (GC). GV is the evaluation of the daily fluctuations of glycemia through specific calculations. The few studies that have assessed the effects of supplementation with vitamin D (VD) in patients with diabetes type 1(DM1) on GC are controversial and there is no data about a possible action of VD on GV in these patients. Our study aims to evaluate the effects of VD supplementation on GV in patients with DM1. We executed a prospective, controlled study with 22 patients with DM1. Doses of either 4.000 or 10.000 IU/day of cholecalciferol were administered for 12 weeks according to the patient’s previous vitamin D serum levels. All patients were submitted to continuous glucose monitoring system (CGMS) with the analysis of 41.000 glycemias, dosage of vitamin D and HbA1c before and after the treatment. When the pre and post treatment variables were compared, no differences were observed, except for the expected improvement of the levels and status of VD (26,1 ± 9,0 vs 44,4 ± 24,7 ng/mL ; p<0,01 e 1,00 ± 0,76 vs 0,36 ± 0,66 ; p<0,01), respectively. Correlations were found between the percentage variation (Δ) of the glycemia standard deviation (ΔGSD), calculated using the CGMS, with Δ of the basal (r= 0,6; p<0,01) and total insulin (r= 0,6; p<0,01). Our study also found a correlation between the VD status after supplementation and Δ of the prandial (r= 0,5; p<0,05) and total insulin (r= 0,4; p<0,05), indicating that the better the vitamin D status, lower the doses of insulin needed by the patients. To efficiently study the GV, patients were divided in two groups: Patients in which the ΔGSD improved (group 1; N= 12 (55%)) and those in which the ΔGSD worsened (group 2; N= 10 (45%)). Group 1 when compared to group 2 showed lower needs of insulin (Δbasal insulin = -8,0 vs 6,3%; (p<0,05)) and lower frequency of hypoglycemia (12/44 (27%) vs 21/33 (64%), hypoglycemias / days evaluated ; p<0,01). Our data suggests that supplementation of VD on patients with DM1 could improve the GV associated to a lower need of insulin in more than 50% of these patients. The improvement of GV was strongly associated with reduction in frequency of hypoglycaemia. However, it was not possible to demonstrate benefits of vitamin D on glycaemic control measured by the HbA1c.
Acesso aberto (Open Access)
Parâmetros sangüíneos e urinários, no pré e pós parto, de búfalas criadas em sistema exclusivo de pastejo
(2003-06) OLIVEIRA, Carlos Magno Chaves; BARBOSA NETO, José Diomedes; BARBOSA, Imke Barbara Pfeifer; CARDOSO, Deugles Pinheiro
Eight lactating buffaloes of the Murrah breed were used from 60 days before up to 60 days after calving, in order to evaluate alterations in the concentration of blood glucose, total plasmatic protein, haematocrit and the presence of ketonic bodies in the urine. The 5 to 10- year old buffaloes were clinically healthy and had had at least two lactations. During the experimental period the animals were maintained on Brachiaria brizantha pasture and supplemented with a mineral mixture and water.The media concentrations of blood glucose and the media values of the haematocrit diminished significantly after calving (p<0,05). The concentrations of total plasmatic protein did not show significant variation during the pre and post-calving period. The ketonic bodies in the pre-calving period were only detected in the urine of one buffaloe, but after the 32nd day of lactation ketonic bodies were detected in all animals. There was a direct relationship between the color of the urine positive by the Rothera test and blood glucose concentrations. It can be concluded that at the beginning of lactation the buffaloes had an energetic deficit, characterized by a decline of blood glucose concentrations and the presence of ketonic bodies in the urine, and that lactation caused a progressive decline of the hematocrit, but that the concentration of total plasmatic protein did not vary during the pre and post-calving period.