Navegando por Assunto "Hepatite"

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Acesso aberto (Open Access)
Effect of copaiba oil in hepatic damage induced by acetaminophen in rats
(Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2013-07) TEIXEIRA, Renan Kleber Costa; YAMAKI, Vitor Nagai; YASOJIMA, Edson Yuzur; BRITO, Marcus Vinicius Henriques
PURPOSE: To investigate the effects of copaiba oil on the hepatic damage induced by paracetamol. METHODS: Thirty six rats were distributed into six study groups (N=6): control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copaiba Group 1, that received copaiba oil two hours before the acetaminophen; Prophylactic Copaiba Group 7, that received copaiba oil seven days, once by day, before the acetaminophen; Therapy Copaiba Group, that received the copaiba oil two hours afther the acetaminophen; and N-Acetyl-Cysteine Group, , that received the N-Acetyl-Cysteine two hours afther the acetaminophen. Euthanasia was performed after 24 hours. The serum levels of AST, ALT, alkaline phosphatase, GT, total bilirubin, direct bilirubin and indirect bilirubin and histological analisis were analized. RESULTS: The prophylactic copaiba group 7, therapy copaiba group and N-Acetyl-Cysteine Group showed amounts of AST and ALT similar to the control group; and the prophylactic copaiba group 1 showed similar levels to the acetaminophen group. There was no significant difference between the groups regarding the amount of alkaline phosphatase and GT (p>0.05). The therapy copaiba group showed the highest levels of bilirubin and was statistically different from the other groups (p<0.01) and this increased the costs of direct bilirubin. Regarding histopathology, the oil of copaiba administered prophylactic or therapeutic form for 7 days could decrease the amount of necrosis and inflammatory infiltrate. CONCLUSION: Copaiba oil administered prophylactically for seven days, and therapeutic could reduce liver damage caused by paracetamol similarly N-Acetyl-Cysteine, however, when treated with copaiba therapeutically showed increases in bilirubin, costs increasing fraction indirect.
Acesso aberto (Open Access)
Hepatitis B and C virus infection among Brazilian Amazon riparians
(2011-10) OLIVEIRA, Claudia Suellen Ferro de; SILVA, Adenielson Vilar e; SANTOS, Kemper Nunes dos; FECURY, Amanda Alves; ALMEIDA, Marcella Kelly Costa de; FERNANDES, Adriana Prado; COSTA, Carlos Araújo da; FREITAS, Andrei Silva; CORVELO, Tereza Cristina de Oliveira; MARTINS, Luisa Caricio
INTRODUCTION: Viral hepatitis is a major public health concern in Brazil. There are few past studies on this issue, especially among riparian communities. This study aims at determining the seroprevalence of viral hepatitis B and C in the riparian community of Pacuí Island, within the Cametá municipality of Pará State, Brazil. Moreover, this study aims to investigate the principal risk factors that this community is exposed to. METHODS: The current study has accessed blood samples from 181 volunteers who have answered an epidemiological questionnaire. Analyses on serological markers have been tested with commercial ELISA kits for detecting HBsAg, total anti-HBc, anti-HBs, and anti-HCV. Within seroreactive patients for HCV, RT-PCR and line probe assay have been performed to identify the viral genotype. RESULTS: In the serological marker analysis for hepatitis B, no reactivity for HBsAg, rate of 1.1% for total anti-HBc, and rate of 19.3% for anti-HBs have been observed. On hepatitis C, 8.8% seroprevalence has been found, in which 62.5% have gotten viral RNA. Among the risk factors studied, the following have been highlighted: non-use of condoms, sharing of cutting instruments, use of illicit drugs, and reports of family disease with HBV or HCV. CONCLUSIONS: The vaccination coverage against HBV is low, and the high prevalence of HCV within this community has been observed.
Acesso aberto (Open Access)
Infecção pelo HCV em uma unidade de diálise em Belém-Pará: desempenho de testes imunoenzimáticos em relação à técnica de biologia molecular
(Universidade Federal do Pará, 1998) CARTÁGENES, Paulo Roberto Brito; ISHAK, Ricardo; http://lattes.cnpq.br/5621101706909450; ARAÚJO, Ronaldo
The main objective of this study was to make a comparative evaluation of four 3rd generation enzyme-linked immunosorbent assay (ELISA) kits (Ortho, Ubi, BioChem and Abbott), for the detection of HCV antibody and Roche polymerase chain reaction (PCR) kit. Serum samples were obtained from 19 members of the staff (grupo A) and 66 patients (grupo B), who were undergoing either hemodialysis (n=54) or peritoneal dialisys (n=12) in a dialysis unit in Belém, Pará. Altogether, the four ELISA kits agreed in 89,5% and 81,8% when results of groups A and B were compared, respectively. Overall rates of HCV antibody ranged from 34,1% to 37,5%. These rates among the patients ranged from 42,4% to 47%. While HCV-RNA was detected by PCR in 25 (37,9%) of the patients (of whom 24 in the hemodialysis subgroup), no PCR-positive results could be yielded among the staff members. When compared with the PCR, the four ELISA kits showed sensitivity, specificity and predictive values with differences that were not statistically significant. Of interest, serum samples from 12,5% to 20% of HCV-infected patients – as diagnosed by PCR – yielded negative results when tested by the four ELISA kits. An additional finding was that increase in the aminotransferasis levels does not seem occur as a result of HCV infection, it is notable that the risk of HCV infection increases following hemodialysis procedure during six months or more, among those patients who are older than fifty years. In addition, among patients subjected to hemodialysis, a high rate (13%) of HBV carriers was found.
Acesso aberto (Open Access)
Infecções pelos vírus das hepatites B e C e o carcinoma hepatocelular na Amazônia oriental
(2004) MIRANDA, Esther Castello Branco Mello; MÓIA, Lizomar de Jesus Maués Pereira; AMARAL, Ivanete do Socorro Abraçado; BARBOSA, Maria Silvia de Brito; CONDE, Simone Regina Souza da Silva; ARAÚJO, Marialva Tereza Ferreira de; CRUZ, Ermelinda do Rosário Moutinho da; DEMACHKI, Samia; BENSABATH, Gilberta; SOARES, Manoel do Carmo Pereira
In order to contribute to a better understanding of the possible role of hepatits B and C in the etiopathogenis of HCC in the East Amazon, there were studied 36 patients in Belém/PA. Serological hepatitis markers were evaluated and polymerase chain reaction assays were used to detect HBV-DNA and HCV-RNA. Alcohol abuse was observed in 33.3% and cirrhosis in 83.3%. In 88.9% of the sample, one or more hepatitis B markers were positive. Also, 8.3% those patients had anti-HCV simultaneously positive. The HBsAg serological test was positive in 58.3%; anti-HBc in 86%; anti-HBe in 85.7%; anti-HBe in 9.5%; IgM anti-HBc in 57.1%. The HBV DNA was found in 37.7% and in 65% of the HBsAg positive. The HCV RNA was detected in 8.5% and in 100% of' the patients positive to anti-HCV. The AFP was above the normal value in 88.9% of patients, with levels up to 400ng/ml in 75% of them. In conclusion, hepatitis B virus infection seems to be important in the etiology of HCC and improving measures such immunization and screening in the risk population should be emphasyzed.
Acesso aberto (Open Access)
Programa de hepatopatias do Hospital da Fundação Santa Casa de Misericórdia do Pará: infra-estrutura e epidemiologia clínica em 10 anos de atendimento
(2004) MÓIA, Lizomar de Jesus Maués Pereira; AMARAL, Ivanete do Socorro Abraçado; CONDE, Simone Regina Souza da Silva; BARBOSA, Maria Silvia de Brito; MIRANDA, Esther Castello Branco Mello; MACEDO, Zilvana Pinheiro de; ARAÚJO, Marialva Tereza Ferreira de; DEMACHKI, Samia; SOARES, Manoel do Carmo Pereira
The Liver Diseases Program of the Hospital Santa Casa de Misericordia do Pará was create because of the need to attend patients with liver diseases of the Amazônia area, taking as priority to attend with quality, diagnosis of aetiologies, clinical following and specific treatment. This study aim to describe dates related to epidemiology, aetiologics agents and histopathologic analisys. One thousand sixthy nine patients were evaluated through medical, laboratory, endoscopic, ultrasound or computadorized tomography and histopathologic examination. Nine hundred thirty five (63,6%) patients within 1469 patients were diagnose as chronic liver disease. The average age was 50 year, 666 (71,2%) were male, and the most patients lived in Belem, state of Pará. The aetiologic agents most prevail were alcoholism (53,7%) and viral hepatitis (39,1%). Hepatic biopsy were done in 403 (43,1%) within the 935 patients and the results showed chronic hepatitis (34%) and chirrosis (34%). In sumary the chronic liver disease in the amazon region is more prevail in male than female, the alcoholism is the principal aetiologie, and the most of these cases were diagnose in the severe phase.