Navegando por Assunto "Leishmania naiffi"
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Item Acesso aberto (Open Access) Avaliação da susceptibilidade de camundongos BALB/c e Swiss, hamster e Proechimys roberti à infecção por Leishmania (Viannia) Naiffi e Leishmania (Viannia) Lindenbergi(Universidade Federal do Pará, 2005) SODRÉ, Roberta Nice Salgado; ISHIKAWA, Edna Aoba Yassui; http://lattes.cnpq.br/3074963539505872Leishmania (Viannia) naiffi and Leishmania (Viannia) lindenbergi are species that cause cutaneous leishmaniasis in Amazonia and present great similarity in its isoenzymatic profile, monoclonals antibodies and production of unapparent infection in hamsters. The fact of not having a highly susceptible experimental model to the infection for L. (V.) naiffi and L. (V.) lindenbergi, the objective of this study was evaluate the susceptibility of BALB/c and Swiss mice, hamsters and Proechimys roberti to the infection for those two species. It was prepared inoculums with salivary glands and without glands for each group of animals, associated to the promastigotes. The experimental animals, of both sexes, were inoculated intradermally in the dorsal surface of back feet and they were observed for 90 days. In the period of 30, 60 and 90 days after inoculation, the animals were sacrificed and different fragments of skin of the inoculation place were used in the culture, microscopic exam and polymerase chain reaction (PCR). It was not possible to observe lesions in the animals inoculated with L. (V.) naiffi and L. (V.) lindenbergi even at the presence or absence of salivary glands. As well as, forms amastigotes during 30, 60 and 90 days after the inoculation. In the culture, all the animals inoculated with L. (V.) lindenbergi haven’t developed promastigotes. For the other hand, BALB/c mice inoculated with L. (V.) naiffi presented positively when sacrificed 30 days after inoculation. PCR presented low sensibility compared to the culture. This way, we concluded that L. (V.) naiffi and L. (V.) lindenbergi is species that present low infectivity and none of the animals used in the study experimental model can be considered highly susceptible to the infection for those two species.