Navegando por Assunto "Memória espacial"

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Acesso aberto (Open Access)
Avaliação da influência do tratamento com indometacina no aprendizado e na memória espacial em modelo murino de diabetes tipo 1
(Universidade Federal do Pará, 2017-05-25) SANTOS, Gabriel Cardoso de Queiroz; BASTOS, Gilmara de Nazareth Tavares; http://lattes.cnpq.br/2487879058181806
Diabetes mellitus (DM) is the group of metabolic disorders that has as a common characteristic the disregulation of blood glucose levels, invariably leading to hyperglycemia. This disease has become the most frequent in the adult population, mainly in developing countries, causing several serious consequences such as cardiovascular and renal diseases, factors responsible for a high mortality rate of the individuals affected. In addition that consequences, which are better investigated and described in the literature, other types of complications are observed. Clinical and experimental studies demonstrate that both type 1 and type 2 diabetes mellitus may contribute to the development of cognitive deficits and dementias. However, the mechanisms that lead to such disorders are not yet fully understood. A study using the non-selective non-steroidal anti-inflammatory, indomethacin, has shown that aspects related to impaired neuronal plasticity in diabetes can be reversed, demonstrating that these disorders may be modulated by neuroinflammatory changes. The aim of the present study was to evaluate the influence of chronic treatment with indomethacin on memory and learning in a murine model of type 1 diabetes mellitus (T1DM). Using the open field test, Y-maze test and Morris water maze test we investigated the indomethacin effects on behaviors changes after aloxan inducing T1DM. Indomethacin significantly decrease related behaviors to the anxious state in Open field test. This treatment also reversed space work memory deficits in the Y-maze test, and learning and spatial memory deficits in the Morris Water Maze. Thus, it can be concluded that chronic treatment with indomethacin has beneficial effects on the cognition of mice submitted to type 1 diabetes mellitus.
Acesso aberto (Open Access)
Influência da atividade mastigatória e do ambiente sobre o aprendizado espacial e o padrão da atividade exploratória em modelo murinho senil
(Universidade Federal do Pará, 2014-04-01) MENDES, Fabíola de Carvalho Chaves de Siqueira; DINIZ, Cristovam Wanderley Picanço; http://lattes.cnpq.br/2014918752636286; SÓSTHENES, Márcia Consentino Kronka; http://lattes.cnpq.br/7881527576747420
To measure possible influences of the mastication and sedentary lifestyle, we imposed masticatory patterns with three different experimental diet regimes starting at 21st postnatal day during 6 (6M) or 18 (18M) months: continuous pellet hard diet, equal periods of hard followed by soft diet or equal periods of hard followed by soft followed by hard diet. To mimic the sedentary and active lifestyles, the animals were raised, respectively in standard (AP) or enriched cages (AE). To measure the effects of diet, environment and age on the exploratory activity, we performed the open field test. Young mice (AP) with altered masticatory activity demonstrated more preference for peripheric zone, but in aging and AE animals these differences were minimized. In the aging specimens maintained in AE, these differences were reappeared. About influences on learning and spatial memory, we apply the Morris water maze and the reduced masticatory activity, regardless of the environment, decreased the average rate of spatial learning and rehabilitation recovered the losses associated in young animals and the association with AE improved the learning rate in old mice. No significant correlations were observed between swimming speed and learning rate. We conclude that the change in masticatory activity influences the pattern of exploration by zones in the open field and environmental stimulation enhances the effects of aging, emphasizing the preference for peripheric zone and reduced masticatory activity impairs spatial memory during the test of the Morris water maze and rehabilitation is able to recover spatial ability. Here, the combination with AE is required in aging.